Q9VIF0

PR
Gene name
CG9246
Protein name
Nucleolar complex protein 2 homolog
Names
Protein NOC2 homolog
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG9246
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-163 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9VIF0

Entry ID Method Resolution Chain Position Source
AF-Q9VIF0-F1 Predicted AlphaFoldDB

No variants for Q9VIF0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q9VIF0

No associated diseases with Q9VIF0

No regional properties for Q9VIF0

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q9VIF0

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
Noc1p-Noc2p complex A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.
Noc2p-Noc3p complex A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

2 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
transcription corepressor activity A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

3 GO annotations of biological process

Name Definition
negative regulation of histone acetylation Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39744 NOC2 Nucleolar complex protein 2 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SYU1 NOC2L Nucleolar complex protein 2 homolog Bos taurus (Bovine) PR
Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog Homo sapiens (Human) PR
Q9WV70 Noc2l Nucleolar complex protein 2 homolog Mus musculus (Mouse) PR
O17580 pro-2 Nucleolar complex protein 2 homolog Caenorhabditis elegans PR
10 20 30 40 50 60
MKLATKKIKT LGKSKPDLSK KKPAKDAIRK TKPQTTSETK VTPRNPKQKV AEPVKNGKTT
70 80 90 100 110 120
KKGFKKSHKE ELEGLKDIDP EFYDFLKNND KKLLDFNLLD TDDDDDEEGD EEDKEDTVTK
130 140 150 160 170 180
ESKDDEDDEE KYHKPSKDLE VASDESDFEV DEEDDAAAGG IQKITLNLLH QWEQQLGQAN
190 200 210 220 230 240
ISIDIVRKVI QAFNSALASI SADGADGGEN KHNAAAFKVV GAAAFNGVIQ LCVIHLQPAI
250 260 270 280 290 300
IRLLGVRPNS SLPLHKHKKW VKVRGCLRYY LTDLIRLVEQ VSSPNILGVL LKHLHQMAGM
310 320 330 340 350 360
VVPFSALGKT ILKRLVVLWS TGDETVRVLA FLCILKITRK QQATMLNHVL KAMYLAYVRN
370 380 390 400 410 420
SKFVSPNTLP GINFMRRSLV EMFALDLNVS YQHVFLYIRQ LAIHLRNAVI LKKKDSFQAV
430 440 450 460 470 480
YNWQFINSLR LWADLLGASA NKPQLQPLIY PLVTIATGVI RLIPTAQYFP LRFHCLQTLI
490 500 510 520 530 540
SLAKETNTYV PVLPLIVEVL KSNTFNRKHS AVSMKPVQFT CVLRLNKGQL AENGFRDEVI
550 560 570 580 590 600
EQVCGLLLEY LAHESTSLAF SDLVVPTVMA IKTYLKECRN ANYARKLKQL LEKIQESARF
610 620 630 640 650 660
IEQQRGKSSV TFDIKDAQAV AAWEQQLRLK RTPLDVYYAS WLKTHETKKR RQAAHTDEIN
670 680 690 700 710 720
ADYDVPKLKK LPVKTGVPVR NENGEVELFP SDSEDEGDDG LHLGSDDDDD EDVQEEEEVE
730 740 750 760
VEHPKAKKAK KEKPEKQKPR PATVEDDYDE AGGAVDIVKD LDLNEW