O54772
Gene name |
Smarcd2 (Baf60b) |
Protein name |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 |
Names |
60 kDa BRG-1/Brm-associated factor subunit B, BRG1-associated factor 60B, BAF60B |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:83833 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O54772
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O54772-F1 | Predicted | AlphaFoldDB |
No variants for O54772
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O54772 | |||||
No associated diseases with O54772
No regional properties for O54772
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for O54772 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| SWI/SNF complex | A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transcription coregulator activity | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| nucleosome disassembly | The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2TBN1 | SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Bos taurus (Bovine) | PR |
| E1BJD1 | SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Bos taurus (Bovine) | PR |
| Q9VYG2 | Bap60 | Brahma-associated protein of 60 kDa | Drosophila melanogaster (Fruit fly) | PR |
| Q6STE5 | SMARCD3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 | Homo sapiens (Human) | PR |
| Q96GM5 | SMARCD1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Homo sapiens (Human) | PR |
| Q92925 | SMARCD2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Homo sapiens (Human) | PR |
| Q61466 | Smarcd1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 | Mus musculus (Mouse) | PR |
| Q6P9Z1 | Smarcd3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 | Mus musculus (Mouse) | PR |
| Q99JR8 | Smarcd2 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGRGAGGFP | LPPLSPGGGA | VAAALGAPPP | PAGPGMLPNP | ALRGPGPSGG | MGVPGAAAFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PMGPAGPAAQ | YQRPGMSPGS | RMPMAGLQVG | PPAGSPFGTA | APLRPGMPPT | MMDPFRKRLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPQAQPPMPA | QRRGLKRRKM | ADKVLPQRIR | ELVPESQAYM | DLLAFERKLD | QTIARKRMEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QEAIKKPLTQ | KRKLRIYISN | TFSPSKADGD | NSGTAGTPGG | TPAADKVASW | ELRVEGKLLD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DPSKQKRKFS | SFFKSLVIEL | DKELYGPDNH | LVEWHRMPTT | QETDGFQVKR | PGDLNVKCTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LLMLDHQPPQ | YKLDPRLARL | LGVHTQTRAA | IMQALWLYIK | HNQLQDGHER | EYINCNRYFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QIFSCGRLRF | SEIPMKLAGL | LQHPDPIVIN | HVISVDPNDQ | KKTACYDIDV | EVDDPLKAQM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SNFLASTTNQ | QEIASLDVKI | HETIESINQL | KTQRDFMLSF | STEPQDFIQE | WLRSQRRDLK |
| 490 | 500 | 510 | 520 | 530 | |
| IITDVIGNPE | EERRAAFYHQ | PWAQEAVGRH | IFAKVQQRRQ | ELEQVLGIRL | T |