Q9SKX2

SS
Gene name
PME16 (ARATH16, At2g43050, MFL8.9)
Protein name
Probable pectinesterase/pectinesterase inhibitor 16
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G43050
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

41-172 (PMEI region) SS

Target domain

213-502 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9SKX2

Entry ID Method Resolution Chain Position Source
AF-Q9SKX2-F1 Predicted AlphaFoldDB

52 variants for Q9SKX2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05707915 5 S>P No 1000Genomes
tmp_2_17902551_C_G 15 T>R No 1000Genomes
ENSVATH00272280 17 M>T No 1000Genomes
ENSVATH05707916 27 L>V No 1000Genomes
ENSVATH00272281 31 N>T No 1000Genomes
ENSVATH05707917 36 I>V No 1000Genomes
tmp_2_17902632_C_A 42 S>Y No 1000Genomes
tmp_2_17902639_C_G 44 F>L No 1000Genomes
ENSVATH01982644 53 S>T No 1000Genomes
ENSVATH01982645 58 T>P No 1000Genomes
ENSVATH00272283 65 T>A No 1000Genomes
ENSVATH01982646 71 N>D No 1000Genomes
tmp_2_17902745_G_A 80 A>T No 1000Genomes
tmp_2_17902767_A_G 87 H>R No 1000Genomes
ENSVATH00272284 96 D>N No 1000Genomes
tmp_2_17902826_G_T 107 D>Y No 1000Genomes
ENSVATH05707920 110 D>N No 1000Genomes
tmp_2_17902838_A_G 111 M>V No 1000Genomes
tmp_2_17902863_A_G 119 N>S No 1000Genomes
ENSVATH05707921 132 L>I No 1000Genomes
ENSVATH05707922 150 K>N No 1000Genomes
ENSVATH05707923 156 D>G No 1000Genomes
ENSVATH07916572 159 A>T No 1000Genomes
ENSVATH01982647 166 L>F No 1000Genomes
tmp_2_17903006_A_G 167 T>A No 1000Genomes
ENSVATH01982648 186 K>E No 1000Genomes
ENSVATH05707928 199 Q>H No 1000Genomes
ENSVATH05707927 199 Q>L No 1000Genomes
ENSVATH01982651 200 R>G No 1000Genomes
ENSVATH05707929 206 P>T No 1000Genomes
ENSVATH01982653 211 N>D No 1000Genomes
ENSVATH01982654 211 N>K No 1000Genomes
ENSVATH01982654 211 N>K No 1000Genomes
ENSVATH01982655 218 P>A No 1000Genomes
tmp_2_17903160_C_T 218 P>L No 1000Genomes
ENSVATH00272286 228 G>R No 1000Genomes
ENSVATH05707930 229 E>D No 1000Genomes
tmp_2_17903264_C_T 253 H>Y No 1000Genomes
ENSVATH13623671 280 S>N No 1000Genomes
ENSVATH00272289 312 N>S No 1000Genomes
ENSVATH05707933 333 H>Y No 1000Genomes
ENSVATH00272291 336 S>A No 1000Genomes
ENSVATH00272293 382 K>I No 1000Genomes
tmp_2_17903770_C_T 385 P>S No 1000Genomes
tmp_2_17903785_T_A 390 F>I No 1000Genomes
ENSVATH00272295 406 A>T No 1000Genomes
tmp_2_17903976_C_G 453 F>L No 1000Genomes
ENSVATH05707936 483 P>S No 1000Genomes
tmp_2_17904076_G_A 487 V>M No 1000Genomes
ENSVATH05707938 497 S>N No 1000Genomes
ENSVATH05707939 503 I>K No 1000Genomes
tmp_2_17904145_G_A 510 V>I No 1000Genomes

No associated diseases with Q9SKX2

3 regional properties for Q9SKX2

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 213 - 502 IPR000070
domain Pectinesterase inhibitor domain 29 - 172 IPR006501
active_site Pectinesterase, Asp active site 358 - 367 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MASSSSISNH KIPNTLMFLV IVNFLYLIQT NSAVSISSNS NSHFSRFSRH RSSPSSKTKQ
70 80 90 100 110 120
GFLATVQESM NHALLARSLA FNLTLSHRTV QTHTFDPIHD CLELLDDTLD MLSRIHADND
130 140 150 160 170 180
EEDVHTWLSA ALTNQDTCEQ SLQEKSESYK HGLAMDFVAR NLTGLLTSSL DLFVSVKSKH
190 200 210 220 230 240
RKLLSKQEYF PTFVPSSEQR RLLEAPVEEL NVDAVVAPDG SGTHKTIGEA LLSTSLASSG
250 260 270 280 290 300
GRTKIYLKAG TYHENINIPT KQKNVMLVGD GKGKTVIVGS RSNRGGWTTY KTATVAAMGE
310 320 330 340 350 360
GFIARDMTFV NNAGPKSEQA VALRVGADKS VVHRCSVEGY QDSLYTHSKR QFYRETDITG
370 380 390 400 410 420
TVDFIFGNSA VVFQSCNIAA RKPLPGQRNF VTAQGRSNPG QNTGIAIQNC RITAESMTYL
430 440 450 460 470 480
GRPWKEYSRT VVMQSFIGGS IHPSGWSPWS GGFGLKSLFY GEYGNSGPGS SVSGRVKWSG
490 500 510
CHPSLTVTEA EKFTVASFID GNIWLPSTGV SFDPGLVN