O54753
Gene name |
Hsd17b6 (Hsd17b9) |
Protein name |
17-beta-hydroxysteroid dehydrogenase type 6 |
Names |
17-beta-HSD 6, 17-beta-HSD6, 3-alpha->beta-hydroxysteroid epimerase, 3-alpha->beta-HSE, Oxidative 3-alpha hydroxysteroid dehydrogenase |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:286964 |
EC number |
1.1.1.53: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O54753
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O54753-F1 | Predicted | AlphaFoldDB |
No variants for O54753
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O54753 | |||||
No associated diseases with O54753
1 regional properties for O54753
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | NAC domain | 3 - 147 | IPR003441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.1.53 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
10 GO annotations of molecular function
| Name | Definition |
|---|---|
| 17-beta-hydroxysteroid dehydrogenase (NAD+) activity | Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+. |
| 5alpha-androstane-3beta,17beta-diol dehydrogenase activity | Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP(+) = 17beta-hydroxy-5alpha-androstan-3-one + H(+) + NADPH. |
| androstan-3-alpha,17-beta-diol dehydrogenase activity | Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. |
| androsterone dehydrogenase activity | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. |
| estradiol 17-beta-dehydrogenase activity | Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. |
| NAD-retinol dehydrogenase activity | Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
| steroid dehydrogenase activity | Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. |
| testosterone 17-beta-dehydrogenase (NADP+) activity | Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. |
| testosterone dehydrogenase (NAD+) activity | Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| androgen metabolic process | The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. |
| brexanolone catabolic process | The chemical reactions and pathways resulting in the breakdown of brexanolone. |
| retinol metabolic process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. |
| steroid metabolic process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02337 | BDH1 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial | Bos taurus (Bovine) | PR |
| Q8NEX9 | SDR9C7 | Short-chain dehydrogenase/reductase family 9C member 7 | Homo sapiens (Human) | PR |
| P80365 | HSD11B2 | 11-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (Human) | PR |
| Q02338 | BDH1 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial | Homo sapiens (Human) | PR |
| O75452 | RDH16 | Retinol dehydrogenase 16 | Homo sapiens (Human) | PR |
| Q9R092 | Hsd17b6 | 17-beta-hydroxysteroid dehydrogenase type 6 | Mus musculus (Mouse) | PR |
| P50233 | Hsd11b2 | 11-beta-hydroxysteroid dehydrogenase type 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWFYLVTLVG | LYYLLRWYRE | RQVVSHLHDK | YVFITGCDSG | FGNLLARQLD | RRGMRVLAAC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LTEKGAEELK | SKTSDRLETV | ILDVTNTDSI | SAATQWVKEH | VGDKGLWGLV | NNAGVFQAFA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YIEWCRPEDC | MSIFQVNLIG | LAQVTLSMLF | LVKKARGRIV | NVSSVLGRVA | LFGGFYSCSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YGVEAFSDVL | RREIRDFGVK | VSIIEPGSFK | TRMTDAELII | EKTKKTWEAT | PEHIRESYGQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QFFDDFCNTT | RRELKKCSTN | LSLVTDCMEH | ALTSKYPRTR | YSAGWDARLF | FIPLSYLPTS |
| 310 | |||||
| LVDCLLAISR | RKPAQAV |