Q9R092

PR
Gene name
Hsd17b6 (Gm182, Hsd17b9, Rdh8)
Protein name
17-beta-hydroxysteroid dehydrogenase type 6
Names
17-beta-HSD 6, 17-beta-HSD6, 17-beta-HSD9, 3-alpha->beta-hydroxysteroid epimerase, 3-alpha->beta-HSE, Oxidative 3-alpha hydroxysteroid dehydrogenase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:27400
EC number
1.1.1.53: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9R092

Entry ID Method Resolution Chain Position Source
AF-Q9R092-F1 Predicted AlphaFoldDB

14 variants for Q9R092

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389098932 12 Y>* No EVA
rs3389145237 57 L>* No EVA
rs255401265 63 E>K No EVA
rs220453773 68 E>Q No EVA
rs3389145248 72 K>N No EVA
rs234845224 100 R>C No EVA
rs3389135759 155 A>V No EVA
rs238454963 156 R>Q No EVA
rs3389142928 184 E>Q No EVA
rs232685361 194 V>I No EVA
rs258551132 275 T>M No EVA
rs245268574 290 F>L No EVA
rs3389142909 296 Y>F No EVA
rs257694648 299 A>T No EVA

No associated diseases with Q9R092

1 regional properties for Q9R092

Type Name Position InterPro Accession
conserved_site Short-chain dehydrogenase/reductase, conserved site 163 - 191 IPR020904

Functions

Description
EC Number 1.1.1.53 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Microsome membrane ; Peripheral membrane protein ; Lumenal side
  • Early endosome membrane ; Peripheral membrane protein ; Lumenal side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
early endosome membrane The lipid bilayer surrounding an early endosome.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

10 GO annotations of molecular function

Name Definition
17-beta-hydroxysteroid dehydrogenase (NAD+) activity Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+.
5alpha-androstane-3beta,17beta-diol dehydrogenase activity Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH.
androstan-3-alpha,17-beta-diol dehydrogenase activity Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+.
androsterone dehydrogenase activity Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione.
estradiol 17-beta-dehydrogenase activity Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.
NAD-retinol dehydrogenase activity Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
steroid dehydrogenase activity Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.
testosterone 17-beta-dehydrogenase (NADP+) activity Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione.
testosterone dehydrogenase (NAD+) activity Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH.

3 GO annotations of biological process

Name Definition
brexanolone catabolic process The chemical reactions and pathways resulting in the breakdown of brexanolone.
retinol metabolic process The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.
steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q02337 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial Bos taurus (Bovine) PR
Q8NEX9 SDR9C7 Short-chain dehydrogenase/reductase family 9C member 7 Homo sapiens (Human) PR
P80365 HSD11B2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens (Human) PR
Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial Homo sapiens (Human) PR
O75452 RDH16 Retinol dehydrogenase 16 Homo sapiens (Human) PR
P50233 Hsd11b2 11-beta-hydroxysteroid dehydrogenase type 2 Rattus norvegicus (Rat) PR
O54753 Hsd17b6 17-beta-hydroxysteroid dehydrogenase type 6 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MWFYLVTLVG LYHLLRWYRE RQVVSHLQDK YVFITGCDSG FGNLLARQLD RRGMRVLAAC
70 80 90 100 110 120
LTEKGAEELR NKTSDRLETV ILDVTKTESI VAATQWVKER VGDRGLWGLV NNAGVLQPFA
130 140 150 160 170 180
YIEWYRPEDY MPIFQVNLIG LTQVTISMLF LVKKARGRIV NVSSALGRVA LFGGFYSCSK
190 200 210 220 230 240
YGVEAFSDVL RHEVQDFGVK VSIIEPGSFK TEMTDAELTI ERTKKVWEAA PEHIKESYGQ
250 260 270 280 290 300
QFFDDFCSTT KRELMKCSRN LSLVTDCMEH ALTSTHPRTR YSAGWDAKFF FIPLSYLPAS
310
LVDYLLAISR GKPAQAA