Q02337

PR
Gene name
BDH1
Protein name
D-beta-hydroxybutyrate dehydrogenase, mitochondrial
Names
3-hydroxybutyrate dehydrogenase, BDH
Species
Bos taurus (Bovine)
KEGG Pathway
bta:534090
EC number
1.1.1.30: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-154 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q02337

Entry ID Method Resolution Chain Position Source
AF-Q02337-F1 Predicted AlphaFoldDB

69 variants for Q02337

Variant ID(s) Position Change Description Diseaes Association Provenance
rs439067297 31 L>P No EVA
rs476801669 32 L>P No EVA
rs456985937 33 L>V No EVA
rs474591397 34 Y>* No EVA
rs436892176 34 Y>F No EVA
rs436892176 34 Y>S No EVA
rs434663697 36 A>P No EVA
rs445802711 38 F>L No EVA
rs432107270 39 V>F No EVA
rs467787518 44 R>W No EVA
rs469819250 45 T>A No EVA
rs440866930 55 S>R No EVA
rs478539841 82 V>A No EVA
rs473998803 90 D>G No EVA
rs454185630 91 K>* No EVA
rs454185630 91 K>Q No EVA
rs434088132 92 G>R No EVA
rs471770720 93 S>C No EVA
rs471770720 93 S>G No EVA
rs451711595 93 S>R No EVA
rs469746402 94 D>E No EVA
rs438274832 94 D>G No EVA
rs438274832 94 D>V No EVA
rs435712124 95 G>V No EVA
rs449504617 95 G>W No EVA
rs447275162 96 V>G No EVA
rs467020289 96 V>L No EVA
rs458463882 97 K>Q No EVA
rs444873689 99 L>M No EVA
rs482989655 101 S>I No EVA
rs720516308 102 M>I No EVA
rs442707636 104 S>R No EVA
rs462807195 104 S>T No EVA
rs460361322 120 V>G No EVA
rs209491534 123 A>V No EVA
rs471930805 126 V>G No EVA
rs444375538 133 D>G No EVA
rs455982038 135 E>Q No EVA
rs449678484 139 W>G No EVA
rs436019161 142 V>G No EVA
rs447562342 149 T>S No EVA
rs478908394 152 D>G No EVA
rs458752204 155 F>V No EVA
rs445099302 187 K>E No EVA
rs459913484 190 V>A No EVA
rs440136901 192 N>K No EVA
rs471541881 197 M>L No EVA
rs451414640 201 A>D No EVA
rs444081849 203 V>A No EVA
rs475375762 206 S>A No EVA
rs455574495 215 V>M No EVA
rs435443193 217 A>S No EVA
rs473192466 221 C>W No EVA
rs453034728 234 S>T No EVA
rs432942760 235 V>G No EVA
rs464534498 237 E>D No EVA
rs455141358 245 T>P No EVA
rs136615966 251 T>A No EVA
rs136615966 251 T>P No EVA
rs468566872 252 E>D No EVA
rs448695344 282 V>I No EVA
rs480104384 288 Y>H No EVA
rs446305184 298 P>A No EVA
rs477583802 298 P>H No EVA
rs457859074 299 V>L No EVA
rs444116752 331 T>S No EVA
rs441896631 332 H>P No EVA
rs473375529 332 H>Q No EVA
rs461719157 332 H>Y No EVA

No associated diseases with Q02337

2 regional properties for Q02337

Type Name Position InterPro Accession
conserved_site Sugar transporter, conserved site 160 - 176 IPR005829
domain Major facilitator superfamily domain 88 - 514 IPR020846

Functions

Description
EC Number 1.1.1.30 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Mitochondrion inner membrane
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
matrix side of mitochondrial inner membrane The side (leaflet) of the mitochondrial inner membrane that faces the matrix.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

3 GO annotations of molecular function

Name Definition
3-hydroxybutyrate dehydrogenase activity Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
steroid dehydrogenase activity Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative.

1 GO annotations of biological process

Name Definition
steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8NEX9 SDR9C7 Short-chain dehydrogenase/reductase family 9C member 7 Homo sapiens (Human) PR
P80365 HSD11B2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens (Human) PR
O75452 RDH16 Retinol dehydrogenase 16 Homo sapiens (Human) PR
Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial Homo sapiens (Human) PR
Q9R092 Hsd17b6 17-beta-hydroxysteroid dehydrogenase type 6 Mus musculus (Mouse) PR
P50233 Hsd11b2 11-beta-hydroxysteroid dehydrogenase type 2 Rattus norvegicus (Rat) PR
O54753 Hsd17b6 17-beta-hydroxysteroid dehydrogenase type 6 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MLTARLSRPL SQLPRKTLNF SDRENGTRGS LLLYSAPFVP VGRRTYAASV DPVGSKAVLI
70 80 90 100 110 120
TGCDSGFGFS LAKHLHSEGF LVFAGCLMKD KGSDGVKELD SMKSDRLRTV QLNVCKSEEV
130 140 150 160 170 180
DKAAEVIRSS LEDPEKGLWG LVNNAGISTF GDVEFTSMET YKEVAEVNLW GTVRVTKAFL
190 200 210 220 230 240
PLIRRAKGRV VNISSMMGRM ANVARSPYCI TKFGVEAFSD CLRYEMHPLG VKVSVVEPGN
250 260 270 280 290 300
FIAATSLYGG TERIQAIANK MWEELPEVVR QDYGRKYFDE KVARMESYCT SGSTDTSPVI
310 320 330 340
KAVTHALTAT TPYTRYHPMD YYWWLRMQIM THFPGAISDR IYIH