Q5MFV6
SS
Gene name |
VGDH2 (ARATH37, At3g62170, T17J13.130) |
Protein name |
Probable pectinesterase/pectinesterase inhibitor VGDH2 |
Names |
VANGUARD1-like protein 2, VGD1-like protein 2 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G62170 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain and prevent untimely PME activity during transport.
Autoinhibitory domains (AIDs)
Target domain |
278-571 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q5MFV6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5MFV6-F1 | Predicted | AlphaFoldDB |
26 variants for Q5MFV6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH00431949 | 8 | V>I | No | 1000Genomes | |
| tmp_3_23018292_C_T | 16 | V>M | No | 1000Genomes | |
| ENSVATH02536288 | 36 | D>E | No | 1000Genomes | |
| ENSVATH02536288 | 36 | D>E | No | 1000Genomes | |
| tmp_3_23018224_A_C | 38 | N>K | No | 1000Genomes | |
| ENSVATH06359338 | 67 | P>L | No | 1000Genomes | |
| ENSVATH02536286 | 105 | N>K | No | 1000Genomes | |
| ENSVATH12880307 | 126 | E>D | No | 1000Genomes | |
| ENSVATH06359334 | 178 | E>D | No | 1000Genomes | |
| ENSVATH06359333 | 201 | M>I | No | 1000Genomes | |
| ENSVATH12880305 | 230 | D>Y | No | 1000Genomes | |
| tmp_3_23017580_C_T | 253 | R>H | No | 1000Genomes | |
| ENSVATH06359332 | 288 | K>N | No | 1000Genomes | |
| tmp_3_23017445_G_T | 298 | P>Q | No | 1000Genomes | |
| tmp_3_23017351_C_T | 329 | M>I | No | 1000Genomes | |
| tmp_3_23017349_A_G | 330 | F>S | No | 1000Genomes | |
| tmp_3_23017169_C_G | 365 | G>R | No | 1000Genomes | |
| tmp_3_23017147_C_A | 372 | G>V | No | 1000Genomes | |
| tmp_3_23016710_C_T | 518 | E>K | No | 1000Genomes | |
| tmp_3_23016664_T_C | 533 | K>R | No | 1000Genomes | |
| tmp_3_23016650_T_C | 538 | N>D | No | 1000Genomes | |
| ENSVATH06359328 | 545 | A>V | No | 1000Genomes | |
| tmp_3_23016620_G_C | 548 | Q>E | No | 1000Genomes | |
| tmp_3_23016589_G_A | 558 | S>F | No | 1000Genomes | |
| ENSVATH14468565 | 566 | T>S | No | 1000Genomes | |
| ENSVATH06359326 | 568 | A>V | No | 1000Genomes |
No associated diseases with Q5MFV6
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| pollen tube | A tubular cell projection that is part of a pollen tube cell and extends from a pollen grain. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8Z8 | PME28 | Putative pectinesterase/pectinesterase inhibitor 28 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAVGKVVVSV | ASLLLVVGVA | IGVITFVNKG | GGANGDSNGP | INSHQKAVQT | ICQSTTDQGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CAKTLDPVKS | DDPSKLVKAF | LMATKDAITK | SSNFTASTEG | GMGTNMNATS | KAVLDYCKRV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LMYALEDLET | IVEEMGEDLQ | QSGTKLDQLK | QWLTGVFNYQ | TDCLDDIEEV | ELKKIMGEGI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SNSKVLTSNA | IDIFHSVVTA | MAQMGVKVDD | MKNITMGAGA | GGAARRLLED | NDSKGLPKWF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SGKDRKLMAK | AGRGAPAGGD | DGIGEGGGGG | GKIKATHVVA | KDGSGQFKTI | SEAVMACPDK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPGRCIIHIK | AGIYNEQVRI | PKKKNNIFMF | GDGATQTIIT | FDRSVKLSPG | TTTSLSGTVQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VESEGFMAKW | IGFKNTAGPL | GHQAVALRVN | GDRAVIFNCR | FDGYQDTLYV | NNGRQFYRNI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VVSGTVDFIF | GKSATVIQNS | LILVRKGSPG | QSNYVTADGN | EKGAAMKIGI | VLHNCRIIPD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KELEADKLTI | KSYLGRPWKK | FATTVIIGTE | IGDLIKPEGW | TEWQGEQNHK | TAKYIEFNNR |
| 550 | 560 | 570 | 580 | ||
| GPGAATTQRP | PWVKVAKSAA | EVETYTVANW | VGPANWIQEA | NVPVQLGL |