AiPD: Autoinhibited Protein Database

Gene name	Nat10
Protein name	RNA cytidine acetyltransferase
Names	18S rRNA cytosine acetyltransferase, N-acetyltransferase 10
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:98956
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

39-110 (Predicted disordered autoinhibitory region) PR

39-110 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8K224-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388570881	4	K>N	No	EVA
rs3388575079	7	D>G	No	EVA
rs3388562935	45	S>P	No	EVA
rs3388577812	77	Q>*	No	EVA
rs3388576814	91	D>E	No	EVA
rs3388568341	95	L>P	No	EVA
rs3388569422	107	Y>C	No	EVA
rs3388575064	120	M>I	No	EVA
rs3388575065	136	R>S	No	EVA
rs3388568329	158	K>N	No	EVA
rs3388573012	161	Y>C	No	EVA
rs3388572560	164	T>S	No	EVA
rs3388577827	290	K>N	No	EVA
rs3388575268	364	H>Y	No	EVA
rs3388571238	375	D>G	No	EVA
rs3388575319	423	L>V	No	EVA
rs3391838795	435	S>C	No	EVA
rs3391931558	435	S>W	No	EVA
rs3391978788	437	Q>L	No	EVA
rs3391978213	439	Q>L	No	EVA
rs3388572566	447	K>M	No	EVA
rs259849008	483	D>G	No	EVA
rs235032797	496	V>L	No	EVA
rs3388573075	603	D>N	No	EVA
rs3388570860	607	W>C	No	EVA
rs3388576084	641	G>D	No	EVA
rs3391978133	678	V>D	No	EVA
rs3392003182	684	V>A	No	EVA
rs3391849000	688	R>W	No	EVA
rs3391978803	708	Y>C	No	EVA
rs3391978232	713	Y>H	No	EVA
rs3391902151	714	G>R	No	EVA
rs262035785	718	R>K	No	EVA
rs3391848981	719	L>F	No	EVA
rs248745056	754	D>N	No	EVA
rs3388575298	763	W>C	No	EVA
rs250358437	772	R>Q	No	EVA
rs3388573040	855	G>*	No	EVA
rs3391838794	874	H>Q	No	EVA
rs3391982161	877	V>E	No	EVA
rs245810496	919	V>A	No	EVA
rs3392041730	963	Y>S	No	EVA
rs3391704858	972	W>G	No	EVA
rs3388568338	975	V>A	No	EVA
rs3388572548	1007	K>N	No	EVA
rs3388573098	1015	R>G	No	EVA

Type	Name	Position	InterPro Accession
domain	GNAT domain	528 - 753	IPR000182
domain	Helicase domain	282 - 488	IPR007807
domain	tRNA(Met) cytidine acetyltransferase TmcA, N-terminal	9 - 201	IPR013562
domain	Possible tRNA binding domain	763 - 975	IPR027992

		Description
EC Number
Subcellular Localization	Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
telomerase holoenzyme complex	Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA polymerase binding	Binding to a DNA polymerase.
mRNA N-acetyltransferase activity	Catalysis of the reaction: a cytidine in mRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in mRNA + CoA + H(+) + phosphate.
N-acetyltransferase activity	Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
rRNA cytidine N-acetyltransferase activity	Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.
tRNA binding	Binding to a transfer RNA.

Name	Definition
negative regulation of telomere maintenance via telomerase	Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
protein acetylation	The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic
regulation of centrosome duplication	Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
rRNA acetylation involved in maturation of SSU-rRNA	Any rRNA acetylation that is involved in maturation of SSU-rRNA.
tRNA acetylation	The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53914	KRE33	RNA cytidine acetyltransferase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9H0A0	NAT10	RNA cytidine acetyltransferase	Homo sapiens (Human)	PR
O01757	nath-10	RNA cytidine acetyltransferase	Caenorhabditis elegans	PR
Q9XIK4	At1g10490	RNA cytidine acetyltransferase 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M2Q4	At3g57940	RNA cytidine acetyltransferase 2	Arabidopsis thaliana (Mouse-ear cress)	PR