AiPD: Autoinhibited Protein Database

Q9NRF8

Gene name	CTPS2
Protein name	CTP synthase 2
Names	CTP synthetase 2, UTP--ammonia ligase 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:56474
EC number	6.3.4.2: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

523-586 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

523-586 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

9 structures for Q9NRF8

Entry ID	Method	Resolution	Chain	Position	Source
2V4U	X-ray	230 A	A	297-562	PDB
2VKT	X-ray	250 A	A	297-562	PDB
3IHL	X-ray	280 A	A/B	1-275	PDB
6PK4	EM	350 A	A/B/C/D	1-586	PDB
6PK7	EM	310 A	A/D/E/F	1-586	PDB
7MH1	EM	280 A	H/J/K/L	1-586	PDB
7MIH	EM	280 A	A/B/C/E	1-586	PDB
7MII	EM	270 A	A/B/C/E	1-586	PDB
AF-Q9NRF8-F1	Predicted				AlphaFoldDB

214 variants for Q9NRF8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
COSM181857 CA10357180 rs200869248	7	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1417055959 CA412483131	7	T>S		No	ClinGen gnomAD
TCGA novel	10	V>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1412654809 CA412482928	23	I>T		No	ClinGen gnomAD
CA412482931 rs1569238969	23	I>V		No	ClinGen Ensembl
rs1483058889 CA412482905	25	T>K		No	ClinGen gnomAD
rs1483058889 CA412482907	25	T>M		No	ClinGen gnomAD
rs1261504476 CA412482848	30	C>R		No	ClinGen gnomAD
rs1008397802 CA327223208	32	L>V		No	ClinGen TOPMed
rs1306984433 CA412482813	33	R>Q		No	ClinGen gnomAD
CA412482788 rs1247361918	36	A>T		No	ClinGen gnomAD
rs964427569 CA327223207	37	I>V		No	ClinGen gnomAD
rs748681813 CA327223206	39	I>V		No	ClinGen Ensembl
rs751724576 CA10357175	45	I>V		No	ClinGen ExAC gnomAD
TCGA novel	48	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10357174 rs765136758	48	G>S		No	ClinGen ExAC gnomAD
CA327223205 rs955087690	56	G>S		No	ClinGen TOPMed gnomAD
rs781314454 CA10357159	60	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10357158 rs754997637	61	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	63	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	66	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA327222922 rs768255297	66	E>Q		No	ClinGen Ensembl
CA412482315 rs1172535458	70	D>E		No	ClinGen TOPMed gnomAD
CA412482325 rs1373730569	70	D>N		No	ClinGen gnomAD
rs758598445 CA10357155	76	R>I		No	ClinGen ExAC gnomAD
rs1200653545 CA412482194	79	D>G		No	ClinGen gnomAD
rs866455192 CA327222921	84	K>E		No	ClinGen Ensembl
CA412482123 rs1267457654	84	K>T		No	ClinGen gnomAD
CA412482091 rs1602286477	87	N>D		No	ClinGen Ensembl
rs753050665 CA10357154	89	T>S		No	ClinGen 1000Genomes ExAC gnomAD
rs139580060 CA10357153	90	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA412481996 rs752670958	99	N>D		No	ClinGen ExAC gnomAD
CA10357151 rs752670958	99	N>H		No	ClinGen ExAC gnomAD
rs767434269 CA10357150	103	R>C		No	ClinGen ExAC TOPMed gnomAD
CA10357149 rs146237387	103	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs61754548 CA327222919	110	T>I		No	ClinGen TOPMed
CA412481842 rs1460249681	110	T>S		No	ClinGen TOPMed
rs773609946 CA10357145	113	V>I		No	ClinGen ExAC gnomAD
rs1379491150 CA412481721	115	P>R		No	ClinGen TOPMed gnomAD
CA412481725 rs1304779733	115	P>S		No	ClinGen gnomAD
TCGA novel	117	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412481659 rs1444729762	120	A>S		No	ClinGen gnomAD
rs1444729762 CA412481662	120	A>T		No	ClinGen gnomAD
CA412481624 rs1337401193	123	E>Q		No	ClinGen gnomAD
CA10357130 rs759473259	127	N>S		No	ClinGen ExAC gnomAD
TCGA novel	131	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA327222873 rs946825746	132	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA327222872 rs867175690	133	V>M		No	ClinGen Ensembl
rs1172405945 CA412481512	135	G>S		No	ClinGen gnomAD
TCGA novel	136	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10357126 rs772839943	144	V>I		No	ClinGen ExAC gnomAD
CA327222502 rs867515916	153	D>N		No	ClinGen Ensembl
CA412480589 rs1252252843	156	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM122415 CA327222501 rs867125613	158	P>L	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1022482856 CA327222500	160	V>A		No	ClinGen TOPMed
rs1414875543 CA412480535	160	V>L		No	ClinGen gnomAD
TCGA novel	170	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10357104 rs764514112	170	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1293813244 CA412480305	171	K>R		No	ClinGen gnomAD
rs776075227 CA10357102	181	S>G		No	ClinGen ExAC gnomAD
rs745973464 CA10357100	183	V>I		No	ClinGen ExAC
rs193055681 CA327222494	187	S>N		No	ClinGen 1000Genomes TOPMed
rs1569233967 CA412479882	188	A>D		No	ClinGen Ensembl
