AiPD: Autoinhibited Protein Database

Q9ULV4

Gene name	CORO1C
Protein name	Coronin-1C
Names	Coronin-3, hCRNN4
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23603
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

369-474 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

369-474 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q9ULV4

Entry ID	Method	Resolution	Chain	Position	Source
7STY	X-ray	200 A	A	1-474	PDB
AF-Q9ULV4-F1	Predicted				AlphaFoldDB

263 variants for Q9ULV4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA386426918 rs1443351239	2	R>W		No	ClinGen gnomAD
CA6769786 rs775764847	3	R>Q		No	ClinGen ExAC gnomAD
rs938322744 CA243323774	6	R>*		No	ClinGen TOPMed gnomAD
TCGA novel	16	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6769784 rs746178396	17	A>V		No	ClinGen ExAC TOPMed gnomAD
rs749438076 CA6769781	20	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1228297487 CA386426453	23	C>W		No	ClinGen TOPMed
CA6769779 rs756341452	24	Y>C		No	ClinGen ExAC gnomAD
rs1467868723 CA386426420	25	D>E		No	ClinGen gnomAD
CA243323740 rs1024262412	28	R>Q		No	ClinGen TOPMed gnomAD
CA243323746 rs969575661	28	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1005739501 CA243323735	29	V>G		No	ClinGen Ensembl
rs1592926914 CA386426303	31	R>C		No	ClinGen Ensembl
rs888712529 CA243323711	31	R>H		No	ClinGen TOPMed gnomAD
CA386426292 rs888712529	31	R>L		No	ClinGen TOPMed gnomAD
CA386426156 rs750188850	36	S>N		No	ClinGen ExAC gnomAD
CA6769775 rs750188850	36	S>T		No	ClinGen ExAC gnomAD
rs765274212 CA6769774	43	P>A		No	ClinGen ExAC gnomAD
rs1460998704 CA386425977	43	P>L		No	ClinGen gnomAD
CA6769773 rs761834366	44	R>G		No	ClinGen ExAC gnomAD
rs373612252 CA243323698	47	A>S		No	ClinGen Ensembl
rs1189989304 CA386425877	48	I>V		No	ClinGen TOPMed
CA6769771 rs760283072	50	I>L		No	ClinGen ExAC gnomAD
CA6769770 rs760283072	50	I>V		No	ClinGen ExAC gnomAD
rs1387758382 CA386425817	51	E>Q		No	ClinGen TOPMed
CA386425748 rs1295016751	53	S>R		No	ClinGen TOPMed gnomAD
CA6769769 rs775238496	54	G>R		No	ClinGen ExAC gnomAD
rs1383483635 CA386425692	56	G>R		No	ClinGen gnomAD
rs759957370 CA6769767	57	A>T		No	ClinGen ExAC TOPMed gnomAD
rs764153352 CA243323676	57	A>V		No	ClinGen TOPMed gnomAD
rs771485925 CA6769765	59	L>F		No	ClinGen ExAC gnomAD
rs749773615 CA6769764	60	V>D		No	ClinGen ExAC gnomAD
rs1436061926 CA386425582	61	L>F		No	ClinGen TOPMed
CA243323642 rs200628009	64	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA243323646 rs900886204	64	H>Y		No	ClinGen Ensembl
CA386425480 rs1182338509	65	K>R		No	ClinGen gnomAD
TCGA novel	68	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6769741 rs768976029	69	I>V		No	ClinGen ExAC gnomAD
rs1314957455 CA386444392	70	D>E		No	ClinGen gnomAD
rs747208725 CA6769740	71	K>I		No	ClinGen ExAC gnomAD
CA6769739 rs778889131	73	Y>H		No	ClinGen ExAC gnomAD
CA6769736 rs117058530	75	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386444327 rs1384676588	80	T>R		No	ClinGen gnomAD
CA243350465 rs11547298	85	D>Y		No	ClinGen Ensembl
CA6769734 rs191589715	86	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386444259 rs1592890172	90	P>L		No	ClinGen Ensembl
