Q2TBN1
Gene name |
SMARCD1 (BAF60A) |
Protein name |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 |
Names |
60 kDa BRG-1/Brm-associated factor subunit A, BRG1-associated factor 60A, BAF60A, SWI/SNF complex 60 kDa subunit |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:533232 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q2TBN1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q2TBN1-F1 | Predicted | AlphaFoldDB |
No variants for Q2TBN1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q2TBN1 | |||||
No associated diseases with Q2TBN1
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nBAF complex | A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. |
| npBAF complex | A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. |
| SWI/SNF complex | A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| E1BJD1 | SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Bos taurus (Bovine) | PR |
| Q9VYG2 | Bap60 | Brahma-associated protein of 60 kDa | Drosophila melanogaster (Fruit fly) | PR |
| Q6STE5 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 | Homo sapiens (Human) | PR |
| Q92925 | SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Homo sapiens (Human) | PR |
| Q96GM5 | SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Homo sapiens (Human) | PR |
| Q99JR8 | Smarcd2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Mus musculus (Mouse) | PR |
| Q6P9Z1 | Smarcd3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 | Mus musculus (Mouse) | PR |
| Q61466 | Smarcd1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Mus musculus (Mouse) | PR |
| O54772 | Smarcd2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARAGFQSV | APSGGAGASG | GAGAAAALGP | GGTPGPPVRM | GPAPGQGLYR | SPMPGAAYPR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGMLPGSRMT | PQGPSMGPPG | YGGNPSVRPG | LAQSGMDQSL | KRPAPQQIKQ | VQQQAVQNRN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HNAKKKKMAD | KILPQRIREL | VPESQDYMDL | LAFERKLDQT | IMRKRLDIQE | ALKRPIKQKR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLRIFISNTF | NPAKSDAEDG | EGTVASWELR | VEGRLLEDSA | LSKYDATKQK | RKFSSFFKSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIELDKDLYG | PDNHLVEWHR | TATTQETDGF | QVKRPGDVNV | RCTVLLMLDY | QPPQFKLDPR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LARLLGIHTQ | TRPVIIQALW | QYIKTHKLQD | PHEREFVICD | KYLQQIFESQ | RMKFSEIPQR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LHALLMPPEP | IIINHVISVD | PNDQKKTACY | DIDEEVDDTL | KTQMNSFLLS | TASQQEIATL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DNKIHETIET | INQLKTQREF | MLSFARDPQG | FINDWLQSQC | RDLKVMTDVV | GNSEEERRAE |
| 490 | 500 | 510 | |||
| FYFQPWAQEA | VCRYFYSKVQ | QRRQELEQAL | GIRNT |