Q9WUM4
PR
Gene name |
Coro1c |
Protein name |
Coronin-1C |
Names |
Coronin-3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:23790 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9WUM4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9WUM4-F1 | Predicted | AlphaFoldDB |
28 variants for Q9WUM4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388779724 | 6 | R>G | No | EVA | |
| rs260853387 | 11 | R>S | No | EVA | |
| rs3388752599 | 75 | T>S | No | EVA | |
| rs3388779775 | 91 | H>L | No | EVA | |
| rs3388779742 | 92 | N>S | No | EVA | |
| rs3388776983 | 125 | I>F | No | EVA | |
| rs3388776927 | 148 | S>C | No | EVA | |
| rs3388782398 | 175 | D>Y | No | EVA | |
| rs3388762940 | 196 | K>E | No | EVA | |
| rs3388773483 | 213 | E>K | No | EVA | |
| rs3395669825 | 216 | H>R | No | EVA | |
| rs3388777444 | 224 | A>P | No | EVA | |
| rs3388785837 | 237 | F>L | No | EVA | |
| rs3388779759 | 254 | Q>* | No | EVA | |
| rs3396011546 | 261 | E>V | No | EVA | |
| rs3388766518 | 267 | G>R | No | EVA | |
| rs3388787037 | 291 | R>L | No | EVA | |
| rs3388770645 | 299 | S>T | No | EVA | |
| rs3388773474 | 300 | P>S | No | EVA | |
| rs3388773521 | 301 | Y>H | No | EVA | |
| rs3388787049 | 302 | V>L | No | EVA | |
| rs3388770640 | 364 | D>E | No | EVA | |
| rs3388782642 | 381 | K>N | No | EVA | |
| rs3388782162 | 404 | V>M | No | EVA | |
| rs3388773519 | 420 | S>I | No | EVA | |
| rs266164145 | 425 | A>D | No | EVA | |
| rs3388782591 | 435 | V>M | No | EVA | |
| rs1132228360 | 461 | R>C | No | EVA |
No associated diseases with Q9WUM4
No regional properties for Q9WUM4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9WUM4 | |||
Functions
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cytoskeleton | The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| flotillin complex | A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. |
| lamellipodium | A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. |
| lateral plasma membrane | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. |
| ruffle membrane | The portion of the plasma membrane surrounding a ruffle. |
| vesicle | Any small, fluid-filled, spherical organelle enclosed by membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| small GTPase binding | Binding to a small monomeric GTPase. |
25 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cortical patch assembly | Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells. |
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| corpus callosum development | The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. |
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| endosome fission | The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. |
| endosome membrane tubulation | A membrane tubulation process occurring in an endosome membrane. |
| establishment of protein localization | The directed movement of a protein to a specific location. |
| membrane fission | A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. |
| negative regulation of epithelial cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration. |
| negative regulation of focal adhesion assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
| negative regulation of protein kinase activity by regulation of protein phosphorylation | The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase. |
| negative regulation of protein phosphorylation | Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein. |
| negative regulation of substrate adhesion-dependent cell spreading | Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading. |
| neural crest cell migration | The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| positive regulation of lamellipodium morphogenesis | Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis. |
| regulation of epithelial cell migration | Any process that modulates the frequency, rate or extent of epithelial cell migration. |
| regulation of fibroblast migration | Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium. |
| regulation of focal adhesion assembly | Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions. |
| regulation of protein phosphorylation | Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. |
| regulation of ruffle assembly | Any process that modulates the frequency, rate or extent of ruffle assembly. |
| regulation of substrate adhesion-dependent cell spreading | Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q06440 | CRN1 | Coronin-like protein | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q6QEF8 | CORO6 | Coronin-6 | Homo sapiens (Human) | PR |
| Q9UQ03 | CORO2B | Coronin-2B | Homo sapiens (Human) | PR |
| Q9ULV4 | CORO1C | Coronin-1C | Homo sapiens (Human) | PR |
| Q9WUM3 | Coro1b | Coronin-1B | Mus musculus (Mouse) | PR |
| Q9D2V7 | Coro7 | Coronin-7 | Mus musculus (Mouse) | PR |
| Q920M5 | Coro6 | Coronin-6 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRRVVRQSKF | RHVFGQAVKN | DQCYDDIRVS | RVTWDSSFCA | VNPRFVAIII | EASGGGAFLV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPLHKTGRID | KSYPTVCGHT | GPVLDIDWCP | HNDQVIASGS | EDCTVMVWQI | PENGLTLSLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EPVVILEGHS | KRVGIVAWHP | TARNVLLSAG | CDNAIIIWNV | GTGEALINLD | DMHSDMIYNV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SWSRNGSLIC | TASKDKKVRV | IDPRKQEIVA | EKEKAHEGAR | PMRAIFLADG | NVFTTGFSRM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SERQLALWNP | KNMQEPIALH | EMDTSNGVLL | PFYDPDTSII | YLCGKGDSSI | RYFEITDESP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YVHYLNTFSS | KEPQRGMGYM | PKRGLDVNKC | EIARFFKLHE | RKCEPIIMTV | PRKSDLFQDD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LYPDTAGPEA | ALEAEEWFEG | KNADPILISL | KHGYIPGKNR | DLKVVKKNIL | DSKPAANKKS |
| 430 | 440 | 450 | 460 | 470 | |
| ELSCAPKKPT | DTASVQNEAK | LDEILKEIKS | IKETICSQDE | RISKLEQQLA | KMAA |