CA6769732 rs146817658	91	H>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA6769731 rs146817658	91	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1427212967 CA386444244	93	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs763324140 CA6769729	95	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6769727 rs765842597	99	G>S		No	ClinGen ExAC gnomAD
rs1206864121 CA386444198	99	G>V		No	ClinGen TOPMed gnomAD
rs541618407 CA6769726	104	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs541618407 CA243350419	104	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs577646346 CA6769723	105	V>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA386443227 rs1478317750	107	V>E		No	ClinGen TOPMed
TCGA novel	107	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6769712 rs758037945	110	I>V		No	ClinGen ExAC gnomAD
rs1252572081 CA386443197	111	P>L		No	ClinGen gnomAD
CA243340822 rs267603290	111	P>S		No	ClinGen Ensembl
rs1225796476 CA386443187	113	N>D		No	ClinGen gnomAD
CA386443182 CA6769710 rs200803526	113	N>K		No	ClinGen 1000Genomes ExAC gnomAD
CA386443184 rs1326393523	113	N>S		No	ClinGen gnomAD
CA386443173 rs1173290958	115	L>F		No	ClinGen TOPMed
rs754336284 CA6769708	118	S>A		No	ClinGen ExAC gnomAD
CA386443153 rs1371796535	118	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs764648940 CA6769707	119	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1166234458 CA386443137	121	E>V		No	ClinGen gnomAD
CA386443134 rs1164384345	122	P>T		No	ClinGen TOPMed
CA386443127 rs1460366791	123	V>L		No	ClinGen gnomAD
CA386443117 rs1389457662	124	V>G		No	ClinGen gnomAD
TCGA novel	131	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs576110387 CA6769703	133	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA6769700 rs769507594	134	G>D		No	ClinGen ExAC gnomAD
CA6769701 rs773099874	134	G>S		No	ClinGen ExAC TOPMed gnomAD
CA6769698 rs368484021	136	V>M		No	ClinGen ESP ExAC gnomAD
CA243340701 rs138291345	137	A>G		No	ClinGen ESP TOPMed
rs201309864 CA6769697	137	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs1401559935 CA386443017	140	P>T		No	ClinGen TOPMed
CA6769695 rs779523160	141	T>A		No	ClinGen ExAC gnomAD
CA6769694 rs374947613	141	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs147020690 CA6769691	143	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs147020690 CA386443000	143	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs754176044 CA6769690	143	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA386442998 rs754176044	143	R>L		No	ClinGen ExAC TOPMed gnomAD
CA6769689 rs141302762	144	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1489079711 CA386442982	146	L>F		No	ClinGen TOPMed
TCGA novel	147	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1315437010 CA386442968	148	S>T		No	ClinGen TOPMed gnomAD
TCGA novel	153	N>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386442603 rs1565904766	155	I>L		No	ClinGen Ensembl
CA386442565 rs1449085071	160	V>M		No	ClinGen gnomAD
CA6769672 rs778270031	161	G>E		No	ClinGen ExAC gnomAD
rs756734816 CA6769671	162	T>K		No	ClinGen ExAC gnomAD
CA6769670 rs753288003	165	A>T		No	ClinGen ExAC gnomAD
TCGA novel	168	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386442494 rs1221743900	171	D>N		No	ClinGen gnomAD
rs766574976 CA6769666 CA386442480	172	M>I		No	ClinGen ExAC gnomAD
