Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9WV70
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WV70-F1 | Predicted | AlphaFoldDB |
No variants for Q9WV70
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9WV70 | |||||
No associated diseases with Q9WV70
Functions
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Noc1p-Noc2p complex | A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis. |
| Noc2p-Noc3p complex | A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| nucleosome binding | Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| p53 binding | Binding to one of the p53 family of proteins. |
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| cellular response to UV | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. |
| negative regulation of B cell apoptotic process | Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process. |
| negative regulation of histone acetylation | Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein. |
| negative regulation of intrinsic apoptotic signaling pathway | Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39744 | NOC2 | Nucleolar complex protein 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SYU1 | NOC2L | Nucleolar complex protein 2 homolog | Bos taurus (Bovine) | PR |
| Q9VIF0 | CG9246 | Nucleolar complex protein 2 homolog | Drosophila melanogaster (Fruit fly) | PR |
| Q9Y3T9 | NOC2L | Nucleolar complex protein 2 homolog | Homo sapiens (Human) | PR |
| O17580 | pro-2 | Nucleolar complex protein 2 homolog | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASRAPRRR | LEDLSVDEFL | ASGFESGSES | ELEGAAEERR | ARGAAWNRER | RGARTSPGPA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRLRKGRASE | HKDQLSRLKD | RDPEFYKFLQ | ENDRSLLDFS | DSDSSAEEEE | PFHSLPDTLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EASETEEDGG | EDSDALPRGL | RSKKNEPVPV | TLAMVERWRQ | GSRHHLTPRL | FHEVVQAFRA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVATTQGEQE | AAETCRFQVA | DSAVFNALVT | FCIRDLCGCL | QKLLFGKTPK | DSNRLLLPSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SPLWGKLRVD | VKSYLSAVVQ | LAACLAEATV | SAAVLQHISS | LVPYFLTFPK | QCRMLLKRMV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VLWSTGEESL | RVLAFLVLIR | VCRHKKEAFL | GPILKQMYIM | YVRNCKFTSP | STLPLISFMQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTLTEMLALD | PSVSYQHAFL | YIRQLAVHLR | NAMTTGKKET | HQSVYNWQYV | HCLYLWCRVL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| STLGSSEILQ | PLLYPLSQII | IGCIKLLPTA | RFYPLRMHCV | RALTLLSQTI | GTFIPVLPFI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LEIFQQVDFN | RRPGRMSSKP | INFSVILKLS | STNLQEKAYR | DGLLEQLCDL | ILEYLHSQAH |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SIAFPELVLP | TVLQLKSFLR | ECKVANYCRQ | VRQLLEKVQE | NARHIESLRQ | SATFSVSDRT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AVDAWEKQVR | EEGTPLTRYY | GHWKKLRDRE | IQLEISGKER | LEDLNFPEIK | RRKVEDRKDE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DRKELKDLFE | LDSSEGEDST | DFFERGVPRL | PEAHQGLKED | QEEEDKEEGD | SDSEDGDTDT |
| 730 | 740 | ||||
| GVDLSELWQL | AQGAQDELED | LQLSEED |