AiPD: Autoinhibited Protein Database

Gene name	CESA7
Protein name	Cellulose synthase A catalytic subunit 7 [UDP-forming]
Names	AtCesA7, Protein FRAGILE FIBER 5, Protein IRREGULAR XYLEM 3, AtIRX3
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G17420
EC number	2.4.1.12: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

47-256 (Predicted disordered autoinhibitory region) PR

47-256 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1WEO	NMR	-	A	26-105	PDB
AF-Q9SWW6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_5_5741356_C_G	18	V>L	No	1000Genomes
tmp_5_5740837_T_C	57	N>D	No	1000Genomes
ENSVATH10807292	96	E>G	No	1000Genomes
ENSVATH03068495	117	Q>H	No	1000Genomes
ENSVATH03068494	118	D>E	No	1000Genomes
ENSVATH03068493	120	H>Q	No	1000Genomes
ENSVATH06982073	124	A>P	No	1000Genomes
ENSVATH03068492	149	V>I	No	1000Genomes
ENSVATH10807291	159	P>L	No	1000Genomes
tmp_5_5740395_C_T	161	G>E	No	1000Genomes
tmp_5_5740383_C_T	165	G>D	No	1000Genomes
ENSVATH14063775	172	H>L	No	1000Genomes
ENSVATH10807289	190	R>P	No	1000Genomes
ENSVATH06982064	193	M>T	No	1000Genomes
ENSVATH14063682	250	V>I	No	1000Genomes
ENSVATH14063681	253	R>Q	No	1000Genomes
tmp_5_5739738_A_G	264	L>P	No	1000Genomes
ENSVATH06982051	431	A>T	No	1000Genomes
ENSVATH14063678	434	A>G	No	1000Genomes
tmp_5_5738941_A_C	474	F>V	No	1000Genomes
tmp_5_5738932_C_T	477	E>K	No	1000Genomes
ENSVATH06982046	634	K>N	No	1000Genomes
tmp_5_5738304_T_G	634	K>T	No	1000Genomes
ENSVATH10807227	657	H>Q	No	1000Genomes
ENSVATH00627323	667	T>K	No	1000Genomes
tmp_5_5737979_C_G	711	E>Q	No	1000Genomes
tmp_5_5737779_C_A	747	R>S	No	1000Genomes
tmp_5_5737187_G_A	918	A>V	No	1000Genomes
tmp_5_5737125_C_T	939	V>I	No	1000Genomes
tmp_5_5737038_T_C	968	I>V	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	37 - 83	IPR001841
domain	Cellulose synthase, RING-type zinc finger	27 - 103	IPR027934

		Description
EC Number	2.4.1.12	Hexosyltransferases
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cellulose synthase complex	A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall.
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
cellulose synthase (UDP-forming) activity	Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1).
cellulose synthase activity	Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1).
metal ion binding	Binding to a metal ion.

Name	Definition
cellulose biosynthetic process	The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
plant-type cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana.
plant-type primary cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana.
plant-type secondary cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana.
rhamnogalacturonan I side chain metabolic process	The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q69P51	CESA9	Cellulose synthase A catalytic subunit 9 [UDP-forming]	Oryza sativa subsp japonica (Rice)	PR
Q9SJ22	CESA9	Probable cellulose synthase A catalytic subunit 9 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
O49323	CSLD1	Cellulose synthase-like protein D1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LPK5	CESA8	Cellulose synthase A catalytic subunit 8 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
O48947	CESA2	Cellulose synthase A catalytic subunit 2 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94JQ6	CESA6	Cellulose synthase A catalytic subunit 6 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR