Q1RMS2
PR
Gene name |
CTPS2 |
Protein name |
CTP synthase 2 |
Names |
CTP synthetase 2, UTP--ammonia ligase 2 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:767849 |
EC number |
6.3.4.2: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q1RMS2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q1RMS2-F1 | Predicted | AlphaFoldDB |
91 variants for Q1RMS2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs450295585 | 15 | G>C | No | EVA | |
| rs454299390 | 42 | Y>D | No | EVA | |
| rs470314047 | 57 | E>* | No | EVA | |
| rs436742966 | 57 | E>V | No | EVA | |
| rs445644517 | 58 | V>G | No | EVA | |
| rs464201009 | 63 | D>A | No | EVA | |
| rs434514862 | 68 | D>E | No | EVA | |
| rs453021097 | 72 | G>V | No | EVA | |
| rs474844303 | 74 | Y>* | No | EVA | |
| rs435381031 | 77 | F>I | No | EVA | |
| rs457184447 | 80 | I>L | No | EVA | |
| rs475716180 | 82 | L>R | No | EVA | |
| rs443571882 | 85 | D>Y | No | EVA | |
| rs458979301 | 90 | T>S | No | EVA | |
| rs471059318 | 90 | T>S | No | EVA | |
| rs441342768 | 93 | I>T | No | EVA | |
| rs459777709 | 98 | I>T | No | EVA | |
| rs481376515 | 99 | N>K | No | EVA | |
| rs448605637 | 102 | R>G | No | EVA | |
| rs463862999 | 103 | R>G | No | EVA | |
| rs445574457 | 104 | G>C | No | EVA | |
| rs434474058 | 105 | D>V | No | EVA | |
| rs468277558 | 106 | Y>F | No | EVA | |
| rs446508745 | 106 | Y>H | No | EVA | |
| rs468277558 | 106 | Y>S | No | EVA | |
| rs435346437 | 110 | T>K | No | EVA | |
| rs469234336 | 111 | V>E | No | EVA | |
| rs457151622 | 111 | V>L | No | EVA | |
| rs433108783 | 112 | Q>K | No | EVA | |
| rs461776631 | 116 | H>P | No | EVA | |
| rs449009864 | 151 | I>M | No | EVA | |
| rs461050331 | 152 | G>V | No | EVA | |
| rs482752614 | 153 | D>A | No | EVA | |
| rs450856091 | 153 | D>E | No | EVA | |
| rs482752614 | 153 | D>V | No | EVA | |
| rs469400241 | 155 | E>K | No | EVA | |
| rs478350449 | 156 | G>E | No | EVA | |
| rs467077310 | 157 | M>R | No | EVA | |
| rs467077310 | 157 | M>T | No | EVA | |
| rs455951134 | 159 | F>L | No | EVA | |
| rs468048744 | 161 | E>V | No | EVA | |
| rs438322777 | 162 | A>E | No | EVA | |
| rs471324166 | 164 | R>S | No | EVA | |
| rs438393743 | 165 | Q>P | No | EVA | |
| rs453644457 | 166 | F>I | No | EVA | |
| rs472123925 | 167 | Q>P | No | EVA | |
| rs461017271 | 168 | F>S | No | EVA | |
| rs442553691 | 168 | F>V | No | EVA | |
| rs482960251 | 172 | R>* | No | EVA | |
| rs443545395 | 173 | E>D | No | EVA | |
| rs458852549 | 180 | V>F | No | EVA | |
| rs454574463 | 192 | Q>H | No | EVA | |
| rs443424017 | 195 | K>N | No | EVA | |
| rs438803632 | 209 | L>R | No | EVA | |
| rs442823634 | 232 | M>R | No | EVA | |
| rs433112979 | 243 | C>F | No | EVA | |
| rs445999532 | 260 | Q>H | No | EVA | |
| rs464442463 | 263 | I>F | No | EVA | |
| rs434752238 | 274 | I>S | No | EVA | |
| rs453247407 | 279 | S>C | No | EVA | |
| rs475127900 | 280 | S>R | No | EVA | |
| rs435759891 | 285 | W>C | No | EVA | |
| rs457497849 | 286 | R>S | No | EVA | |
| rs472162670 | 300 | S>C | No | EVA | |
| rs471754333 | 341 | D>E | No | EVA | |
| rs438842374 | 345 | T>I | No | EVA | |
| rs460610878 | 346 | T>P | No | EVA | |
| rs479189895 | 350 | D>A | No | EVA | |
| rs449383916 | 358 | W>L | No | EVA | |
