Q9FHN5

SS
Gene name
PME59 (ARATH59, At5g51490, K17N15.4)
Protein name
Probable pectinesterase/pectinesterase inhibitor 59
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G51490
EC number
3.1.1.11: Carboxylic ester hydrolases
Protein Class

Descriptions

(Annotation from UniProt)
The PMEI region may act as an autoinhibitory domain.

Autoinhibitory domains (AIDs)

33-183 (PMEI region) SS

Target domain

221-521 (Pectinesterase domain)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9FHN5

Entry ID Method Resolution Chain Position Source
AF-Q9FHN5-F1 Predicted AlphaFoldDB

35 variants for Q9FHN5

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12701476 3 M>I No 1000Genomes
ENSVATH07395496 8 L>F No 1000Genomes
tmp_5_20915476_G_C 44 P>R No 1000Genomes
tmp_5_20915407_C_T 67 R>Q No 1000Genomes
ENSVATH07395494 68 V>E No 1000Genomes
tmp_5_20915393_C_T 72 E>K No 1000Genomes
ENSVATH12701475 98 Q>R No 1000Genomes
ENSVATH12701464 102 A>V No 1000Genomes
ENSVATH03409212 110 D>E No 1000Genomes
ENSVATH07395491 124 P>R No 1000Genomes
ENSVATH03409211 129 A>E No 1000Genomes
ENSVATH03409211 129 A>V No 1000Genomes
ENSVATH07395490 135 F>L No 1000Genomes
ENSVATH03409208 155 S>T No 1000Genomes
ENSVATH03409207 158 L>F No 1000Genomes
ENSVATH03409206 161 T>S No 1000Genomes
ENSVATH07395488 175 H>Y No 1000Genomes
ENSVATH03409204 189 T>P No 1000Genomes
ENSVATH14625815 196 T>A No 1000Genomes
ENSVATH00726800 197 T>S No 1000Genomes
tmp_5_20915008_T_G 200 Q>P No 1000Genomes
tmp_5_20914984_G_C 208 S>C No 1000Genomes
ENSVATH12701462 223 V>M No 1000Genomes
ENSVATH07395486 233 N>K No 1000Genomes
ENSVATH12701459 240 D>E No 1000Genomes
ENSVATH07395484 273 D>N No 1000Genomes
tmp_5_20914741_C_A 289 G>V No 1000Genomes
tmp_5_20914708_T_C 300 N>S No 1000Genomes
ENSVATH07395479 347 E>Q No 1000Genomes
ENSVATH14625773 394 K>R No 1000Genomes
tmp_5_20914003_C_T 430 V>M No 1000Genomes
ENSVATH14625772 452 Q>H No 1000Genomes
tmp_5_20913921_T_A 457 N>I No 1000Genomes
ENSVATH12701423 507 A>P No 1000Genomes
tmp_5_20913711_C_T 527 R>H No 1000Genomes

No associated diseases with Q9FHN5

4 regional properties for Q9FHN5

Type Name Position InterPro Accession
domain Pectinesterase, catalytic 221 - 521 IPR000070
domain Pectinesterase inhibitor domain 8 - 186 IPR006501
active_site Pectinesterase, Tyr active site 248 - 267 IPR018040
active_site Pectinesterase, Asp active site 367 - 376 IPR033131

Functions

Description
EC Number 3.1.1.11 Carboxylic ester hydrolases
Subcellular Localization
  • Secreted, cell wall
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

3 GO annotations of molecular function

Name Definition
aspartyl esterase activity Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.
pectinesterase activity Catalysis of the reaction: pectin + n H2O = n methanol + pectate.
pectinesterase inhibitor activity Binds to and stops, prevents or reduces the activity of pectinesterase.

2 GO annotations of biological process

Name Definition
cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.
pectin catabolic process The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.

