AiPD: Autoinhibited Protein Database

Gene name	CESA2 (ATHA, At4g39350, T22F8.250)
Protein name	Cellulose synthase A catalytic subunit 2 [UDP-forming]
Names	AtCesA2, Ath-A
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G39350
EC number	2.4.1.12: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

52-168 (Predicted disordered autoinhibitory region) PR

52-168 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O48947-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH02979686	51	S>N	No	1000Genomes
ENSVATH14360809	53	E>V	No	1000Genomes
tmp_4_18297818_A_T	78	N>I	No	1000Genomes
ENSVATH02979688	111	E>D	No	1000Genomes
tmp_4_18298003_G_A	140	D>N	No	1000Genomes
ENSVATH14360810	158	A>G	No	1000Genomes
tmp_4_18298152_C_A	162	S>Y	No	1000Genomes
tmp_4_18298173_T_G	169	V>G	No	1000Genomes
ENSVATH14360812	225	E>K	No	1000Genomes
ENSVATH00559637	237	N>D	No	1000Genomes
ENSVATH06853178	238	G>V	No	1000Genomes
ENSVATH00559638	241	S>F	No	1000Genomes
tmp_4_18298674_A_G	268	I>V	No	1000Genomes
tmp_4_18299764_T_G	520	L>V	No	1000Genomes
ENSVATH12501226	611	R>H	No	1000Genomes
tmp_4_18300347_C_G	654	P>A	No	1000Genomes
ENSVATH12501228	676	S>T	No	1000Genomes
ENSVATH14360850	687	T>A	No	1000Genomes
ENSVATH00559649	688	K>I	No	1000Genomes
ENSVATH00559649	688	K>T	No	1000Genomes
ENSVATH06853198	692	K>E	No	1000Genomes
ENSVATH12501229	696	A>V	No	1000Genomes
ENSVATH00559650	698	E>Q	No	1000Genomes
ENSVATH00559651	702	E>K	No	1000Genomes
ENSVATH00559652	706	V>I	No	1000Genomes
tmp_4_18300612_T_C	715	S>P	No	1000Genomes
ENSVATH06853199	737	V>I	No	1000Genomes
tmp_4_18300690_G_T	741	G>C	No	1000Genomes
ENSVATH12501255	872	V>I	No	1000Genomes
tmp_4_18301740_G_T	1035	M>I	No	1000Genomes
ENSVATH00559655	1083	G>E	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	39 - 85	IPR001841
domain	Cellulose synthase, RING-type zinc finger	30 - 105	IPR027934

		Description
EC Number	2.4.1.12	Hexosyltransferases
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
cellulose synthase (UDP-forming) activity	Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1).
cellulose synthase activity	Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1).
metal ion binding	Binding to a metal ion.

Name	Definition
cell wall organization	A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
cellulose biosynthetic process	The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
plant-type primary cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q69V23	CESA3	Probable cellulose synthase A catalytic subunit 3 [UDP-forming]	Oryza sativa subsp japonica (Rice)	PR
Q6YVM4	CESA6	Probable cellulose synthase A catalytic subunit 6 [UDP-forming]	Oryza sativa subsp japonica (Rice)	PR
Q851L8	CESA5	Probable cellulose synthase A catalytic subunit 5 [UDP-forming]	Oryza sativa subsp japonica (Rice)	PR
Q94JQ6	CESA6	Cellulose synthase A catalytic subunit 6 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SJ22	CESA9	Probable cellulose synthase A catalytic subunit 9 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
O49323	CSLD1	Cellulose synthase-like protein D1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LPK5	CESA8	Cellulose synthase A catalytic subunit 8 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SWW6	CESA7	Cellulose synthase A catalytic subunit 7 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR