Q8LPK5

PR
Gene name
CESA8 (IRX1, LEW2, At4g18780, F28A21.190)
Protein name
Cellulose synthase A catalytic subunit 8 [UDP-forming]
Names
AtCesA8, Protein IRREGULAR XYLEM 1, AtIRX1, Protein LEAF WILTING 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G18780
EC number
2.4.1.12: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-191 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8LPK5

Entry ID Method Resolution Chain Position Source
AF-Q8LPK5-F1 Predicted AlphaFoldDB

54 variants for Q8LPK5

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH11988108 16 I>V No 1000Genomes
ENSVATH00520746 18 V>A No 1000Genomes
ENSVATH00520745 24 F>V No 1000Genomes
ENSVATH14249320 29 H>Q No 1000Genomes
tmp_4_10316402_T_C 76 I>V No 1000Genomes
ENSVATH11988071 80 Q>K No 1000Genomes
tmp_4_10316380_T_G 83 N>T No 1000Genomes
ENSVATH00520743 85 S>P No 1000Genomes
tmp_4_10316371_T_C 86 Q>R No 1000Genomes
ENSVATH06718821 139 T>I No 1000Genomes
tmp_4_10316030_C_A 141 A>S No 1000Genomes
ENSVATH00520738 143 Q>H No 1000Genomes
ENSVATH02876421 144 H>Q No 1000Genomes
ENSVATH00520737 145 E>D No 1000Genomes
ENSVATH00520736 148 I>V No 1000Genomes
ENSVATH00520734 157 T>M No 1000Genomes
ENSVATH14249318 158 P>S No 1000Genomes
tmp_4_10315749_C_G 207 D>H No 1000Genomes
tmp_4_10315647_C_T 241 E>K No 1000Genomes
ENSVATH02876404 249 A>V No 1000Genomes
tmp_4_10315504_G_A 258 S>L No 1000Genomes
ENSVATH06718814 290 L>F No 1000Genomes
tmp_4_10315406_C_T 291 D>N No 1000Genomes
ENSVATH11987979 330 K>N No 1000Genomes
ENSVATH11987913 403 T>P No 1000Genomes
tmp_4_10314850_C_T 420 R>H No 1000Genomes
tmp_4_10314835_T_C 425 N>S No 1000Genomes
ENSVATH02876367 492 V>A No 1000Genomes
ENSVATH02876368 492 V>I No 1000Genomes
tmp_4_10314555_T_G 496 D>A No 1000Genomes
ENSVATH11987905 533 I>V No 1000Genomes
ENSVATH11987864 563 P>L No 1000Genomes
ENSVATH06718795 579 P>H No 1000Genomes
ENSVATH00520700 583 S>A No 1000Genomes
ENSVATH06718794 589 A>E No 1000Genomes
tmp_4_10314150_G_T 604 L>I No 1000Genomes
tmp_4_10314145_G_T 605 D>E No 1000Genomes
ENSVATH11987862 606 N>K No 1000Genomes
ENSVATH06718790 613 S>P No 1000Genomes
ENSVATH06718788 637 M>V No 1000Genomes
ENSVATH14249317 641 G>D No 1000Genomes
ENSVATH11987861 644 D>E No 1000Genomes
tmp_4_10314011_G_A 650 T>M No 1000Genomes
tmp_4_10314006_T_C 652 I>V No 1000Genomes
tmp_4_10313766_A_T 707 F>L No 1000Genomes
ENSVATH06718782 713 I>M No 1000Genomes
ENSVATH06718776 740 L>F No 1000Genomes
ENSVATH11987855 743 G>S No 1000Genomes
tmp_4_10313414_A_G 797 M>T No 1000Genomes
ENSVATH14249315 850 M>I No 1000Genomes
tmp_4_10313213_G_C 864 T>S No 1000Genomes
tmp_4_10313127_A_C 893 L>V No 1000Genomes
tmp_4_10313061_A_T 915 F>I No 1000Genomes
tmp_4_10312919_A_C 962 V>G No 1000Genomes

No associated diseases with Q8LPK5

1 regional properties for Q8LPK5

Type Name Position InterPro Accession
domain Cellulose synthase, RING-type zinc finger 4 - 59 IPR027934

Functions

Description
EC Number 2.4.1.12 Hexosyltransferases
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
cellulose synthase (UDP-forming) activity Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1).
cellulose synthase activity Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1).
metal ion binding Binding to a metal ion.

