AiPD: Autoinhibited Protein Database

Gene name	TDX (At3g17880/At3g17870, MEB5.10/MEB5.9)
Protein name	TPR repeat-containing thioredoxin TDX
Names	HSP70-interacting protein 2, AtHIP2, Tetratricoredoxin, AtTDX
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G17880
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

15-108 (Predicted disordered autoinhibitory region) PR

15-108 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8VWG7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH10750146	4	A>G	No	1000Genomes
ENSVATH00330141	5	I>S	No	1000Genomes
ENSVATH05853414	49	T>S	No	1000Genomes
tmp_3_6124036_A_G	75	M>V	No	1000Genomes
tmp_3_6124047_T_G	78	D>E	No	1000Genomes
tmp_3_6124064_C_T	84	S>F	No	1000Genomes
ENSVATH10750150	88	E>Q	No	1000Genomes
tmp_3_6124205_C_G	99	D>E	No	1000Genomes
tmp_3_6124212_G_T	102	A>S	No	1000Genomes
ENSVATH10750152	110	D>G	No	1000Genomes
ENSVATH00330148	118	K>T	No	1000Genomes
ENSVATH00330149	125	D>N	No	1000Genomes
ENSVATH05853419	134	H>Y	No	1000Genomes
tmp_3_6124530_G_C	155	V>L	No	1000Genomes
ENSVATH00330152	166	I>T	No	1000Genomes
ENSVATH10750153	167	R>P	No	1000Genomes
ENSVATH05853425	179	S>L	No	1000Genomes
ENSVATH00330154	189	A>S	No	1000Genomes
tmp_3_6124830_G_T	202	D>Y	No	1000Genomes
tmp_3_6124833_C_G	203	L>V	No	1000Genomes
ENSVATH13938571	228	R>K	No	1000Genomes
tmp_3_6124997_A_C	229	I>L	No	1000Genomes
tmp_3_6125009_C_T	233	R>C	No	1000Genomes
ENSVATH13938572	240	R>G	No	1000Genomes
ENSVATH13938573	255	Q>H	No	1000Genomes
tmp_3_6125076_A_G	255	Q>R	No	1000Genomes
ENSVATH13938574	265	A>V	No	1000Genomes
ENSVATH10750236	291	A>V	No	1000Genomes
tmp_3_6125874_A_T	302	T>S	No	1000Genomes
tmp_3_6125893_G_A	308	R>Q	No	1000Genomes
tmp_3_6125896_A_G	309	Y>C	No	1000Genomes
ENSVATH00330164	322	S>P	No	1000Genomes
ENSVATH05853441	360	K>N	No	1000Genomes
tmp_3_6126070_G_T	367	G>V	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Thioredoxin domain	252 - 378	IPR013766
conserved_site	Thioredoxin, conserved site	296 - 314	IPR017937
repeat	Tetratricopeptide repeat	112 - 145	IPR019734-1
repeat	Tetratricopeptide repeat	146 - 179	IPR019734-2
repeat	Tetratricopeptide repeat	180 - 213	IPR019734-3
domain	Hsp70-interacting protein, N-terminal	3 - 44	IPR034649

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
histone deacetylase complex	A protein complex that possesses histone deacetylase activity.

Name	Definition
Hsp70 protein binding	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
identical protein binding	Binding to an identical protein or proteins.
oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide.
protein dimerization activity	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

Name	Definition
chaperone cofactor-dependent protein refolding	The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release.
heat acclimation	Any process that increases heat tolerance of an organism in response to high temperatures.
protein complex oligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8N427	NME8	Thioredoxin domain-containing protein 3	Homo sapiens (Human)	PR
Q8S091	Os01g0913000	Thioredoxin F, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
Q6Z4I3	Os07g0190800	Thioredoxin H2-1	Oryza sativa subsp japonica (Rice)	PR
Q9CAS1	TRX8	Thioredoxin H8	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SIN1	TTL3	Inactive TPR repeat-containing thioredoxin TTL3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q84JR9	TTL4	TPR repeat-containing thioredoxin TTL4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8VZT6	WCRKC2	Thioredoxin-like 3-2, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR