Q3SYU1

PR
Gene name
NOC2L (NIR)
Protein name
Nucleolar complex protein 2 homolog
Names
Protein NOC2 homolog, NOC2-like protein, Novel INHAT repressor
Species
Bos taurus (Bovine)
KEGG Pathway
bta:508638
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3SYU1

Entry ID Method Resolution Chain Position Source
AF-Q3SYU1-F1 Predicted AlphaFoldDB

344 variants for Q3SYU1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs481611532 3 A>G No EVA
rs451127550 5 L>V No EVA
rs461477312 6 S>R No EVA
rs460775331 10 R>G No EVA
rs439821244 11 L>P No EVA
rs439821244 11 L>R No EVA
rs463059048 12 E>* No EVA
rs483068728 12 E>A No EVA
rs483068728 12 E>G No EVA
rs448509832 13 E>G No EVA
rs468636218 14 L>P No EVA
rs468636218 14 L>R No EVA
rs479029130 15 T>A No EVA
rs479029130 15 T>P No EVA
rs446784382 16 V>A No EVA
rs446784382 16 V>G No EVA
rs466820684 17 D>G No EVA
rs432161324 18 E>* No EVA
rs468929168 18 E>D No EVA
rs452144402 18 E>G No EVA
rs437623119 19 F>V No EVA
rs474650677 21 A>G No EVA
rs433566327 22 S>A No EVA
rs433566327 22 S>P No EVA
rs439833228 24 F>L No EVA
rs463120314 25 D>G No EVA
rs463120314 25 D>V No EVA
rs476787440 26 S>F No EVA
rs462218553 27 E>A No EVA
rs479098063 27 E>D No EVA
rs462218553 27 E>G No EVA
rs442171291 27 E>K No EVA
rs442171291 27 E>Q No EVA
rs447550634 28 S>A No EVA
rs460457903 28 S>C No EVA
rs445821459 29 E>A No EVA
rs445821459 29 E>G No EVA
rs477080396 29 E>Q No EVA
rs437734236 30 S>L No EVA
rs469041809 30 S>P No EVA
rs469041809 30 S>T No EVA
rs433574427 31 E>G No EVA
rs468233992 31 E>K No EVA
rs453590826 32 P>A No EVA
rs453590826 32 P>T No EVA
rs456808176 33 E>G No EVA
rs433497306 33 E>Q No EVA
rs462261396 35 A>D No EVA
rs519610323 36 P>S No EVA
rs472632154 39 E>A No EVA
rs458033052 40 T>K No EVA
rs441220746 40 T>P No EVA
rs477991718 41 Q>H No EVA
rs134216226 43 V>G No EVA
rs462681525 44 R>S No EVA
rs136036373 46 A>G No EVA
rs448142455 46 A>T No EVA
rs136036373 46 A>V No EVA
rs478718363 47 A>D No EVA
rs478718363 47 A>G No EVA
rs464185372 49 E>D No EVA
rs470437633 55 G>R No EVA
rs470437633 55 G>W No EVA
rs435788459 56 S>G No EVA
rs455831609 56 S>I No EVA
rs472755542 56 S>R No EVA
rs441324243 57 P>H No EVA
rs451756394 58 L>F No EVA
rs471655007 59 A>S No EVA
rs443578440 60 S>C No EVA
rs436385200 62 R>L No EVA
rs455564196 63 K>E No EVA
rs441066008 69 H>N No EVA
rs457897698 69 H>Q No EVA
rs471578745 71 D>A No EVA
rs443373741 73 L>H No EVA
rs480313290 77 K>E No EVA
rs448826619 78 D>A No EVA
rs460000973 80 D>H No EVA
rs460000973 80 D>Y No EVA
rs480118693 86 F>L No EVA
rs445416489 86 F>L No EVA
rs465430109 89 E>K No EVA
rs437357924 92 Q>H No EVA
rs450941659 102 S>R No EVA
rs436390981 118 E>A No EVA
rs717656576 136 G>R No EVA
rs463046862 158 Q>K No EVA
rs483104998 165 F>L No EVA
rs1116815042 174 A>V No EVA
rs137413616 176 V>G No EVA
rs132975843 177 A>G No EVA
rs137179692 179 T>P No EVA
rs448340921 192 Q>R No EVA
rs467728927 229 V>A No EVA
rs467728927 229 V>G No EVA
rs435504944 230 L>M No EVA
rs455625832 230 L>P No EVA
rs472427930 231 Q>K No EVA
rs441006507 231 Q>R No EVA
rs471478937 232 P>A No EVA
rs443214844 232 P>R No EVA
rs463398049 235 S>N No EVA
rs443156609 239 A>S No EVA
rs459865473 241 L>I No EVA
rs479827392 242 R>L No EVA