CA327222493 rs200862252	190	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	191	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1289283772 CA412479616	198	Q>R		No	ClinGen gnomAD
rs753513954 CA10357086	199	N>S		No	ClinGen ExAC
CA10357083 rs141143406	201	V>A		No	ClinGen ESP ExAC TOPMed
CA10357084 rs761102007	201	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1291504955 CA412479550	202	R>C		No	ClinGen gnomAD
CA412479538 rs1276539401	203	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	205	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	208	G>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	213	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1602273252 CA412479134	214	I>T		No	ClinGen Ensembl
CA10357072 rs745800022	215	V>A		No	ClinGen ExAC gnomAD
TCGA novel	215	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10357071 rs778450479	217	R>Q		No	ClinGen ExAC gnomAD
rs1205396001 CA412479025	220	T>A		No	ClinGen gnomAD
rs371894543 CA10357070	220	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1057122282 CA327222380	221	P>H		No	ClinGen Ensembl
CA412478945 rs1198257633	225	A>S		No	ClinGen gnomAD
rs1217815741 CA412478752	234	C>S		No	ClinGen gnomAD
rs1367570893 CA412478740	234	C>S		No	ClinGen gnomAD
CA412478718 rs1455592938	236	V>M		No	ClinGen TOPMed
CA10357065 rs767967478	237	N>K		No	ClinGen ExAC TOPMed gnomAD
rs141929744 CA10357066	237	N>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA412478693 rs1383982088	238	P>S		No	ClinGen TOPMed
CA10357049 rs761532183	245	H>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	249	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412477693 rs1384594859	250	T>I		No	ClinGen gnomAD
TCGA novel	251	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10357047 rs755410764	253	V>I		No	ClinGen ExAC TOPMed gnomAD
rs758782939 CA10357044	262	I>V		No	ClinGen ExAC
CA327222226 rs974714943	263	V>E		No	ClinGen Ensembl
rs572560825 CA10357043	264	K>E		No	ClinGen 1000Genomes ExAC gnomAD
CA10357042 rs765226253	268	E>V		No	ClinGen ExAC gnomAD
CA10357041 rs148185373	270	L>F		No	ClinGen ESP ExAC gnomAD
CA10357039 rs764233202	275	G>S		No	ClinGen ExAC TOPMed gnomAD
rs759353943 CA10357038 COSM1190508	284	K>N	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel rs1602269556 CA412476965	286	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA Ensembl
TCGA novel	289	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1414814477 CA412475826	294	R>T		No	ClinGen TOPMed
CA327221355 rs1043071490	296	Q>E		No	ClinGen Ensembl
CA412475774 rs1474964640	297	K>N		No	ClinGen TOPMed
CA412475759 rs1196347111	298	I>M		No	ClinGen gnomAD
CA327221354 rs753016984	302	A>V		No	ClinGen Ensembl
TCGA novel	307	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	307	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1162566635 CA412475687	308	T>I		No	ClinGen TOPMed
TCGA novel	313	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412475609 rs148995160	315	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs148995160 CA10357021	315	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	318	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs370911868 CA10357020	325	A>S		No	ClinGen ESP ExAC gnomAD
rs760860238 CA10357019	328	I>V		No	ClinGen ExAC TOPMed gnomAD
rs766086337 CA10357017	330	H>R		No	ClinGen ExAC TOPMed gnomAD
rs945198414 CA327221353	331	K>R		No	ClinGen TOPMed
rs763009067 CA10357016	335	M>V		No	ClinGen ExAC gnomAD
CA10357002 rs374430696	342	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA327221015 rs983238790	344	K>N		No	ClinGen TOPMed
CA10357001 rs756391001	347	E>K		No	ClinGen ExAC TOPMed gnomAD
rs752853196 CA10357000	348	T>A		No	ClinGen ExAC TOPMed gnomAD
rs138897680 CA10356999	348	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs1333403911 COSM70334 CA412473655	349	E>K	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA412473621 rs1448165594	351	P>A		No	ClinGen TOPMed
CA412473625 rs1448165594	351	P>T		No	ClinGen TOPMed
rs1464284459 CA412473550	354	F>Y		No	ClinGen gnomAD
rs765111510 CA10356996	363	K>Q		No	ClinGen ExAC gnomAD
TCGA novel	366	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	366	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1312532570 CA412471051	369	V>M		No	ClinGen TOPMed
CA10356975 rs761910024	370	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1172314082 CA412470853	382	L>R		No	ClinGen gnomAD
rs369198202 CA10356974	383	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs764056005 CA412470824	384	A>E		No	ClinGen ExAC TOPMed gnomAD
CA327220314 rs1048600710	384	A>T		No	ClinGen TOPMed
rs764056005 CA10356973	384	A>V		No	ClinGen ExAC TOPMed gnomAD