8 GO annotations of biological process

Name Definition
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.
plant-type primary cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana.
plant-type secondary cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana.
response to osmotic stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
response to water deprivation Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5JN63 CESA4 Cellulose synthase A catalytic subunit 4 [UDP-forming] Oryza sativa subsp japonica (Rice) PR
Q9SJ22 CESA9 Probable cellulose synthase A catalytic subunit 9 [UDP-forming] Arabidopsis thaliana (Mouse-ear cress) PR
O49323 CSLD1 Cellulose synthase-like protein D1 Arabidopsis thaliana (Mouse-ear cress) PR
O48947 CESA2 Cellulose synthase A catalytic subunit 2 [UDP-forming] Arabidopsis thaliana (Mouse-ear cress) PR
Q9SWW6 CESA7 Cellulose synthase A catalytic subunit 7 [UDP-forming] Arabidopsis thaliana (Mouse-ear cress) PR
Q94JQ6 CESA6 Cellulose synthase A catalytic subunit 6 [UDP-forming] Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MMESRSPICN TCGEEIGVKS NGEFFVACHE CSFPICKACL EYEFKEGRRI CLRCGNPYDE
70 80 90 100 110 120
NVFDDVETKT SKTQSIVPTQ TNNTSQDSGI HARHISTVST IDSELNDEYG NPIWKNRVES
130 140 150 160 170 180
WKDKKDKKSK KKKKDPKATK AEQHEAQIPT QQHMEDTPPN TESGATDVLS VVIPIPRTKI
190 200 210 220 230 240
TSYRIVIIMR LIILALFFNY RITHPVDSAY GLWLTSVICE IWFAVSWVLD QFPKWSPINR
250 260 270 280 290 300
ETYIDRLSAR FEREGEQSQL AAVDFFVSTV DPLKEPPLIT ANTVLSILAL DYPVDKVSCY
310 320 330 340 350 360
VSDDGAAMLS FESLVETADF ARKWVPFCKK YSIEPRAPEF YFSLKIDYLR DKVQPSFVKE
370 380 390 400 410 420
RRAMKRDYEE FKIRMNALVA KAQKTPEEGW TMQDGTSWPG NNTRDHPGMI QVFLGYSGAR
430 440 450 460 470 480
DIEGNELPRL VYVSREKRPG YQHHKKAGAE NALVRVSAVL TNAPFILNLD CDHYVNNSKA
490 500 510 520 530 540
VREAMCFLMD PVVGQDVCFV QFPQRFDGID KSDRYANRNI VFFDVNMRGL DGIQGPVYVG
550 560 570 580 590 600
TGTVFRRQAL YGYSPPSKPR ILPQSSSSSC CCLTKKKQPQ DPSEIYKDAK REELDAAIFN
610 620 630 640 650 660
LGDLDNYDEY DRSMLISQTS FEKTFGLSTV FIESTLMENG GVPDSVNPST LIKEAIHVIS
670 680 690 700 710 720
CGYEEKTEWG KEIGWIYGSI TEDILTGFKM HCRGWRSIYC MPLRPAFKGS APINLSDRLH
730 740 750 760 770 780
QVLRWALGSV EIFLSRHCPL WYGCSGGRLK LLQRLAYINT IVYPFTSLPL VAYCTLPAIC
790 800 810 820 830 840
LLTGKFIIPT LSNLASMLFL GLFISIILTS VLELRWSGVS IEDLWRNEQF WVIGGVSAHL
850 860 870 880 890 900
FAVFQGFLKM LAGLDTNFTV TSKTADDLEF GELYIVKWTT LLIPPTSLLI INLVGVVAGF
910 920 930 940 950 960
SDALNKGYEA WGPLFGKVFF AFWVILHLYP FLKGLMGRQN RTPTIVILWS ILLASVFSLV
970 980
WVRINPFVSK TDTTSLSLNC LLIDC