Q9LXD9
SS
Gene name |
PME51 (ARATH51, At5g09760, F17I14.50) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor 51 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G09760 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
240-544 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q9LXD9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9LXD9-F1 | Predicted | AlphaFoldDB |
47 variants for Q9LXD9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH06945203 | 3 | S>T | No | 1000Genomes | |
| tmp_5_3032458_C_G | 5 | L>V | No | 1000Genomes | |
| ENSVATH10670462 | 29 | S>P | No | 1000Genomes | |
| ENSVATH03041300 | 31 | D>E | No | 1000Genomes | |
| ENSVATH00613649 | 59 | V>L | No | 1000Genomes | |
| ENSVATH06945208 | 65 | Q>P | No | 1000Genomes | |
| tmp_5_3032651_C_T | 69 | P>L | No | 1000Genomes | |
| ENSVATH10670463 | 79 | H>Y | No | 1000Genomes | |
| ENSVATH06945211 | 90 | K>N | No | 1000Genomes | |
| tmp_5_3032730_A_T | 95 | K>N | No | 1000Genomes | |
| ENSVATH00613651 | 107 | L>R | No | 1000Genomes | |
| tmp_5_3032812_T_A | 123 | S>T | No | 1000Genomes | |
| ENSVATH06945213 | 131 | D>N | No | 1000Genomes | |
| ENSVATH00613653 | 167 | S>R | No | 1000Genomes | |
| tmp_5_3032944_A_C | 167 | S>R | No | 1000Genomes | |
| ENSVATH10670487 | 170 | G>A | No | 1000Genomes | |
| ENSVATH13972321 | 172 | T>A | No | 1000Genomes | |
| ENSVATH10670489 | 178 | G>R | No | 1000Genomes | |
| tmp_5_3033016_G_A | 191 | V>I | No | 1000Genomes | |
| ENSVATH06945215 | 194 | D>N | No | 1000Genomes | |
| ENSVATH00613654 | 216 | K>N | No | 1000Genomes | |
| tmp_5_3033094_A_G | 217 | T>A | No | 1000Genomes | |
| ENSVATH03041304 | 218 | G>R | No | 1000Genomes | |
| tmp_5_3033103_G_A | 220 | G>S | No | 1000Genomes | |
| ENSVATH03041305 | 221 | L>F | No | 1000Genomes | |
| ENSVATH03041306 | 223 | L>S | No | 1000Genomes | |
| ENSVATH03041308 | 227 | T>A | No | 1000Genomes | |
| tmp_5_3033142_T_G | 233 | F>V | No | 1000Genomes | |
| ENSVATH03041311 | 249 | C>Y | No | 1000Genomes | |
| tmp_5_3033273_A_C | 276 | E>D | No | 1000Genomes | |
| tmp_5_3033277_G_A | 278 | V>I | No | 1000Genomes | |
| ENSVATH06945218 | 284 | I>V | No | 1000Genomes | |
| ENSVATH10670491 | 294 | F>Y | No | 1000Genomes | |
| tmp_5_3033343_G_A | 300 | G>S | No | 1000Genomes | |
| ENSVATH06945219 | 312 | M>I | No | 1000Genomes | |
| ENSVATH03041314 | 313 | P>A | No | 1000Genomes | |
| tmp_5_3033406_G_C | 321 | A>P | No | 1000Genomes | |
| ENSVATH00613657 | 360 | I>L | No | 1000Genomes | |
| ENSVATH06945226 | 379 | Q>H | No | 1000Genomes | |
| tmp_5_3033853_A_G | 382 | K>R | No | 1000Genomes | |
| tmp_5_3033945_A_G | 413 | I>V | No | 1000Genomes | |
| tmp_5_3033965_G_C | 419 | E>D | No | 1000Genomes | |
| ENSVATH10670526 | 424 | T>S | No | 1000Genomes | |
| tmp_5_3033993_A_G | 429 | I>V | No | 1000Genomes | |
| tmp_5_3034260_T_C | 518 | S>P | No | 1000Genomes | |
| tmp_5_3034351_C_G | 548 | S>W | No | 1000Genomes | |
| tmp_5_3034357_C_T | 550 | S>F | No | 1000Genomes |
No associated diseases with Q9LXD9
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSILILLFS | LFLFSSPSSS | SRHHHHHNSG | DTSPVNPSSS | LAAQIRLACN | ATRYPDQCVS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLSEQGRVPP | DPKPIQIIHS | AISFSFQNLK | TAQSKIKSIV | DSSVGNLNRT | NAANTCLQLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TYSEHRTQST | DQALTRGKIK | DARAWMSAAL | VYQYDSWSAL | KYVNDTSQVG | ETMSFLDGLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| HVTSNALSMM | VSYDNFGDNV | ASWTYPATER | DGFWEKTGPG | LGLDPSTGLN | LGFPSGLKED |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTVCKDGKCG | YKTVQDAVNA | APEDNGMRKF | VIKISEGVYE | ENVIVPFEKK | NVVFIGDGMG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KTVITGSLNA | GMPGITTYNT | ATVGVVGDGF | MARDLTFQNT | AGPDAHQAVA | FRSDSDFSLI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ENCEFLGNQD | TLYAHGLRQF | YKNCRIQGNV | DFIFGNSAAV | FQDCEILIAP | RQINPEKGEK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NAVTAQGRID | PSQSTGFVFL | NCLINGTEEY | MKLFKANPKV | HKNFLGRPWK | DYSRTVFIGC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NLEALITPDG | WLPWSGDFAL | KTLYYGESKN | TGPGSDRSQR | VSWSSQIPDE | HVHVYSVANF |
| 550 | |||||
| IQADEWASMS | A |