CA6769667 rs751589060	172	M>T		No	ClinGen ExAC gnomAD
CA386442477 rs1346681223	173	H>Y		No	ClinGen gnomAD
CA6769665 CA386442459 rs763221290	175	D>E		No	ClinGen ExAC gnomAD
rs776455083 CA6769664	176	M>T		No	ClinGen ExAC gnomAD
rs998043139 CA243338261	177	I>V		No	ClinGen TOPMed
rs763842145 CA6769663	178	Y>C		No	ClinGen ExAC gnomAD
CA386442436 rs1358914865	179	N>D		No	ClinGen TOPMed
rs1208573482 CA386442427	180	V>M		No	ClinGen TOPMed
rs771989893 CA6769660 COSM691378	184	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6769661 rs143115944	184	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1190639626 CA386442300	190	C>S		No	ClinGen TOPMed
rs1386317335 CA386442277	192	A>T		No	ClinGen gnomAD
rs1240684413 CA386442251	194	K>E		No	ClinGen gnomAD
rs1188357177 CA386442237	195	D>N		No	ClinGen gnomAD
CA386442193 rs1188518761	197	K>N		No	ClinGen TOPMed
rs1369909837 CA386442145	201	I>T		No	ClinGen TOPMed
CA243338231 rs547733644	202	D>H		No	ClinGen Ensembl
CA6769655 rs777526999	203	P>L		No	ClinGen ExAC
CA6769654 rs756569073	204	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1273817764 CA386442066	207	E>A		No	ClinGen gnomAD
CA386442048 rs1456255882	208	I>M		No	ClinGen TOPMed
rs1215018253 CA386442052	208	I>T		No	ClinGen gnomAD
CA6769638 rs773011352	211	E>Q		No	ClinGen ExAC gnomAD
CA386441893 rs1305888203	212	K>T		No	ClinGen gnomAD
TCGA novel	213	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA243337338 rs371061578	213	E>K		No	ClinGen ESP TOPMed
CA6769637 rs368890006	214	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	216	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1592853741 CA386441782	220	R>S		No	ClinGen Ensembl
rs377185786 CA6769636	222	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	223	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386441748 rs1164211204	225	I>V		No	ClinGen TOPMed
rs1292307168 CA386441717 COSM546227	229	D>N	lung Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA6769634 rs769089003	231	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1592853676 CA386441648	234	T>P		No	ClinGen Ensembl
rs747515987 CA6769633	235	T>N		No	ClinGen ExAC gnomAD
rs1352333501 CA386441580	239	R>C		No	ClinGen TOPMed gnomAD
CA6769630 rs750447950	239	R>H		No	ClinGen ExAC gnomAD
TCGA novel	240	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6769629 rs557390202	240	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs767321878 CA6769626	243	R>Q		No	ClinGen ExAC gnomAD
rs1408954500 CA386441501	244	Q>H		No	ClinGen gnomAD
rs1179212552 CA386441472	247	L>V		No	ClinGen gnomAD
rs762555895	250	P>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs899312118 CA243337278	250	P>A		No	ClinGen Ensembl
CA6769623 rs766170351	250	P>L		No	ClinGen ExAC TOPMed gnomAD
CA386440782 rs1455798846	252	N>K		No	ClinGen gnomAD
CA386440762 rs1388155074	255	E>K		No	ClinGen gnomAD
rs372309959 CA6769600	257	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1293856062 CA386440645	262	M>I		No	ClinGen TOPMed
rs1470992750 CA386440625	264	T>A		No	ClinGen gnomAD
CA6769597 rs761109962	273	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA6769596 rs761109962	273	Y>F		No	ClinGen ExAC TOPMed gnomAD
CA386440460 rs1221759899	277	T>S		No	ClinGen TOPMed
