AiPD: Autoinhibited Protein Database

Gene name	Coro7
Protein name	Coronin-7
Names	Crn7, 70 kDa WD repeat tumor rejection antigen homolog
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:78885
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

839-917 (Predicted disordered autoinhibitory region) PR

839-917 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9D2V7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs47868465	2	S>N	No	EVA
rs3389358625	22	W>*	No	EVA
rs3389399152	25	D>V	No	EVA
rs3389348202	32	P>L	No	EVA
rs235497919	61	E>K	No	EVA
rs3389348154	68	R>S	No	EVA
rs3389313910	121	V>S	No	EVA
rs3389406974	122	L>R	No	EVA
rs3389358645	123	G>C	No	EVA
rs3389313893	132	L>M	No	EVA
rs3389348172	140	G>E*	No	EVA
rs3389395110	143	V>G	No	EVA
rs3389395500	148	K>R	No	EVA
rs3389348152	165	E>*	No	EVA
rs3413134963	168	K>Q	No	EVA
rs3389390892	176	W>L	No	EVA
rs3389348126	180	G>E	No	EVA
rs3389390874	205	Q>*	No	EVA
rs3412902596	208	Q>R	No	EVA
rs3389395107	229	S>P	No	EVA
rs3389388483	233	N>D	No	EVA
rs3389395134	248	F>I	No	EVA
rs3389388463	259	T>I	No	EVA
rs3389399150	260	S>Y	No	EVA
rs3389348128	288	Y>C	No	EVA
rs3389358529	298	S>I	No	EVA
rs3389390854	334	S>G	No	EVA
rs3389395163	340	P>L	No	EVA
rs3389399185	342	S>G	No	EVA
rs51648975	350	V>I	No	EVA
rs3389348216	373	W>*	No	EVA
rs3389391131	384	S>G	No	EVA
rs264509048	410	V>A	No	EVA
rs3389412649	477	L>F	No	EVA
rs3389367180	477	L>P	No	EVA
rs3389399226	521	V>M	No	EVA
rs3389395568	531	P>L	No	EVA
rs46299316	542	T>A	No	EVA
rs3389398144	549	W>*	No	EVA
rs3389388466	658	V>G	No	EVA
rs3389406887	677	E>D	No	EVA
rs261425482	685	V>I	No	EVA
rs3389377190	686	W>*	No	EVA
rs223399162	701	R>Q	No	EVA
rs3389388448	729	S>L	No	EVA
rs3389391136	781	L>F	No	EVA
rs3389395124	792	V>M	No	EVA
rs3412564235	817	K>R	No	EVA
rs3406270812	849	P>T	No	EVA
rs52050677	850	R>Q	No	EVA
rs13473982	851	L>V	No	EVA
rs3389399159	857	P>S	No	EVA
rs3389367165	859	M>I	No	EVA
rs3389412650	860	T>S	No	EVA
rs238246985	867	R>H	No	EVA
rs3389398145	874	A>V	No	EVA
rs3389406893	888	Q>L	No	EVA
rs3389391132	892	E>D	No	EVA
rs3389377251	903	N>D	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	66 - 108	IPR001680-1
repeat	WD40 repeat	115 - 154	IPR001680-2
repeat	WD40 repeat	157 - 205	IPR001680-3
repeat	WD40 repeat	531 - 570	IPR001680-4
repeat	WD40 repeat	580 - 662	IPR001680-5
domain	Domain of unknown function DUF1899	3 - 64	IPR015048-1
domain	Domain of unknown function DUF1899	463 - 529	IPR015048-2
conserved_site	WD40 repeat, conserved site	607 - 621	IPR019775
repeat	G-protein beta WD-40 repeat	93 - 107	IPR020472-1
repeat	G-protein beta WD-40 repeat	141 - 155	IPR020472-2
repeat	G-protein beta WD-40 repeat	607 - 621	IPR020472-3

		Description
EC Number
Subcellular Localization	Golgi apparatus membrane Golgi apparatus, trans-Golgi network Cytoplasmic vesicle Cytoplasm, cytosol	Predominantly cytosolic Detected on vesicle-like cytoplasmic structures and on the cis-Golgi Not associated with actin filaments
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
trans-Golgi network	The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

Name	Definition
actin binding	Binding to monomeric or multimeric forms of actin, including actin filaments.
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.

Name	Definition
actin filament organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
actin filament polymerization	Assembly of actin filaments by the addition of actin monomers to a filament.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
establishment of cell polarity	The specification and formation of anisotropic intracellular organization or cell growth patterns.
Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
Golgi to endosome transport	The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
positive regulation of hippo signaling	Any process that activates or increases the frequency, rate or extent of hippo signaling.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0V8F1	CORO7	Coronin-7	Bos taurus (Bovine)	PR
P57737	CORO7	Coronin-7	Homo sapiens (Human)	PR
Q9WUM3	Coro1b	Coronin-1B	Mus musculus (Mouse)	PR
Q9WUM4	Coro1c	Coronin-1C	Mus musculus (Mouse)	PR
Q920M5	Coro6	Coronin-6	Mus musculus (Mouse)	PR