Q9SIN1
PR
Gene name |
TTL3 (VIT, At2g42580, F14N22.15) |
Protein name |
Inactive TPR repeat-containing thioredoxin TTL3 |
Names |
Tetratricopeptide repeat thioredoxin-like 3, VH1-interacting TPR-containing protein |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT2G42580 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9SIN1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9SIN1-F1 | Predicted | AlphaFoldDB |
53 variants for Q9SIN1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14609328 | 6 | R>T | No | 1000Genomes | |
| tmp_2_17728930_A_T | 26 | N>Y | No | 1000Genomes | |
| tmp_2_17728984_G_A | 44 | V>I | No | 1000Genomes | |
| ENSVATH14609329 | 48 | M>T | No | 1000Genomes | |
| ENSVATH13620168 | 53 | A>T | No | 1000Genomes | |
| tmp_2_17729014_T_C | 54 | S>P | No | 1000Genomes | |
| ENSVATH05704565 | 58 | A>V | No | 1000Genomes | |
| ENSVATH00271476 | 86 | D>E | No | 1000Genomes | |
| tmp_2_17729249_C_T | 132 | T>I | No | 1000Genomes | |
| tmp_2_17729376_G_A | 174 | M>I | No | 1000Genomes | |
| ENSVATH01981465 | 206 | T>S | No | 1000Genomes | |
| tmp_2_17729489_G_A | 212 | R>K | No | 1000Genomes | |
| ENSVATH05704570 | 235 | S>N | No | 1000Genomes | |
| tmp_2_17729566_G_A | 238 | E>K | No | 1000Genomes | |
| tmp_2_17729668_G_A | 272 | E>K | No | 1000Genomes | |
| ENSVATH13620172 | 306 | N>D | No | 1000Genomes | |
| tmp_2_17729909_T_C | 323 | L>P | No | 1000Genomes | |
| tmp_2_17730010_G_A | 357 | A>T | No | 1000Genomes | |
| ENSVATH00271485 | 374 | F>L | No | 1000Genomes | |
| tmp_2_17730169_C_T | 383 | S>L | No | 1000Genomes | |
| ENSVATH05704576 | 409 | V>I | No | 1000Genomes | |
| ENSVATH05704577 | 412 | A>V | No | 1000Genomes | |
| ENSVATH00271486 | 439 | A>E | No | 1000Genomes | |
| ENSVATH00271486 | 439 | A>V | No | 1000Genomes | |
| ENSVATH05704579 | 441 | L>F | No | 1000Genomes | |
| ENSVATH00271487 | 459 | V>L | No | 1000Genomes | |
| tmp_2_17730487_C_T | 460 | R>W | No | 1000Genomes | |
| ENSVATH13620173 | 471 | S>L | No | 1000Genomes | |
| ENSVATH00271488 | 478 | C>S | No | 1000Genomes | |
| ENSVATH00271489 | 487 | Q>H | No | 1000Genomes | |
| tmp_2_17730634_G_T | 509 | E>* | No | 1000Genomes | |
| ENSVATH13620174 | 514 | D>E | No | 1000Genomes | |
| ENSVATH00271492 | 519 | L>I | No | 1000Genomes | |
| ENSVATH00271492 | 519 | L>V | No | 1000Genomes | |
| ENSVATH00271493 | 535 | S>A | No | 1000Genomes | |
| tmp_2_17730841_T_G | 551 | F>V | No | 1000Genomes | |
| tmp_2_17730884_C_T | 565 | S>F | No | 1000Genomes | |
| ENSVATH00271494 | 568 | R>S | No | 1000Genomes | |
| ENSVATH14609333 | 575 | N>S | No | 1000Genomes | |
| ENSVATH05704587 | 587 | N>I | No | 1000Genomes | |
| ENSVATH00271495 | 597 | K>E | No | 1000Genomes | |
| ENSVATH05704588 | 599 | K>N | No | 1000Genomes | |
| tmp_2_17731006_G_A | 606 | G>S | No | 1000Genomes | |
| ENSVATH14609334 | 614 | S>A | No | 1000Genomes | |
| ENSVATH05704590 | 617 | N>H | No | 1000Genomes | |
| ENSVATH00271496 | 617 | N>T | No | 1000Genomes | |
| ENSVATH13620186 | 618 | R>Q | No | 1000Genomes | |
| tmp_2_17731144_C_T | 624 | S>F | No | 1000Genomes | |
| ENSVATH13620188 | 649 | A>G | No | 1000Genomes | |
| tmp_2_17731363_C_T | 660 | P>S | No | 1000Genomes | |
| ENSVATH13620189 | 664 | M>I | No | 1000Genomes | |
| ENSVATH01981470 | 670 | K>I | No | 1000Genomes | |