rs772627304 CA6769594	278	S>G		No	ClinGen ExAC gnomAD
rs567311731 CA6769593	279	I>V		No	ClinGen 1000Genomes ExAC gnomAD
CA386440442 rs1261458680	280	I>L		No	ClinGen TOPMed
rs1486957890 CA386440420	283	C>R		No	ClinGen TOPMed
CA243334114 rs202229272	289	S>G		No	ClinGen 1000Genomes gnomAD
CA386440357 rs1338951699	290	I>V		No	ClinGen TOPMed gnomAD
CA243334113 rs370648888	291	R>H		No	ClinGen ESP TOPMed gnomAD
CA6769572 rs376458929	296	T>M		No	ClinGen ESP ExAC gnomAD
CA386440310 rs1427756412	297	D>Y		No	ClinGen gnomAD
CA6769570 rs770102962	298	E>A		No	ClinGen ExAC gnomAD
CA243334094 rs926385935	299	S>F		No	ClinGen TOPMed
rs1241976210 CA386440285	300	P>L		No	ClinGen TOPMed
rs1366317082 CA386440272	302	V>A		No	ClinGen gnomAD
rs1044676702 CA243334093	304	Y>H		No	ClinGen TOPMed
CA386440228 rs1253356664	308	F>L		No	ClinGen gnomAD
CA6769567 rs758285909	310	S>T		No	ClinGen ExAC TOPMed gnomAD
rs145325902 CA243334085	311	K>Q		No	ClinGen ESP
CA386440195 rs1327464387	313	P>S		No	ClinGen TOPMed
CA386440151 rs1248600245	319	Y>C		No	ClinGen gnomAD
CA386440136 rs1565899950	321	P>S		No	ClinGen Ensembl
CA243334040 rs1008226184	324	G>V		No	ClinGen Ensembl
CA243334036 rs569054483	325	L>F		No	ClinGen 1000Genomes
rs1444705167 CA386440106	326	D>H		No	ClinGen TOPMed
CA386440054 rs1337553123	333	A>S		No	ClinGen gnomAD
rs371483646 CA6769545	336	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1400881928 CA386439043	336	F>L		No	ClinGen gnomAD
CA386438972 rs1565898117	341	R>G		No	ClinGen Ensembl
rs749151089 CA6769544	344	E>K		No	ClinGen ExAC gnomAD
rs755602768 CA6769542	346	I>L		No	ClinGen ExAC TOPMed gnomAD
CA6769543 rs755602768	346	I>V		No	ClinGen ExAC TOPMed gnomAD
CA386438881 rs1216076344	347	I>V		No	ClinGen TOPMed
rs1477329397 CA386438850	349	T>I		No	ClinGen gnomAD
CA6769541 rs200269891	349	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs765734485 CA6769518	366	A>E		No	ClinGen ExAC gnomAD
CA6769519 rs758701110	366	A>S		No	ClinGen ExAC gnomAD
rs765734485 CA6769517	366	A>V		No	ClinGen ExAC gnomAD
rs762661543 CA6769511	371	A>S		No	ClinGen ExAC gnomAD
rs762661543 CA6769510	371	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM1202096 CA6769509 rs370047520	371	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1233541269 CA386438443	376	E>D		No	ClinGen gnomAD
CA6769507 rs748045938	376	E>Q		No	ClinGen ExAC gnomAD
CA6769505 rs368084474	379	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA243331364 rs977678351	380	G>S		No	ClinGen TOPMed
CA386438350 rs1272153455	382	N>K		No	ClinGen gnomAD
CA386438345 rs1204150990	383	A>S		No	ClinGen TOPMed gnomAD
rs1204150990 CA386438346	383	A>T		No	ClinGen TOPMed gnomAD
CA386438327 CA386438325 rs1322175008	384	D>E		No	ClinGen TOPMed gnomAD
CA6769503 rs779575841	386	I>V		No	ClinGen ExAC TOPMed gnomAD
CA386438291 rs1288460562	387	L>F		No	ClinGen gnomAD
CA243331305 rs904124915	388	I>V		No	ClinGen Ensembl
rs374868395 CA6769501	391	K>T		No	ClinGen ESP ExAC TOPMed
CA386438216 rs1369218702	392	H>D		No	ClinGen gnomAD
rs757883118 CA6769499	393	G>R		No	ClinGen ExAC gnomAD
rs754430834 CA6769498	393	G>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs757883118 CA386438200	393	G>W		No	ClinGen ExAC gnomAD