rs445353953 244 D>G No EVA
rs523942490 246 K>N No EVA
rs482334531 247 A>D No EVA
rs465319633 247 A>S No EVA
rs450875582 249 L>Q No EVA
rs467840595 253 I>L No EVA
rs473854923 256 V>G No EVA
rs452755286 262 A>G No EVA
rs472791315 264 V>M No EVA
rs466179394 265 A>E No EVA
rs439111157 267 A>P No EVA
rs476060095 271 H>P No EVA
rs444546223 271 H>Q No EVA
rs459172797 271 H>Y No EVA
rs461478056 272 V>M No EVA
rs481481895 277 P>A No EVA
rs477395334 287 R>C No EVA
rs445193245 288 M>I No EVA
rs465180182 289 L>V No EVA
rs436992673 290 L>Q No EVA
rs450570987 291 K>M No EVA
rs460205978 307 L>V No EVA
rs440313681 334 T>P No EVA
rs460268864 337 R>G No EVA
rs470778762 337 R>K No EVA
rs439335356 338 N>K No EVA
rs462644286 342 T>P No EVA
rs482733611 346 T>P No EVA
rs448167967 349 L>P No EVA
rs461766401 350 I>L No EVA
rs478600521 351 N>K No EVA
rs448026260 352 F>L No EVA
rs433394384 353 M>I No EVA
rs464819667 353 M>R No EVA
rs450230909 357 L>R No EVA
rs379397381 358 T>K No EVA
rs379397381 358 T>M No EVA
rs470358195 358 T>P No EVA
rs455673806 359 E>K No EVA
rs434703074 362 A>P No EVA
rs470878264 363 L>R No EVA
rs462784558 364 D>A No EVA
rs439400135 364 D>H No EVA
rs476385202 365 T>P No EVA
rs476385202 365 T>S No EVA
rs461829821 367 V>L No EVA
rs437029569 368 A>S No EVA
rs478608502 369 Y>S No EVA
rs458394752 370 Q>H No EVA
rs440814552 370 Q>L No EVA
rs478589771 371 H>P No EVA
rs478589771 371 H>R No EVA
rs450280578 373 F>L No EVA
rs470450351 374 L>R No EVA
rs480614937 375 Y>N No EVA
rs449308308 375 Y>S No EVA
rs466052567 378 Q>E No EVA
rs434766504 378 Q>H No EVA
rs451646274 380 A>S No EVA
rs465304945 385 N>H No EVA
rs433098575 385 N>I No EVA
rs433098575 385 N>T No EVA
rs476444450 387 M>L No EVA
rs441799262 388 T>K No EVA
rs440928953 392 K>R No EVA
rs434605005 393 E>G No EVA
rs444956192 394 T>A No EVA
rs465150912 396 Q>* No EVA
rs436906200 397 S>L No EVA
rs467241364 398 V>G No EVA
rs435908434 403 F>C No EVA
rs453484522 403 F>L No EVA
rs473670704 404 V>M No EVA
rs135409711 405 H>L No EVA
rs135409711 405 H>P No EVA
rs452651372 409 L>P No EVA
rs476047970 411 C>R No EVA
rs476047970 411 C>S No EVA
rs444588566 416 T>S No EVA
rs461406604 417 I>S No EVA
rs440408772 420 S>R No EVA
rs481418521 420 S>T No EVA
rs717710013 422 A>P No EVA
rs459665652 423 L>R No EVA
rs479791639 428 Y>S No EVA
rs445104680 433 V>I No EVA
rs482058305 434 V>G No EVA
rs467253881 435 I>S No EVA
rs435971966 437 C>G No EVA
rs452825137 438 I>M No EVA
rs478638041 440 L>V No EVA
rs441512608 441 V>A No EVA
rs458327574 447 Y>H No EVA
rs478473122 449 L>M No EVA
rs450159627 455 R>L No EVA
rs466228083 458 T>I No EVA
rs449290017 458 T>S No EVA
rs432964633 461 S>A No EVA
rs456365240 461 S>L No EVA
rs476384518 462 E>A No EVA
rs435325939 463 S>C No EVA
rs435325939 463 S>G No EVA
rs455306105 464 T>S No EVA
rs440764900 466 T>P No EVA
rs472106821 467 F>L No EVA
rs443872604 469 P>T No EVA
rs463834751 470 V>L No EVA
rs480608910 471 L>Q No EVA
rs479879049 472 P>L No EVA
rs459744522 472 P>S No EVA
rs445160916 473 F>C No EVA
rs465357374 474 I>M No EVA
rs433077204 475 L>F No EVA
rs469985900 476 E>G No EVA
rs469985900 476 E>V No EVA
rs462533527 478 F>L No EVA
rs483307813 484 N>T No EVA
rs448682718 487 P>S No EVA
rs479211032 488 G>A No EVA
