Q06440
Gene name |
CRN1 (YLR429W, L9576.2) |
Protein name |
Coronin-like protein |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YLR429W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q06440
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q06440-F1 | Predicted | AlphaFoldDB |
16 variants for Q06440
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s12-991056 | 95 | H>Y | No | SGRP | |
| s12-991113 | 114 | N>D | No | SGRP | |
| s12-991131 | 120 | H>Y | No | SGRP | |
| s12-991365 | 198 | A>T | No | SGRP | |
| s12-991953 | 394 | G>S | No | SGRP | |
| s12-991999 | 409 | P>Q | No | SGRP | |
| s12-992241 | 490 | V>I | No | SGRP | |
| s12-992304 | 511 | A>T | No | SGRP | |
| s12-992329 | 519 | V>A | No | SGRP | |
| s12-992328 | 519 | V>I | No | SGRP | |
| s12-992332 | 520 | T>S | No | SGRP | |
| s12-992445 | 558 | E>K | No | SGRP | |
| s12-992538 | 589 | A>T | No | SGRP | |
| s12-992569 | 599 | R>K | No | SGRP | |
| s12-992598 | 609 | K>Q | No | SGRP | |
| s12-992659 | 629 | T>M | No | SGRP |
No associated diseases with Q06440
1 regional properties for Q06440
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glycosyltransferase 2-like | 242 - 441 | IPR001173 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cortical patch | An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| Arp2/3 complex binding | Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). |
| microtubule binding | Binding to a microtubule, a filament composed of tubulin monomers. |
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cortical patch localization | Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells. |
| actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. |
| microtubule-based process | Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. |
| negative regulation of Arp2/3 complex-mediated actin nucleation | Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins. |
| positive regulation of Arp2/3 complex-mediated actin nucleation | Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9ULV4 | CORO1C | Coronin-1C | Homo sapiens (Human) | PR |
| Q9UQ03 | CORO2B | Coronin-2B | Homo sapiens (Human) | PR |
| Q6QEF8 | CORO6 | Coronin-6 | Homo sapiens (Human) | PR |
| Q9WUM3 | Coro1b | Coronin-1B | Mus musculus (Mouse) | PR |
| Q9WUM4 | Coro1c | Coronin-1C | Mus musculus (Mouse) | PR |
| Q920M5 | Coro6 | Coronin-6 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGKFVRASK | YRHVFGQAAK | KELQYEKLKV | TNNAWDSNLL | KTNGKFIAVN | WNASGGGAFA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VIPIEEVGKA | PDQVPLFRGH | TAQVLDTDFD | PFNDHRIASG | SDDSKIGIWD | IPENYKFHDH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VDEDGEPIDI | KPVKFLTGHA | RKVGHVLYHP | VAENVLASSS | GDYTVKLWNV | ETGKDMITLK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HPDMVTSMSF | SYDGNYLATV | ARDKKLRVWN | IREEKIVSEG | PAHTGAKNQR | VVWLGNSDRL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ATTGFSKLSD | RQIGIWDAFN | IEKGDLGGFY | TVDQSSGILM | PFYDEGNKIL | YLVGKGDGNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RYYEFQNDEL | FELSEFQSTE | AQRGFAVAPK | RMVNVKENEV | LKGFKTVVDQ | RIEPVSFFVP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RRSEEFQEDI | YPDAPSNKPA | LTAEEWFSGK | SVEGPILVSM | RSIYDGSAPS | FHEAKRPQQP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TTQETALEEK | KEQPKVEKPI | SESEKEVKQE | APKSPSPLKS | ASSSSTINHV | LKEDNSINKL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LKKSSDIDQV | NNAEDPSRDT | SGWEEADDEP | APIKIETPVT | PTETKKDRTP | KVEPSKELKP |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EPVSIATDRK | QEQSLPQEEK | SSEKTKSPEQ | EKSATPPSSI | TAAKTAITAS | SKEEPSAART |
| 610 | 620 | 630 | 640 | 650 | |
| SPKSLGLKKS | VEKLSTLVLQ | LEDVVDKLTK | ANLDKDERLL | KLEQKIGELS | K |