Q3E8Z8
SS
Gene name |
PME28 (ARATH28, At5g27870, F14I23.30) |
Protein name |
Putative pectinesterase/pectinesterase inhibitor 28 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G27870 |
EC number |
3.1.1.11: Carboxylic ester hydrolases |
Protein Class |
|
Descriptions
(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.
Autoinhibitory domains (AIDs)
Target domain |
252-548 (Pectinesterase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for Q3E8Z8
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3E8Z8-F1 | Predicted | AlphaFoldDB |
120 variants for Q3E8Z8
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03148708 | 4 | G>V | No | 1000Genomes | |
| ENSVATH07071606 | 10 | A>P | No | 1000Genomes | |
| tmp_5_9881768_T_G | 13 | K>N | No | 1000Genomes | |
| ENSVATH03148707 | 18 | I>S | No | 1000Genomes | |
| ENSVATH07071604 | 18 | I>V | No | 1000Genomes | |
| tmp_5_9881734_G_T | 25 | L>I | No | 1000Genomes | |
| tmp_5_9881719_C_A | 30 | V>F | No | 1000Genomes | |
| tmp_5_9881718_A_C | 30 | V>G | No | 1000Genomes | |
| ENSVATH07071603 | 37 | V>F | No | 1000Genomes | |
| tmp_5_9881680_C_T | 43 | D>N | No | 1000Genomes | |
| tmp_5_9881641_C_T | 56 | A>T | No | 1000Genomes | |
| tmp_5_9881631_T_C | 59 | D>G | No | 1000Genomes | |
| tmp_5_9881620_G_T | 63 | P>T | No | 1000Genomes | |
| tmp_5_9881587_G_T | 74 | L>I | No | 1000Genomes | |
| tmp_5_9881583_C_T | 75 | R>K | No | 1000Genomes | |
| ENSVATH11183454 | 91 | A>V | No | 1000Genomes | |
| ENSVATH07071600 | 100 | S>G | No | 1000Genomes | |
| tmp_5_9881470_G_T | 113 | Q>K | No | 1000Genomes | |
| tmp_5_9881461_G_C | 116 | P>A | No | 1000Genomes | |
| tmp_5_9881450_C_A | 119 | K>N | No | 1000Genomes | |
| ENSVATH11183452 | 132 | A>G | No | 1000Genomes | |
| ENSVATH07071599 | 137 | S>N | No | 1000Genomes | |
| ENSVATH07071597 | 156 | V>I | No | 1000Genomes | |
| tmp_5_9881199_G_A | 203 | A>V | No | 1000Genomes | |
| tmp_5_9881137_G_A | 224 | R>W | No | 1000Genomes | |
| ENSVATH00655595 | 228 | Q>H | No | 1000Genomes | |
| ENSVATH00655593 | 234 | M>I | No | 1000Genomes | |
| ENSVATH11183448 | 236 | A>G | No | 1000Genomes | |
| tmp_5_9881068_A_G | 247 | S>P | No | 1000Genomes | |
| ENSVATH07071591 | 254 | V>L | No | 1000Genomes | |
| ENSVATH07071588 | 267 | N>D | No | 1000Genomes | |
| tmp_5_9880993_A_T | 272 | F>I | No | 1000Genomes | |
| ENSVATH07071587 | 272 | F>Y | No | 1000Genomes | |
| tmp_5_9880971_G_A | 279 | T>M | No | 1000Genomes | |
| ENSVATH07071585 | 283 | V>I | No | 1000Genomes | |
| tmp_5_9880932_T_G | 292 | E>A | No | 1000Genomes | |
| tmp_5_9880900_G_C | 303 | L>V | No | 1000Genomes | |
| ENSVATH07071582 | 307 | G>R | No | 1000Genomes | |
| ENSVATH14265253 | 315 | I>F | No | 1000Genomes | |
| ENSVATH14265252 | 316 | S>C | No | 1000Genomes | |
| ENSVATH00655588 | 318 | S>N | No | 1000Genomes | |
| tmp_5_9880820_T_G | 329 | K>N | No | 1000Genomes | |
| tmp_5_9880809_A_G | 333 | V>A | No | 1000Genomes | |
| tmp_5_9880132_G_T | 353 | A>E | No | 1000Genomes | |
| ENSVATH11183258 | 361 | I>S | No | 1000Genomes | |
| ENSVATH00655568 | 372 | N>K | No | 1000Genomes | |
| ENSVATH07071545 | 377 | G>S | No | 1000Genomes | |
| ENSVATH07071544 | 378 | Y>H | No | 1000Genomes | |
| ENSVATH11183257 | 387 | H>Q | No | 1000Genomes | |
| ENSVATH07071543 | 395 | T>I | No | 1000Genomes | |
| tmp_5_9879842_T_C | 450 | I>V | No | 1000Genomes | |
| tmp_5_9879760_G_A | 477 | T>I | No | 1000Genomes | |
| ENSVATH00655564 | 480 | M>I | No | 1000Genomes | |
| tmp_5_9879734_C_A | 486 | D>Y | No | 1000Genomes | |