rs964080030 CA243331266	395	I>L		No	ClinGen TOPMed gnomAD
rs371940032 CA243331244	401	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA
CA386438007 rs1471679935	403	K>R		No	ClinGen TOPMed gnomAD
rs1471679935 CA386438010	403	K>T		No	ClinGen TOPMed gnomAD
CA386437981 rs1173325191	404	V>A		No	ClinGen TOPMed
rs1406252513 CA386437992	404	V>M		No	ClinGen TOPMed gnomAD
TCGA novel	406	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1181439169 CA386437946	406	K>T		No	ClinGen gnomAD
CA386437865 rs1266995314	410	L>V		No	ClinGen gnomAD
CA386437827 rs1218869740	412	S>N		No	ClinGen TOPMed gnomAD
CA6769492 rs757195237	414	P>R		No	ClinGen ExAC TOPMed
CA386437751 rs765047650	415	T>I		No	ClinGen ExAC gnomAD
CA6769490 rs765047650	415	T>S		No	ClinGen ExAC gnomAD
rs913606663 CA243331223	416	A>V		No	ClinGen Ensembl
rs761544630 CA6769489	417	N>D		No	ClinGen ExAC gnomAD
CA386437718 rs1374726121	417	N>K		No	ClinGen gnomAD
CA6769488 rs776558672	418	K>Q		No	ClinGen ExAC gnomAD
CA386437710 rs1288260170	418	K>R		No	ClinGen gnomAD
rs768511383 CA6769487	421	D>N		No	ClinGen ExAC gnomAD
rs991919716 CA243331190	424	S>G		No	ClinGen Ensembl
CA386437615 rs1457553485	426	P>A		No	ClinGen gnomAD
rs191109349 CA6769484	426	P>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1161699910 CA386437603	427	K>R		No	ClinGen gnomAD
CA6769483 rs745506701	430	T>R		No	ClinGen ExAC gnomAD
CA6769482 rs368475426	432	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA243331155 rs962633522	433	A>D		No	ClinGen Ensembl
CA6769480 rs749607320	434	S>G		No	ClinGen ExAC gnomAD
CA6769479 rs778431340	434	S>T		No	ClinGen ExAC gnomAD
CA6769478 rs139386424	435	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1463295905 CA386437299	436	Q>*		No	ClinGen gnomAD
rs151306281 CA6769464	439	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA386437192 rs1428390853	442	D>Y		No	ClinGen TOPMed
rs780890146 CA243330245	443	E>D		No	ClinGen TOPMed gnomAD
rs1254763783 CA386437144	444	I>T		No	ClinGen gnomAD
TCGA novel	447	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386437070 rs1233174795	448	I>V		No	ClinGen gnomAD
CA6769462 rs778259532	449	K>I		No	ClinGen ExAC gnomAD
rs1361453044 CA386437011	450	S>A		No	ClinGen TOPMed
TCGA novel	450	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA386436932 rs1364697451	452	K>R		No	ClinGen gnomAD
CA6769460 rs748719946	454	T>I		No	ClinGen ExAC gnomAD
CA386436869 rs1397851166	455	I>T		No	ClinGen gnomAD
CA386436881 rs1421261636	455	I>V		No	ClinGen TOPMed
CA6769459 rs781501120	456	C>F		No	ClinGen ExAC gnomAD
rs1296059268 CA386436829	457	N>H		No	ClinGen TOPMed
CA386436816 rs1361046719	457	N>K		No	ClinGen TOPMed
rs755094723 CA6769458	459	D>V		No	ClinGen ExAC gnomAD
COSM3687933 CA243330219 rs889648907	461	R>H	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA386436722 rs1434037323	462	I>V		No	ClinGen gnomAD
rs1390519594 CA386436654	465	L>I		No	ClinGen gnomAD
rs986144684 CA243330203	469	M>I		No	ClinGen gnomAD
CA6769457 rs751523459	469	M>L		No	ClinGen ExAC gnomAD
rs780319369 CA6769456	470	A>G		No	ClinGen ExAC gnomAD
rs1314791370 CA386436547	470	A>S		No	ClinGen TOPMed
rs201986662 CA6769455	472	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA386436501 rs1424981338	472	I>T		No	ClinGen gnomAD

