Q9VYG2
PR
Gene name |
Bap60 (CG4303) |
Protein name |
Brahma-associated protein of 60 kDa |
Names |
BRM-associated protein 60 |
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG4303 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9VYG2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9VYG2-F1 | Predicted | AlphaFoldDB |
No variants for Q9VYG2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q9VYG2 | |||||
No associated diseases with Q9VYG2
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| brahma complex | A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the Drosophila brm (brahma) or mammalian SMARCA2/BAF190B/BRM gene, or an ortholog thereof. |
| euchromatin | A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation. |
| nBAF complex | A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| npBAF complex | A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| SWI/SNF complex | A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| myosin binding | Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. |
| protein domain specific binding | Binding to a specific domain of a protein. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| transcription coregulator activity | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
| transcription factor binding | Binding to a transcription factor, a protein required to initiate or regulate transcription. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of neuroblast proliferation | Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| positive regulation of gene expression | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| positive regulation of heterochromatin assembly | Any process that activates or increases the frequency, rate or extent of heterochromatin formation. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBN1 | SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Bos taurus (Bovine) | PR |
| E1BJD1 | SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Bos taurus (Bovine) | PR |
| Q6STE5 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 | Homo sapiens (Human) | PR |
| Q92925 | SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Homo sapiens (Human) | PR |
| Q96GM5 | SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Homo sapiens (Human) | PR |
| Q61466 | Smarcd1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Mus musculus (Mouse) | PR |
| Q6P9Z1 | Smarcd3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 | Mus musculus (Mouse) | PR |
| Q99JR8 | Smarcd2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Mus musculus (Mouse) | PR |
| O54772 | Smarcd2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQRFAPGQA | PVQSRYQPPP | PAPGMRPYPP | PGASFPPRGF | PLHPNTTQPV | PGTANVAGVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GVPGVPGVPG | PSLLQRAAQQ | PGFQSSLRGT | GAGGGGVGSG | GGSKRSNESR | SLGGGGSKSD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FATAKKKKKL | AEKILPQKVR | DLVPESQAYM | DLLTFERKLD | ATIMRKRLDI | QEALKRPMKQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRKLRIFISN | TFYPSKEPTN | DGEEGAVASW | ELRVEGRLLE | DGKGDPNTKI | KRKFSSFFKS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LVIELDKELY | GPDNHLVEWH | RTHTTQETDG | FQVKRPGDRN | VRCTILLLLD | YQPLQFKLDP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLARLLGVHT | QTRPVIISAL | WQYIKTHKLQ | DAHEREYINC | DKYLEQIFSC | QRMKFAEIPQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RLNPLLHPPD | PIVINHFIES | GAENKQTACY | DIDVEVDDTL | KNQMNSFLMS | TASQQEIQGL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DTKIHETVDT | INQMKTNREF | FLSFAKDPQM | FIHRWIISET | RDLKLMTDVA | GNPEEERRAE |
| 490 | 500 | 510 | |||
| FYYQPWTHEA | VSRYFFTKVN | QKRAELEQAL | GIRNG |