| ENSVATH05704594 | 686 | I>V | No | 1000Genomes |
No associated diseases with Q9SIN1
7 regional properties for Q9SIN1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thioredoxin domain | 594 - 679 | IPR013766 |
| repeat | Tetratricopeptide repeat | 220 - 253 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 254 - 287 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 412 - 445 | IPR019734-3 |
| repeat | Tetratricopeptide repeat | 458 - 491 | IPR019734-4 |
| repeat | Tetratricopeptide repeat | 492 - 525 | IPR019734-5 |
| repeat | Tetratricopeptide repeat | 526 - 559 | IPR019734-6 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| auxin-activated signaling pathway | The series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription. |
| brassinosteroid mediated signaling pathway | The series of molecular signals mediated by the detection of brassinosteroid. |
| leaf vascular tissue pattern formation | Vascular tissue pattern formation as it occurs in the leaf of vascular plants. |
| response to osmotic stress | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N427 | NME8 | Thioredoxin domain-containing protein 3 | Homo sapiens (Human) | PR |
| Q80ZX8 | Spag1 | Sperm-associated antigen 1 | Mus musculus (Mouse) | PR |
| Q8S091 | Os01g0913000 | Thioredoxin F, chloroplastic | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z4I3 | Os07g0190800 | Thioredoxin H2-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q9CAS1 | TRX8 | Thioredoxin H8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VWG7 | TDX | TPR repeat-containing thioredoxin TDX | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZT6 | WCRKC2 | Thioredoxin-like 3-2, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q84JR9 | TTL4 | TPR repeat-containing thioredoxin TTL4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSHSRRLSLE | PAIDSITGRF | RDLQRNDDDV | NKPDFRELDL | GSPVSTLMPR | GSASSSAAAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PTSSSGSSGS | ASGKPSVSSQ | MAKRLDDAYK | SHSGELSSPG | SGMPTTTRIL | KPGHRRSSST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTPLIFSGSS | FTSATSHTSP | QGGGSGATSA | VSPNTGVLPA | GNICPSGRIL | KTGMASRTSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RTETLCTGTG | NYGHGNVVRS | GGGGGTSGKA | VRVAENGENP | EELKRMGNDM | YRRGSFSEAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLYDRAILIS | PGNAAYRSNR | AAALTALRRL | GEAVKECLEA | VRIDPSYSRA | HQRLASLYLR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LGEAENARRH | ICFSGQCPDQ | ADLQRLQTLE | KHLRRCWEAR | KIGDWKTAIK | ETDAAIANGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DSSPQLVACK | AEAFLRLKQI | EDSDFCVSCI | PRLDHHYHSQ | PQVKLFGMVV | EAYVLCIQAQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VDMALGRFEN | AVVKAERAAM | LDQTNPEVVS | VLNNVKMVVR | ARTRGNELFS | SGRFSEACVA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YGDGLKQDDS | NSVLYCNRAA | CWYKLGLWEK | SVEDCNHALK | SQPSYIKALL | RRAASYGKLG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RWEDAVKDYE | FLRRELPGDS | EVAESLERAK | TVLMNRSQES | KSLGFNNEVE | AVSTLDKFKK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SVALPGVSVF | HFKSSSNRQC | EEISPFINTL | CLRYPLVHFF | MVDVEESMAL | AKAESIRKVP |
| 670 | 680 | 690 | |||
| TFKMYKNGDK | VKEMVCPSHQ | FLEDSIKHFL | L |