CA327220313 rs765048544	386	S>T		No	ClinGen TOPMed gnomAD
CA412470720 rs1483736686	390	T>A		No	ClinGen TOPMed
CA10356971 rs775014073	391	K>R		No	ClinGen ExAC
CA412470679 rs1200073294	392	K>R		No	ClinGen TOPMed
rs896795921 CA327220312	393	I>V		No	ClinGen TOPMed
TCGA novel	396	L>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	398	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1260484642 CA412469791	400	L>P		No	ClinGen TOPMed
rs1164442212 CA412469768	402	M>L		No	ClinGen TOPMed gnomAD
CA10356959 rs775503464	403	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1185996624 CA412469707	405	A>V		No	ClinGen TOPMed
CA10356958 rs757122477	407	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1602230523 CA412469692	407	I>V		No	ClinGen Ensembl
CA412469609 rs1193718498	411	R>G		No	ClinGen gnomAD
CA327220067 rs939478017	418	D>G		No	ClinGen TOPMed gnomAD
CA10356945 rs776644709	422	T>I		No	ClinGen ExAC gnomAD
CA412469355 rs1289166065	424	F>L		No	ClinGen gnomAD
CA412469292 rs1199512153	428	A>V		No	ClinGen gnomAD
CA412468838 rs1347192731	439	H>R		No	ClinGen gnomAD
CA412468802 rs1274286121	440	N>S		No	ClinGen TOPMed
TCGA novel	442	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10356881 rs746750078	443	N>T		No	ClinGen ExAC gnomAD
rs775412284 CA10356880	444	L>V		No	ClinGen ExAC TOPMed gnomAD
CA10356877 rs778254775	448	M>I		No	ClinGen ExAC gnomAD
CA10356879 rs745431267	448	M>L		No	ClinGen ExAC TOPMed gnomAD
COSM181844 CA412468644 rs1191328413	448	M>T	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs745431267 CA10356878	448	M>V		No	ClinGen ExAC TOPMed gnomAD
CA412468503 rs1196744933	455	T>I		No	ClinGen TOPMed
rs146570387 CA10356876	458	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA327217533 rs762507057	463	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA412466980 rs1434120201	466	K>R		No	ClinGen TOPMed
rs1247194991 CA412466920	471	V>I		No	ClinGen gnomAD
rs372927744 CA10356822	472	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs367685844 CA10356821	473	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs769420240 CA10356820	474	I>V		No	ClinGen ExAC gnomAD
CA412466877 rs1362983617	475	E>K		No	ClinGen TOPMed gnomAD
rs1026552016 CA327216147	481	R>Q		No	ClinGen gnomAD
rs761440751 CA327215954	488	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	494	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763704576 CA10356800	495	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1247390464 CA412466212	495	N>S		No	ClinGen gnomAD
TCGA novel	496	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10356799 rs760369911	496	D>G		No	ClinGen ExAC gnomAD
CA412466185 rs1252610087	497	L>F		No	ClinGen gnomAD
rs1287342730 CA412466156	500	V>I		No	ClinGen TOPMed
CA10356798 rs775775118	503	D>N		No	ClinGen ExAC TOPMed gnomAD
rs772498309 COSM1118513 CA10356797	504	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs990756722 CA327215953	505	D>V		No	ClinGen TOPMed gnomAD
CA327215952 rs748507222	506	G>E		No	ClinGen Ensembl
rs1346300345 CA412466068	509	M>K		No	ClinGen gnomAD
TCGA novel	510	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA412466010 rs1369857948	512	I>T		No	ClinGen gnomAD
TCGA novel	515	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	517	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1165433047 CA412465182	518	P>L		No	ClinGen TOPMed
rs1278783605 CA412465114	525	F>L		No	ClinGen gnomAD
CA327215460 rs963600197	525	F>L		No	ClinGen TOPMed gnomAD
TCGA novel	527	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10356777 rs189978215	534	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs771465463 CA10356776	538	P>A		No	ClinGen ExAC gnomAD
CA412464933 rs1435639281	543	L>P		No	ClinGen TOPMed
TCGA novel	549	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10356772 rs748113836	556	Q>E		No	ClinGen ExAC gnomAD
rs1286171909 CA412464731	561	L>P		No	ClinGen gnomAD
rs1305835904 CA412464703	563	S>C		No	ClinGen gnomAD
CA327215457 rs374569479	564	S>G		No	ClinGen ESP TOPMed gnomAD
CA10356759 rs767206037	565	D>E		No	ClinGen ExAC TOPMed
TCGA novel	566	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10356758 rs759155589	567	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA412464614 rs1484614895	567	Y>H		No	ClinGen gnomAD
CA10356757 rs751985222	568	S>N		No	ClinGen ExAC gnomAD
CA412464570 rs1336463018	573	D>N		No	ClinGen gnomAD
rs1271079506 CA412464560	574	S>N		No	ClinGen gnomAD
rs766717924 CA10356756	575	F>L		No	ClinGen ExAC gnomAD
rs142220657 CA10356755	581	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs770159997 CA10356753	584	E>K		No	ClinGen ExAC gnomAD