42 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9FHN4 PME60 Probable pectinesterase/pectinesterase inhibitor 60 Arabidopsis thaliana (Mouse-ear cress) SS
Q9STY3 PME33 Probable pectinesterase/pectinesterase inhibitor 33 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SRX4 PME7 Probable pectinesterase/pectinesterase inhibitor 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q1JPL7 PME18 Pectinesterase/pectinesterase inhibitor 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q84JX1 PME19 Probable pectinesterase/pectinesterase inhibitor 19 Arabidopsis thaliana (Mouse-ear cress) SS
O49298 PME6 Probable pectinesterase/pectinesterase inhibitor 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q42534 PME2 Pectinesterase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q43867 PME1 Pectinesterase 1 Arabidopsis thaliana (Mouse-ear cress) SS
O48711 PME12 Probable pectinesterase/pectinesterase inhibitor 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q7Y201 PME13 Probable pectinesterase/pectinesterase inhibitor 13 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SKX2 PME16 Probable pectinesterase/pectinesterase inhibitor 16 Arabidopsis thaliana (Mouse-ear cress) SS
O22149 PME17 Probable pectinesterase/pectinesterase inhibitor 17 Arabidopsis thaliana (Mouse-ear cress) SS
O80722 PME4 Pectinesterase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV8 PME5 Pectinesterase 5 Arabidopsis thaliana (Mouse-ear cress) SS
O22256 PME20 Probable pectinesterase/pectinesterase inhibitor 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GX86 PME21 Probable pectinesterase/pectinesterase inhibitor 21 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M9W7 PME22 Putative pectinesterase/pectinesterase inhibitor 22 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GXA1 PME23 Probable pectinesterase/pectinesterase inhibitor 23 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SG77 PME24 Putative pectinesterase/pectinesterase inhibitor 24 Arabidopsis thaliana (Mouse-ear cress) SS
O49006 PME3 Pectinesterase/pectinesterase inhibitor 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LYT5 PME35 Probable pectinesterase/pectinesterase inhibitor 35 Arabidopsis thaliana (Mouse-ear cress) SS
Q84R10 PME36 Probable pectinesterase/pectinesterase inhibitor 36 Arabidopsis thaliana (Mouse-ear cress) SS
Q5MFV6 VGDH2 Probable pectinesterase/pectinesterase inhibitor VGDH2 Arabidopsis thaliana (Mouse-ear cress) SS
O81320 PME38 Putative pectinesterase/pectinesterase inhibitor 38 Arabidopsis thaliana (Mouse-ear cress) SS
O81415 PME39 Probable pectinesterase/pectinesterase inhibitor 39 Arabidopsis thaliana (Mouse-ear cress) SS
O81301 PME40 Probable pectinesterase/pectinesterase inhibitor 40 Arabidopsis thaliana (Mouse-ear cress) SS
Q8RXK7 PME41 Probable pectinesterase/pectinesterase inhibitor 41 Arabidopsis thaliana (Mouse-ear cress) SS
Q1PEC0 PME42 Probable pectinesterase/pectinesterase inhibitor 42 Arabidopsis thaliana (Mouse-ear cress) SS
O23447 PME43 Putative pectinesterase/pectinesterase inhibitor 43 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY7 PME44 Probable pectinesterase/pectinesterase inhibitor 44 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SMY6 PME45 Putative pectinesterase/pectinesterase inhibitor 45 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF78 PME46 Probable pectinesterase/pectinesterase inhibitor 46 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FF77 PME47 Probable pectinesterase/pectinesterase inhibitor 47 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXD9 PME51 Probable pectinesterase/pectinesterase inhibitor 51 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E989 PME54 Probable pectinesterase/pectinesterase inhibitor 54 Arabidopsis thaliana (Mouse-ear cress) SS
Q3E8Z8 PME28 Putative pectinesterase/pectinesterase inhibitor 28 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FJ21 PME58 Probable pectinesterase/pectinesterase inhibitor 58 Arabidopsis thaliana (Mouse-ear cress) SS
Q9FK05 PME61 Probable pectinesterase/pectinesterase inhibitor 61 Arabidopsis thaliana (Mouse-ear cress) SS
Q8L7Q7 PME64 Probable pectinesterase/pectinesterase inhibitor 64 Arabidopsis thaliana (Mouse-ear cress) SS
Q94CB1 PME25 Probable pectinesterase/pectinesterase inhibitor 25 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LXK7 PME32 Probable pectinesterase/pectinesterase inhibitor 32 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M3B0 PME34 Probable pectinesterase/pectinesterase inhibitor 34 Arabidopsis thaliana (Mouse-ear cress) SS
10 20 30 40 50 60
MNMMMQKLSI LFLHLILLVL LCVHPLTTVA DRNSTDWCDK TPYPDPCKCY FKNHNGFQQP
70 80 90 100 110 120
TQLSEFRVML VEAAMDRAIS ARAELTNSGK NCTDSKKQAV LADCIDLYGD TIMQLNRTLH
130 140 150 160 170 180
GVSPKAGAAK SCTDFDAQTW LSTALTNTET CRRGSSDLNV TDFITPIVSN TKISHLISNC
190 200 210 220 230 240
LAVNGALLTA GNKGNTTANQ KGFPTWLSRK DKRLLRAVRA NLVVAKDGSG HFNTVQAAID
250 260 270 280 290 300
VAGRRKVTSG RFVIYVKRGI YQENINVRLN NDDIMLVGDG MRSTIITGGR SVQGGYTTYN
310 320 330 340 350 360
SATAGIEGLH FIAKGITFRN TAGPAKGQAV ALRSSSDLSI FYKCSIEGYQ DTLMVHSQRQ
370 380 390 400 410 420
FYRECYIYGT VDFIFGNAAA VFQNCLILPR RPLKGQANVI TAQGRADPFQ NTGISIHNSR
430 440 450 460 470 480
ILPAPDLKPV VGTVKTYMGR PWMKFSRTVV LQTYLDNVVS PVGWSPWIEG SVFGLDTLFY
490 500 510 520 530
AEYKNTGPAS STRWRVSWKG FHVLGRASDA SAFTVGKFIA GTAWLPRTGI PFTSGL