P39744

PR
Gene name
NOC2 (YOR206W, YOX001)
Protein name
Nucleolar complex protein 2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOR206W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-223 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P39744

Entry ID Method Resolution Chain Position Source
7NAC EM 304 A 8 1-710 PDB
7NAD EM 304 A 8 1-710 PDB
7NAF EM 313 A 8 3-41 PDB
7R6K EM 317 A 8 1-710 PDB
7R72 EM 307 A 8 1-710 PDB
7R7A EM 304 A 8 1-710 PDB
8E5T EM 400 A 6 1-710 PDB
AF-P39744-F1 Predicted AlphaFoldDB

8 variants for P39744

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-727573 21 D>H No SGRP
s15-727651 47 D>N No SGRP
s15-727789 93 T>P No SGRP
s15-727970 153 G>D No SGRP
s15-728591 360 T>K No SGRP
s15-729387 625 I>M No SGRP
s15-729484 658 S>A No SGRP
s15-729633 707 M>I No SGRP

No associated diseases with P39744

No regional properties for P39744

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P39744

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
Noc1p-Noc2p complex A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.
Noc2p-Noc3p complex A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

1 GO annotations of molecular function

Name Definition
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.

2 GO annotations of biological process

Name Definition
ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SYU1 NOC2L Nucleolar complex protein 2 homolog Bos taurus (Bovine) PR
Q9VIF0 CG9246 Nucleolar complex protein 2 homolog Drosophila melanogaster (Fruit fly) PR
Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog Homo sapiens (Human) PR
Q9WV70 Noc2l Nucleolar complex protein 2 homolog Mus musculus (Mouse) PR
O17580 pro-2 Nucleolar complex protein 2 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MGKVSKSTKK FQSKHLKHTL DQRRKEKIQK KRIQGRRGNK TDQEKADAAG TREQQQLKKS
70 80 90 100 110 120
AKEEVFKDMS VETFFEKGIE IPKENKKLKK KTTKEQSDED SSSSEEEEDM GQSMAKLAEK
130 140 150 160 170 180
DPEFYKYLEE NDKDLLDFAG TNPLDGIDSQ DEGEDAERNS NIEEKSEQME LEKEKIELSL
190 200 210 220 230 240
KLVRKWKKQL HDSPSLKLLR NIISAFKVAV NLNKEENIED YKYAITDEKA FHELMFMVLK
250 260 270 280 290 300
DVPQAIQKMA PYKIVKGART LPNGGNVSRV SSIVKSHAGS LLILLNDITN TETAALVLHS
310 320 330 340 350 360
VNELMPYLLS YRRILKELIK SIVGVWSTTR ELETQIASFA FLINTTKEFK KSMLETTLKT
370 380 390 400 410 420
TYSTFIKSCR KTNMRSMPLI NFQKNSAAEL FGIDEVLGYQ VGFEYIRQLA IHLRNTMNAT
430 440 450 460 470 480
TKKSSKINSA EAYKIVYNWQ FCHSLDFWSR VLSFACQPEK ENGSESPLRQ LIYPLVQVTL
490 500 510 520 530 540
GVIRLIPTPQ FFPLRFYLIK SLIRLSQNSG VFIPIYPLLS EILTSTAFTK APKKSPNLAA
550 560 570 580 590 600
FDFEHNIKCT QAYLNTKIYQ EGLSEQFVDL LGDYFALYCK NIAFPELVTP VIISLRRYIK
610 620 630 640 650 660
TSTNVKLNKR LSTVVEKLNQ NSTFIQEKRS DVEFGPTNKS EVSRFLNDVA WNKTPLGSYV
670 680 690 700
AVQREVKEEK ARLMRESMEE QDKERETEEA KLLNSLESDD DNEDVEMSDA