rs464466989 491 S>I No EVA
rs433163800 492 S>P No EVA
rs456402386 495 I>N No EVA
rs470005456 497 F>L No EVA
rs474826464 499 V>E No EVA
rs474826464 499 V>G No EVA
rs454701376 499 V>L No EVA
rs454701376 499 V>M No EVA
rs433742234 503 L>Q No EVA
rs470718513 509 Q>H No EVA
rs439307058 513 Y>* No EVA
rs433920378 520 Q>H No EVA
rs447577499 527 E>G No EVA
rs464369508 528 Y>D No EVA
rs432901201 529 L>Q No EVA
rs456251540 532 Q>P No EVA
rs469833147 533 A>G No EVA
rs435259514 537 A>E No EVA
rs441476321 542 V>A No EVA
rs472218744 542 V>L No EVA
rs451844939 545 A>P No EVA
rs443755508 547 L>V No EVA
rs463771482 548 Q>P No EVA
rs432517272 552 F>C No EVA
rs469510114 555 E>D No EVA
rs452644129 555 E>G No EVA
rs438061385 556 C>G No EVA
rs438061385 556 C>S No EVA
rs454964063 557 K>T No EVA
rs474997087 558 V>G No EVA
rs442722722 559 A>S No EVA
rs453043638 561 Y>S No EVA
rs473034501 562 C>S No EVA
rs382794084 563 R>H No EVA
rs438529804 572 V>G No EVA
rs458561416 576 A>G No EVA
rs481997143 578 H>N No EVA
rs520097401 580 R>C No EVA
rs444090585 586 V>D No EVA
rs460992418 591 S>C No EVA
rs481033438 593 Q>* No EVA
rs447194481 593 Q>L No EVA
rs447194481 593 Q>P No EVA
rs467230890 595 A>E No EVA
rs477681515 596 V>G No EVA
rs452252787 603 T>P No EVA
rs719189223 604 R>Q No EVA
rs475666576 613 Y>S No EVA
rs468531738 614 Y>S No EVA
rs437749938 615 S>T No EVA
rs440128700 628 E>G No EVA
rs460174609 629 I>F No EVA
rs470540316 629 I>S No EVA
rs460174609 629 I>V No EVA
rs439932278 633 E>Q No EVA
rs483253701 634 R>L No EVA
rs458017309 636 E>D No EVA
rs478072745 637 D>E No EVA
rs449893079 638 L>F No EVA
rs466620220 646 R>C No EVA
rs463516136 646 R>L No EVA
rs480386448 648 V>G No EVA
rs435210661 652 K>N No EVA
rs481702673 687 A>G No EVA
rs447102508 689 Q>P No EVA
rs467155158 691 V>G No EVA
rs432454151 692 E>Q No EVA
rs446047341 700 S>R No EVA
rs469421954 705 E>G No EVA
rs454902891 707 V>A No EVA
rs473931803 709 K>T No EVA
rs453028934 710 S>T No EVA
rs438066274 714 S>R No EVA
rs459877365 721 L>M No EVA
rs468399714 721 L>P No EVA
rs468399714 721 L>R No EVA
rs459877365 721 L>V No EVA
rs432141686 722 D>E No EVA
rs473032463 722 D>G No EVA
rs453041600 722 D>N No EVA
rs473032463 722 D>V No EVA
rs452270512 723 P>T No EVA
rs444117976 724 Q>H No EVA
rs475538305 724 Q>P No EVA
rs460950546 725 E>A No EVA
rs460950546 725 E>G No EVA
rs474549416 726 L>P No EVA
rs460807207 727 W>G No EVA
rs477723782 728 Q>E No EVA
rs446233064 728 Q>R No EVA
rs483220433 729 L>P No EVA
rs483220433 729 L>R No EVA
rs463157852 729 L>V No EVA
rs448452126 730 A>G No EVA
rs876121530 731 Q>H No EVA
rs468410216 731 Q>P No EVA
rs468410216 731 Q>R No EVA
rs478786958 733 P>A No EVA
rs478786958 733 P>T No EVA
rs466865792 734 E>G No EVA
rs452262069 735 D>E No EVA
rs432238194 735 D>G No EVA
rs469161538 736 E>G No EVA
rs469161538 736 E>V No EVA
rs454594190 737 L>V No EVA
rs474613113 738 Q>E No EVA
rs440065432 738 Q>H No EVA
rs474613113 738 Q>K No EVA
rs453703939 739 D>A No EVA
rs453703939 739 D>G No EVA
rs453703939 739 D>V No EVA
rs471318147 740 L>P No EVA
rs439873307 741 Q>* No EVA
rs463123745 741 Q>L No EVA
rs463123745 741 Q>P No EVA
rs463123745 741 Q>R No EVA
rs462047505 746 D>E No EVA
rs442097266 746 D>G No EVA
rs478899571 747 D>R No EVA