| ENSVATH11183255 | 499 | E>K | No | 1000Genomes | |
| ENSVATH07071537 | 513 | T>A | No | 1000Genomes | |
| ENSVATH00655561 | 513 | T>I | No | 1000Genomes | |
| ENSVATH07071536 | 518 | A>T | No | 1000Genomes | |
| ENSVATH07071535 | 520 | T>A | No | 1000Genomes | |
| tmp_5_9879631_G_C | 520 | T>R | No | 1000Genomes | |
| ENSVATH03148659 | 533 | D>E | No | 1000Genomes | |
| ENSVATH07071533 | 534 | E>A | No | 1000Genomes | |
| tmp_5_9879581_G_A | 537 | L>F | No | 1000Genomes | |
| ENSVATH00655560 | 542 | A>S | No | 1000Genomes | |
| ENSVATH07071532 | 544 | Y>* | No | 1000Genomes | |
| ENSVATH07071531 | 556 | V>I | No | 1000Genomes | |
| tmp_5_9879516_G_T | 558 | Y>* | No | 1000Genomes | |
| ENSVATH00655558 | 560 | L>P | No | 1000Genomes | |
| ENSVATH07071528 | 564 | S>R | No | 1000Genomes | |
| ENSVATH03148658 | 582 | T>I | No | 1000Genomes | |
| ENSVATH14265084 | 588 | S>T | No | 1000Genomes | |
| tmp_5_9879419_T_A | 591 | T>S | No | 1000Genomes | |
| tmp_5_9879416_C_A | 592 | V>L | No | 1000Genomes | |
| ENSVATH03148657 | 594 | T>S | No | 1000Genomes | |
| ENSVATH03148656 | 596 | S>T | No | 1000Genomes | |
| ENSVATH07071521 | 601 | A>P | No | 1000Genomes | |
| ENSVATH07071521 | 601 | A>S | No | 1000Genomes | |
| ENSVATH03148655 | 602 | G>V | No | 1000Genomes | |
| ENSVATH03148653 | 603 | H>Q | No | 1000Genomes | |
| ENSVATH03148652 | 606 | S>A | No | 1000Genomes | |
| ENSVATH03148650 | 608 | S>P | No | 1000Genomes | |
| ENSVATH03148648 | 609 | D>A | No | 1000Genomes | |
| ENSVATH03148648 | 609 | D>V | No | 1000Genomes | |
| ENSVATH07071520 | 610 | T>R | No | 1000Genomes | |
| tmp_5_9879358_G_T | 611 | P>H | No | 1000Genomes | |
| tmp_5_9879353_A_T | 613 | S>T | No | 1000Genomes | |
| ENSVATH00655554 | 614 | V>L | No | 1000Genomes | |
| ENSVATH11183222 | 617 | P>L | No | 1000Genomes | |
| ENSVATH03148647 | 621 | L>P | No | 1000Genomes | |
| tmp_5_9879319_C_T | 624 | G>D | No | 1000Genomes | |
| ENSVATH03148645 | 625 | Q>K | No | 1000Genomes | |
| tmp_5_9879304_G_C | 629 | P>R | No | 1000Genomes | |
| ENSVATH08438882 | 635 | M>V | No | 1000Genomes | |
| ENSVATH07071518 | 646 | G>V | No | 1000Genomes | |
| tmp_5_9879248_G_T | 648 | L>I | No | 1000Genomes | |
| ENSVATH03148643 | 651 | P>L | No | 1000Genomes | |
| ENSVATH03148642 | 662 | S>T | No | 1000Genomes | |
| ENSVATH03148641 | 671 | G>A | No | 1000Genomes | |
| ENSVATH03148641 | 671 | G>D | No | 1000Genomes | |
| ENSVATH11183219 | 671 | G>S | No | 1000Genomes | |
| ENSVATH03148640 | 672 | S>T | No | 1000Genomes | |
| ENSVATH07071514 | 673 | P>L | No | 1000Genomes | |
| tmp_5_9879158_A_T | 678 | S>T | No | 1000Genomes | |
| tmp_5_9879154_G_A | 679 | S>L | No | 1000Genomes | |
| ENSVATH14265079 | 681 | V>L | No | 1000Genomes | |
| ENSVATH07071513 | 689 | T>I | No | 1000Genomes | |
| tmp_5_9879113_C_T | 693 | A>T | No | 1000Genomes | |
| tmp_5_9879106_G_A | 695 | P>L | No | 1000Genomes | |
| ENSVATH03148636 | 697 | V>A | No | 1000Genomes | |
| ENSVATH03148637 | 697 | V>I | No | 1000Genomes | |
| ENSVATH07071512 | 701 | A>V | No | 1000Genomes | |
| ENSVATH03148635 | 702 | F>S | No | 1000Genomes | |
| tmp_5_9879077_CAGA_TAGA,C | 705 | A>T | No | 1000Genomes | |
| tmp_5_9879070_G_T | 707 | P>Q | No | 1000Genomes | |
| ENSVATH07071511 | 711 | P>S | No | 1000Genomes | |
| tmp_5_9879040_A_G | 717 | V>A | No | 1000Genomes | |
| ENSVATH03148633 | 717 | V>F | No | 1000Genomes | |
| ENSVATH03148632 | 721 | A>T | No | 1000Genomes | |
| ENSVATH03148631 | 723 | P>R | No | 1000Genomes | |
| ENSVATH00655553 | 731 | I>V | No | 1000Genomes |
No associated diseases with Q3E8Z8
