O48711

SS
Gene name
PME12 (ARATH12, At2g26440, T9J22.11)
Protein name
Probable pectinesterase/pectinesterase inhibitor 12
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT2G26440
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

35-184 (PMEI region) SS

Target domain

238-533 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O48711

Entry ID Method Resolution Chain Position Source
AF-O48711-F1 Predicted AlphaFoldDB

40 variants for O48711

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05597002 6 F>L No 1000Genomes
tmp_2_11247428_C_A 8 L>I No 1000Genomes
ENSVATH13414045 18 T>S No 1000Genomes
ENSVATH13414046 19 P>S No 1000Genomes
tmp_2_11247542_T_A 46 Y>N No 1000Genomes
ENSVATH05597005 65 N>T No 1000Genomes
ENSVATH14555564 76 T>S No 1000Genomes
ENSVATH13414047 79 S>F No 1000Genomes
ENSVATH13414048 82 G>W No 1000Genomes
ENSVATH01900095 96 N>K No 1000Genomes
ENSVATH13414049 112 H>L No 1000Genomes
ENSVATH01900096 114 I>L No 1000Genomes
ENSVATH01900098 120 K>E No 1000Genomes
ENSVATH05597006 125 K>N No 1000Genomes
ENSVATH05597007 131 N>S No 1000Genomes
ENSVATH13414050 134 R>G No 1000Genomes
tmp_2_11247926_A_G 174 T>A No 1000Genomes
tmp_2_11247969_A_G 188 K>R No 1000Genomes
ENSVATH13414051 193 T>A No 1000Genomes
tmp_2_11247984_C_G 193 T>R No 1000Genomes
ENSVATH05597009 208 G>R No 1000Genomes
ENSVATH00249156 216 K>R No 1000Genomes
ENSVATH13414052 249 S>P No 1000Genomes
ENSVATH13414053 249 S>W No 1000Genomes
tmp_2_11248205_C_A 267 L>M No 1000Genomes
ENSVATH13414054 284 Y>N No 1000Genomes
ENSVATH05597012 317 T>A No 1000Genomes
tmp_2_11248750_T_G 329 D>E No 1000Genomes
tmp_2_11248883_C_A 374 Q>K No 1000Genomes
tmp_2_11248978_G_T 405 L>F No 1000Genomes
tmp_2_11249032_C_A 423 D>E No 1000Genomes
ENSVATH05597019 449 K>T No 1000Genomes
ENSVATH05597020 458 E>K No 1000Genomes
ENSVATH14555577 481 W>C No 1000Genomes
ENSVATH00249159 505 V>G No 1000Genomes
ENSVATH14555578 519 E>A No 1000Genomes
tmp_2_11249355_C_T 531 T>I No 1000Genomes
ENSVATH05597021 534 G>S No 1000Genomes
tmp_2_11249382_C_T 540 S>L No 1000Genomes
tmp_2_11249397_A_G 545 N>S No 1000Genomes

No associated diseases with O48711

4 regional properties for O48711

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 238 - 533 IPR000070
domain Pectinesterase inhibitor domain 5 - 189 IPR006501
active_site Pectinesterase, Tyr active site 262 - 281 IPR018040
active_site Pectinesterase, Asp active site 381 - 390 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

3 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN5 PME59 Probable pectinesterase/pectinesterase inhibitor 59 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MALSSFNLSS LLFLLFFTPS VFSYSYQPSL NPHETSATSF CKNTPYPDAC FTSLKLSISI
70 80 90 100 110 120
NISPNILSFL LQTLQTALSE AGKLTDLLSG AGVSNNLVEG QRGSLQDCKD LHHITSSFLK
130 140 150 160 170 180
RSISKIQDGV NDSRKLADAR AYLSAALTNK ITCLEGLESA SGPLKPKLVT SFTTTYKHIS
190 200 210 220 230 240
NSLSALPKQR RTTNPKTGGN TKNRRLLGLF PDWVYKKDHR FLEDSSDGYD EYDPSESLVV
250 260 270 280 290 300
AADGTGNFST INEAISFAPN MSNDRVLIYV KEGVYDENID IPIYKTNIVL IGDGSDVTFI
310 320 330 340 350 360
TGNRSVGDGW TTFRSATLAV SGEGFLARDI MITNTAGPEK HQAVALRVNA DFVALYRCVI
370 380 390 400 410 420
DGYQDTLYTH SFRQFYRECD IYGTIDYIFG NAAVVFQGCN IVSKLPMPGQ FTVITAQSRD
430 440 450 460 470 480
TQDEDTGISM QNCSILASED LFNSSNKVKS YLGRPWREFS RTVVMESYID EFIDGSGWSK
490 500 510 520 530 540
WNGGEALDTL YYGEYNNNGP GSETVKRVNW PGFHIMGYED AFNFTATEFI TGDGWLGSTS
FPYDNGI