AiPD: Autoinhibited Protein Database

Gene name	CESA6 (IXR2, PRC1, QUI, At5g64740, MVP7.7)
Protein name	Cellulose synthase A catalytic subunit 6 [UDP-forming]
Names	AtCesA6, AraxCelA, Isoxaben-resistant protein 2, Protein PROCUSTE 1, Protein QUILL
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT5G64740
EC number	2.4.1.12: Hexosyltransferases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

53-127 (Predicted disordered autoinhibitory region) PR

53-127 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q94JQ6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH12931050	38	T>I	No	1000Genomes
ENSVATH08585979	78	N>I	No	1000Genomes
tmp_5_25882328_G_C	98	E>Q	No	1000Genomes
ENSVATH03475215	118	N>T	No	1000Genomes
ENSVATH12931054	136	S>T	No	1000Genomes
tmp_5_25882681_T_C	188	S>P	No	1000Genomes
tmp_5_25882832_A_C	238	E>A	No	1000Genomes
tmp_5_25882865_C_T	249	A>V	No	1000Genomes
ENSVATH14648322	355	V>M	No	1000Genomes
ENSVATH12931115	459	D>Y	No	1000Genomes
ENSVATH12931117	589	I>F	No	1000Genomes
tmp_5_25884612_G_T	621	G>C	No	1000Genomes
ENSVATH00751641	653	G>A	No	1000Genomes
tmp_5_25884796_C_T	682	A>V	No	1000Genomes
ENSVATH07479430	711	N>I	No	1000Genomes
ENSVATH03475251	712	V>I	No	1000Genomes
ENSVATH14648326	738	R>C	No	1000Genomes
ENSVATH14648327	739	M>V	No	1000Genomes
ENSVATH12931155	906	S>L	No	1000Genomes
tmp_5_25885803_A_G	909	I>V	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Zinc finger, RING-type	39 - 85	IPR001841
domain	Cellulose synthase, RING-type zinc finger	30 - 105	IPR027934

		Description
EC Number	2.4.1.12	Hexosyltransferases
Subcellular Localization	Cell membrane ; Multi-pass membrane protein	Colocalizes with CSI1 in a dynamic way
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cellulose synthase complex	A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
cellulose synthase (UDP-forming) activity	Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1).
cellulose synthase activity	Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1).
metal ion binding	Binding to a metal ion.

Name	Definition
cell wall organization	A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
cellulose biosynthetic process	The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.
cortical microtubule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.
multidimensional cell growth	The process in which a cell irreversibly increases in size in two or three
plant-type primary cell wall biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q69V23	CESA3	Probable cellulose synthase A catalytic subunit 3 [UDP-forming]	Oryza sativa subsp japonica (Rice)	PR
Q6YVM4	CESA6	Probable cellulose synthase A catalytic subunit 6 [UDP-forming]	Oryza sativa subsp japonica (Rice)	PR
Q851L8	CESA5	Probable cellulose synthase A catalytic subunit 5 [UDP-forming]	Oryza sativa subsp japonica (Rice)	PR
O48947	CESA2	Cellulose synthase A catalytic subunit 2 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SJ22	CESA9	Probable cellulose synthase A catalytic subunit 9 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
O49323	CSLD1	Cellulose synthase-like protein D1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LPK5	CESA8	Cellulose synthase A catalytic subunit 8 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SWW6	CESA7	Cellulose synthase A catalytic subunit 7 [UDP-forming]	Arabidopsis thaliana (Mouse-ear cress)	PR