No associated diseases with Q9ULV4

4 regional properties for Q9ULV4

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	66 - 118	IPR001680-1
repeat	WD40 repeat	119 - 211	IPR001680-2
domain	Domain of unknown function DUF1899	3 - 68	IPR015048
conserved_site	WD40 repeat, conserved site	146 - 160	IPR019775

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side Cell projection, lamellipodium Cell projection, ruffle membrane Cytoplasm, cytoskeleton Cytoplasm, cell cortex Endosome membrane	All isoforms colocalize with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:10828594, PubMed:19651142, PubMed:25074804) Colocalizes with F-actin at the leading edge of lamellipodia Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:10828594, PubMed:19651142, PubMed:25074804) Localizes to endosome membrane tubules/buds (PubMed:30220460)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

11 GO annotations of cellular component

Name	Definition
actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
endosome membrane	The lipid bilayer surrounding an endosome.
flotillin complex	A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.
focal adhesion	A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).
lamellipodium	A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
lateral plasma membrane	The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
ruffle membrane	The portion of the plasma membrane surrounding a ruffle.
sarcolemma	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
sarcomere	The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

2 GO annotations of molecular function

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
small GTPase binding	Binding to a small monomeric GTPase.

23 GO annotations of biological process

Name	Definition
actin filament organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
activation of GTPase activity	Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
endosomal transport	The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
endosome fission	The process by which early and late endosomes undergo budding and fission reactions that separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane.
endosome membrane tubulation	A membrane tubulation process occurring in an endosome membrane.
establishment of protein localization	The directed movement of a protein to a specific location.
membrane fission	A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
negative regulation of epithelial cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
negative regulation of focal adhesion assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
negative regulation of protein kinase activity by regulation of protein phosphorylation	The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.
negative regulation of protein phosphorylation	Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
negative regulation of substrate adhesion-dependent cell spreading	Any process that stops, prevents or reduces the frequency, rate or extent of substrate adhesion-dependent cell spreading.
neural crest cell migration	The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.
phagocytosis	A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive regulation of lamellipodium morphogenesis	Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis.
regulation of epithelial cell migration	Any process that modulates the frequency, rate or extent of epithelial cell migration.
regulation of fibroblast migration	Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
regulation of focal adhesion assembly	Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
regulation of protein phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
regulation of ruffle assembly	Any process that modulates the frequency, rate or extent of ruffle assembly.
regulation of substrate adhesion-dependent cell spreading	Any process that modulates the frequency, rate or extent of substrate adhesion-dependent cell spreading.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q06440	CRN1	Coronin-like protein	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P57737	CORO7	Coronin-7	Homo sapiens (Human)	PR
Q9UQ03	CORO2B	Coronin-2B	Homo sapiens (Human)	PR
Q6QEF8	CORO6	Coronin-6	Homo sapiens (Human)	PR
Q9WUM3	Coro1b	Coronin-1B	Mus musculus (Mouse)	PR
Q920M5	Coro6	Coronin-6	Mus musculus (Mouse)	PR
Q9WUM4	Coro1c	Coronin-1C	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MRRVVRQSKF	RHVFGQAVKN	DQCYDDIRVS	RVTWDSSFCA	VNPRFVAIII	EASGGGAFLV
70	80	90	100	110	120
LPLHKTGRID	KSYPTVCGHT	GPVLDIDWCP	HNDQVIASGS	EDCTVMVWQI	PENGLTLSLT
130	140	150	160	170	180
EPVVILEGHS	KRVGIVAWHP	TARNVLLSAG	CDNAIIIWNV	GTGEALINLD	DMHSDMIYNV
190	200	210	220	230	240
SWNRNGSLIC	TASKDKKVRV	IDPRKQEIVA	EKEKAHEGAR	PMRAIFLADG	NVFTTGFSRM
250	260	270	280	290	300
SERQLALWNP	KNMQEPIALH	EMDTSNGVLL	PFYDPDTSII	YLCGKGDSSI	RYFEITDESP
310	320	330	340	350	360
YVHYLNTFSS	KEPQRGMGYM	PKRGLDVNKC	EIARFFKLHE	RKCEPIIMTV	PRKSDLFQDD
370	380	390	400	410	420
LYPDTAGPEA	ALEAEEWFEG	KNADPILISL	KHGYIPGKNR	DLKVVKKNIL	DSKPTANKKC
430	440	450	460	470
DLISIPKKTT	DTASVQNEAK	LDEILKEIKS	IKDTICNQDE	RISKLEQQMA	KIAA