| rs461600702 | 361 | L>I | No | EVA | |
| rs483268127 | 365 | D>G | No | EVA | |
| rs437305200 | 367 | V>D | No | EVA | |
| rs438617164 | 431 | P>R | No | EVA | |
| rs474057382 | 432 | V>M | No | EVA | |
| rs467215754 | 442 | G>S | No | EVA | |
| rs440760420 | 476 | E>G | No | EVA | |
| rs459456046 | 480 | H>P | No | EVA | |
| rs473175976 | 515 | A>V | No | EVA | |
| rs456351057 | 518 | P>R | No | EVA | |
| rs439554107 | 519 | Y>S | No | EVA | |
| rs458243248 | 521 | V>F | No | EVA | |
| rs479865630 | 531 | S>P | No | EVA | |
| rs440540510 | 535 | K>R | No | EVA | |
| rs462384488 | 546 | A>G | No | EVA | |
| rs451211932 | 555 | L>H | No | EVA | |
| rs480800639 | 555 | L>I | No | EVA | |
| rs469630514 | 558 | G>V | No | EVA | |
| rs477856430 | 564 | S>T | No | EVA | |
| rs456596517 | 574 | S>I | No | EVA | |
| rs465437181 | 577 | E>G | No | EVA | |
| rs465437181 | 577 | E>V | No | EVA |
No associated diseases with Q1RMS2
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.2 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoophidium | A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| CTP synthase activity | Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. |
| identical protein binding | Binding to an identical protein or proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. |
| CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. |
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
| pyrimidine nucleobase biosynthetic process | The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5F3Z1 | CTPS2 | CTP synthase 2 | Gallus gallus (Chicken) | PR |
| P17812 | CTPS1 | CTP synthase 1 | Homo sapiens (Human) | PR |
| Q9NRF8 | CTPS2 | CTP synthase 2 | Homo sapiens (Human) | PR |
| P70698 | Ctps1 | CTP synthase 1 | Mus musculus (Mouse) | PR |
| P70303 | Ctps2 | CTP synthase 2 | Mus musculus (Mouse) | PR |
| Q5U2N0 | Ctps2 | CTP synthase 2 | Rattus norvegicus (Rat) | PR |
| Q6PEI7 | ctps1 | CTP synthase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKYILVTGGV | ISGIGKGIIA | SSIGTILKSC | GLRVTAIKID | PYINIDAGTF | SPYEHGEVFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNDGGEVDLD | LGNYERFLDI | NLYKDNNITT | GKIYQHVINK | ERRGDYLGKT | VQVVPHITDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VQEWVMNQAM | VPVDGHKEEP | QICVIELGGT | IGDIEGMPFV | EAFRQFQFKA | KRENFCNIHV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLVPQPSATG | EQKTKPTQNS | VRALRGLGLS | PDLIVCRSST | PIEMAVKEKI | SMFCHVNPEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VICIHDVSST | YRVPVLLEEQ | GIIKYFKERL | DLPIGDSASS | LLSKWRNMAD | RYERLQKTCS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IALVGKYTKL | RDCYASVFKA | LEHSALAINH | KLNLMYIDSI | DLEQTTEVED | PVKFHEAWQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LCKADGVLVP | GGFGIRGTLG | KLQAISWARS | RKIPFLGVCL | GMQLAVIEFA | RNCLNLKDAD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| STEFEPNARV | PVVIDMPEHN | PGNLGGTMRL | GIRRTVFKTE | NSILRKLYGD | VPFIEERHRH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RYEVNPSLIS | QLEQKDLSFV | GQDVDGERME | IIELANHPYF | VGVQFHPEFS | SRPMKPSPPY |
| 550 | 560 | 570 | 580 | ||
| LGLLLAATGN | LNAYLLQGCK | LSSSDRYSDA | SDDSFSEPRL | AELEIS |