No associated diseases with Q9NRF8

3 regional properties for Q9NRF8

Type	Name	Position	InterPro Accession
domain	CTP synthase, N-terminal	2 - 272	IPR017456
domain	Glutamine amidotransferase	310 - 543	IPR017926
domain	CTP synthase GATase domain	299 - 544	IPR033828

Functions

		Description
EC Number	6.3.4.2	Other carbon--nitrogen ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoophidium	A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CTP synthase activity	Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
identical protein binding	Binding to an identical protein or proteins.

5 GO annotations of biological process

Name	Definition
'de novo' CTP biosynthetic process	The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
CTP biosynthetic process	The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.
glutamine metabolic process	The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
pyrimidine nucleobase biosynthetic process	The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
pyrimidine nucleotide metabolic process	The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.

7 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q1RMS2	CTPS2	CTP synthase 2	Bos taurus (Bovine)	PR
Q5F3Z1	CTPS2	CTP synthase 2	Gallus gallus (Chicken)	PR
P17812	CTPS1	CTP synthase 1	Homo sapiens (Human)	PR
P70698	Ctps1	CTP synthase 1	Mus musculus (Mouse)	PR
P70303	Ctps2	CTP synthase 2	Mus musculus (Mouse)	PR
Q5U2N0	Ctps2	CTP synthase 2	Rattus norvegicus (Rat)	PR
Q6PEI7	ctps1	CTP synthase 1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MKYILVTGGV	ISGIGKGIIA	SSIGTILKSC	GLRVTAIKID	PYINIDAGTF	SPYEHGEVFV
70	80	90	100	110	120
LNDGGEVDLD	LGNYERFLDI	NLYKDNNITT	GKIYQHVINK	ERRGDYLGKT	VQVVPHITDA
130	140	150	160	170	180
VQEWVMNQAK	VPVDGNKEEP	QICVIELGGT	IGDIEGMPFV	EAFRQFQFKA	KRENFCNIHV
190	200	210	220	230	240
SLVPQLSATG	EQKTKPTQNS	VRALRGLGLS	PDLIVCRSST	PIEMAVKEKI	SMFCHVNPEQ
250	260	270	280	290	300
VICIHDVSST	YRVPVLLEEQ	SIVKYFKERL	HLPIGDSASN	LLFKWRNMAD	RYERLQKICS
310	320	330	340	350	360
IALVGKYTKL	RDCYASVFKA	LEHSALAINH	KLNLMYIDSI	DLEKITETED	PVKFHEAWQK
370	380	390	400	410	420
LCKADGILVP	GGFGIRGTLG	KLQAISWART	KKIPFLGVCL	GMQLAVIEFA	RNCLNLKDAD
430	440	450	460	470	480
STEFRPNAPV	PLVIDMPEHN	PGNLGGTMRL	GIRRTVFKTE	NSILRKLYGD	VPFIEERHRH
490	500	510	520	530	540
RFEVNPNLIK	QFEQNDLSFV	GQDVDGDRME	IIELANHPYF	VGVQFHPEFS	SRPMKPSPPY
550	560	570	580
LGLLLAATGN	LNAYLQQGCK	LSSSDRYSDA	SDDSFSEPRI	AELEIS