No associated diseases with Q3SYU1

No regional properties for Q3SYU1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q3SYU1

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleoplasm
  • Nucleus, nucleolus
  • Translocates from the nucleoli to the nucleoplasm in presence of several stressors like ultraviolet irradiation and actinomycin-D
  • Predominantly detected in the nucleoli in non-mitotic cells
  • Predominantly detected in nucleoplasma in cells undergoing mitosis (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Noc1p-Noc2p complex A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.
Noc2p-Noc3p complex A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

4 GO annotations of molecular function

Name Definition
DNA-binding transcription factor binding Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

7 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
cellular response to UV Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
negative regulation of B cell apoptotic process Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.
negative regulation of histone acetylation Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
negative regulation of intrinsic apoptotic signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39744 NOC2 Nucleolar complex protein 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9VIF0 CG9246 Nucleolar complex protein 2 homolog Drosophila melanogaster (Fruit fly) PR
Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog Homo sapiens (Human) PR
Q9WV70 Noc2l Nucleolar complex protein 2 homolog Mus musculus (Mouse) PR
O17580 pro-2 Nucleolar complex protein 2 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MAAALSRKRR LEELTVDEFL ASGFDSESES EPEGAPEAET QAVRAAAREP DGPGGSPLAS
70 80 90 100 110 120
RRKGGASEHK DQLSRLKDKD PEFYKFLQEN DQSLLNFSDS DSSEDEEEQL HSLPNMLEEA
130 140 150 160 170 180
SEEEEEEDGV PRGPEGKRRD SVPVTLAMVE KWKQAAKQHL TPKLFHEVVQ AFRAAVATTQ
190 200 210 220 230 240
GDEEGAETSK FQVTDSAVFN ALVTFCIRDL FGCLQKLLFG KAPKDSSRVL QPSSSPLWAK
250 260 270 280 290 300
LRLDVKAYLS SVIQLVACVA EATVAAAILQ HVGSSVPYYL TFPKQCRMLL KRMVVLWSTG
310 320 330 340 350 360
EETLRVLAFV VLIKVCRHKK DVFLSPVLKQ MYITYVRNCK FTSPSTLPLI NFMQRTLTEL
370 380 390 400 410 420
LALDTGVAYQ HAFLYIRQLA IHLRNAMTTR RKETYQSVYN WQFVHCLYLW CRALSTICPS
430 440 450 460 470 480
EALQPLIYPL SQVVIGCIKL VPTARFYPLR MHCVRALTLL SESTGTFIPV LPFILEIFQQ
490 500 510 520 530 540
VDFNRRPGRI SSRPINFAVI LKLSKVNLQE KAYRDGLVEQ LYDLTLEYLH SQAHSIAFPE
550 560 570 580 590 600
LVLPAVLQLK SFLRECKVAN YCRQVRQLLE KVQENAEHIR SVRQKVSFGV SDQRAVDAWE
610 620 630 640 650 660
KRTREEGTPL TKYYSQWRKL RDREIQLEIS GKERLEDLNF PEVKRRKVGD RKDEDRAEFK
670 680 690 700 710 720
DLFDLESDDE DDAPDFTKRG MPGSPGAWQK VEEEDDDSSS SSGEEEVSKS EDGSPDTEAG
730 740
LDPQELWQLA QGPEDELQDL QLSEED