O17580

PR
Gene name
pro-2 (C07E3.2)
Protein name
Nucleolar complex protein 2 homolog
Names
Protein NOC2 homolog, Proximal proliferation in germline protein 2
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C07E3.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-171 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O17580

Entry ID Method Resolution Chain Position Source
AF-O17580-F1 Predicted AlphaFoldDB

No variants for O17580

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O17580

No associated diseases with O17580

No regional properties for O17580

Type Name Position InterPro Accession
No domain, repeats, and functional sites for O17580

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Noc1p-Noc2p complex A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.
Noc2p-Noc3p complex A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

5 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
gonadal mesoderm development The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.
negative regulation of histone acetylation Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39744 NOC2 Nucleolar complex protein 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SYU1 NOC2L Nucleolar complex protein 2 homolog Bos taurus (Bovine) PR
Q9VIF0 CG9246 Nucleolar complex protein 2 homolog Drosophila melanogaster (Fruit fly) PR
Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog Homo sapiens (Human) PR
Q9WV70 Noc2l Nucleolar complex protein 2 homolog Mus musculus (Mouse) PR
10 20 30 40 50 60
MKLLKKPAGL KKRKVISKRI KIEKKPSSED EGSSDEEVPK LDGEGSLDGS EDEDDGTVTV
70 80 90 100 110 120
EKGGVKKHKL DLEKLKQSDP EFFKFLQQED ADLLNMEDDG DDDEDDDEDD EDEEEEESDD
130 140 150 160 170 180
DEDDEEDDDK TKIKKIRKPK IKSDNSGRLI VDSNVYSYLQ QVLVLDDETS TPTNPSDVRM
190 200 210 220 230 240
AVDVFVACVA RVGADIEAPK YVINEQSIFE AVVRMCFQAM PDILKRLLKA KPEGDKVLFS
250 260 270 280 290 300
KTAIKKYQTY VRTYLHAMIV FLNEVQTTEV LIATIKAMTR LVDLYAHFSR MSKLLIKAVV
310 320 330 340 350 360
RIWSRKTLEC RLPAFVCMNL LVKNYPQHFV PLYKTAYVAF VANSKIVTNE TWPLLQFMHR
370 380 390 400 410 420
TFAELTILNP EQAYKYAFVY IRQTAVHLRN AMISKGRKDL IFSIYNWQMM QCMYMWVRVI
430 440 450 460 470 480
AKAHSVNGAE QIGELVYPLI QVIVGIFKLC NAPTFLPLRL HCCQLLIQLQ ASCTNYIPIL
490 500 510 520 530 540
QVSCDCLEEL ARELKSKPKP VKGAVKLPDI ECTLKCSSQF SDLPQWRKVI SEHVFRTMMQ
550 560 570 580 590 600
SAHLLASQAA FPDVVLPINH RISAILETMK NGDHAHLFRG FQTKLKEHSR FVLDVLARKS
610 620 630 640 650 660
VDINDEMQVR AVRFDLNNPD SPIKTFYRQW EKVWKMKERS AVENSKKDDK KKKKEEEAAA
670 680 690 700 710
AKKRKPNETV EDEDDVKPEV SKAKRKRIKI GAAAKKADAS VPDQFADMSM WSDED