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.1.11 | Carboxylic ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartyl esterase activity | Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. |
| pectinesterase activity | Catalysis of the reaction: pectin + n H2O = n methanol + pectate. |
| pectinesterase inhibitor activity | Binds to and stops, prevents or reduces the activity of pectinesterase. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cell wall modification | The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. |
| pectin catabolic process | The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues. |
42 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O23447 | PME43 | Putative pectinesterase/pectinesterase inhibitor 43 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GX86 | PME21 | Probable pectinesterase/pectinesterase inhibitor 21 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SRX4 | PME7 | Probable pectinesterase/pectinesterase inhibitor 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1JPL7 | PME18 | Pectinesterase/pectinesterase inhibitor 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84JX1 | PME19 | Probable pectinesterase/pectinesterase inhibitor 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49298 | PME6 | Probable pectinesterase/pectinesterase inhibitor 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q42534 | PME2 | Pectinesterase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q43867 | PME1 | Pectinesterase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O48711 | PME12 | Probable pectinesterase/pectinesterase inhibitor 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q7Y201 | PME13 | Probable pectinesterase/pectinesterase inhibitor 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SKX2 | PME16 | Probable pectinesterase/pectinesterase inhibitor 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22149 | PME17 | Probable pectinesterase/pectinesterase inhibitor 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O80722 | PME4 | Pectinesterase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV8 | PME5 | Pectinesterase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O22256 | PME20 | Probable pectinesterase/pectinesterase inhibitor 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M9W7 | PME22 | Putative pectinesterase/pectinesterase inhibitor 22 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GXA1 | PME23 | Probable pectinesterase/pectinesterase inhibitor 23 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SG77 | PME24 | Putative pectinesterase/pectinesterase inhibitor 24 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O49006 | PME3 | Pectinesterase/pectinesterase inhibitor 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9STY3 | PME33 | Probable pectinesterase/pectinesterase inhibitor 33 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LYT5 | PME35 | Probable pectinesterase/pectinesterase inhibitor 35 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84R10 | PME36 | Probable pectinesterase/pectinesterase inhibitor 36 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q5MFV6 | VGDH2 | Probable pectinesterase/pectinesterase inhibitor VGDH2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81320 | PME38 | Putative pectinesterase/pectinesterase inhibitor 38 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81415 | PME39 | Probable pectinesterase/pectinesterase inhibitor 39 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81301 | PME40 | Probable pectinesterase/pectinesterase inhibitor 40 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8RXK7 | PME41 | Probable pectinesterase/pectinesterase inhibitor 41 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q1PEC0 | PME42 | Probable pectinesterase/pectinesterase inhibitor 42 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY7 | PME44 | Probable pectinesterase/pectinesterase inhibitor 44 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SMY6 | PME45 | Putative pectinesterase/pectinesterase inhibitor 45 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF78 | PME46 | Probable pectinesterase/pectinesterase inhibitor 46 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FF77 | PME47 | Probable pectinesterase/pectinesterase inhibitor 47 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXD9 | PME51 | Probable pectinesterase/pectinesterase inhibitor 51 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E989 | PME54 | Probable pectinesterase/pectinesterase inhibitor 54 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FJ21 | PME58 | Probable pectinesterase/pectinesterase inhibitor 58 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN5 | PME59 | Probable pectinesterase/pectinesterase inhibitor 59 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FHN4 | PME60 | Probable pectinesterase/pectinesterase inhibitor 60 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FK05 | PME61 | Probable pectinesterase/pectinesterase inhibitor 61 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8L7Q7 | PME64 | Probable pectinesterase/pectinesterase inhibitor 64 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q94CB1 | PME25 | Probable pectinesterase/pectinesterase inhibitor 25 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LXK7 | PME32 | Probable pectinesterase/pectinesterase inhibitor 32 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M3B0 | PME34 | Probable pectinesterase/pectinesterase inhibitor 34 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYGYDDEDA | KRKKRYVIIS | ISSVLLISMV | VAVTIGVSVN | KSDNAGDEEI | TTSVKAIKDV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CAPTDYKETC | EDTLRKDAKD | TSDPLELVKT | AFNATMKQIS | DVAKKSQTMI | ELQKDPRAKM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ALDQCKELMD | YAIGELSKSF | EELGKFEFHK | VDEALVKLRI | WLSATISHEQ | TCLDGFQGTQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GNAGETIKKA | LKTAVQLTHN | GLAMVTEMSN | YLGQMQIPEM | NSRRLLSQEF | PSWMDARARR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LLNAPMSEVK | PDIVVAQDGS | GQYKTINEAL | NFVPKKKNTT | FVVHIKEGIY | KEYVQVNRSM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| THLVFIGDGP | DKTVISGSKS | YKDGITTYKT | ATVAIVGDHF | IAKNIAFENT | AGAIKHQAVA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IRVLADESIF | YNCKFDGYQD | TLYAHSHRQF | YRDCTISGTI | DFLFGDAAAV | FQNCTLLVRK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PLLNQACPIT | AHGRKDPRES | TGFVLQGCTI | VGEPDYLAVK | EQSKTYLGRP | WKEYSRTIIM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NTFIPDFVPP | EGWQPWLGEF | GLNTLFYSEV | QNTGPGAAIT | KRVTWPGIKK | LSDEEILKFT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PAQYIQGDAW | IPGKGVPYIL | GLFSGNGSTN | STVTGSSLSS | NTTESSDSPS | TVVTPSTSPP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| AGHLGSPSDT | PSSVVSPSTS | LPAGQLGAPP | ATPSMVVSPS | TSPPAGHLGS | PSDTPSSLVS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PSTSPPAGHL | GSPSDTPSSV | VTPSASPSTS | PSASPSVSPS | AFPSASPSAS | PSASPSVSPS |
| 730 | |||||
| ASPSASPQSS | IG |