P70698
Gene name |
Ctps1 (Ctps) |
Protein name |
CTP synthase 1 |
Names |
CTP synthetase 1, UTP--ammonia ligase 1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:51797 |
EC number |
6.3.4.2: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P70698
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7MIP | EM | 240 A | C/D/G/I | 1-591 | PDB |
| AF-P70698-F1 | Predicted | AlphaFoldDB |
30 variants for P70698
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388706463 | 68 | D>N | No | EVA | |
| rs3388705982 | 83 | T>A | No | EVA | |
| rs3388710052 | 87 | N>Y | No | EVA | |
| rs3388707542 | 100 | K>* | No | EVA | |
| rs3388709744 | 152 | G>R | No | EVA | |
| rs3388696626 | 165 | Q>E | No | EVA | |
| rs3388709164 | 175 | F>L | No | EVA | |
| rs3388705959 | 205 | R>SE* | No | EVA | |
| rs3388712565 | 207 | L>V | No | EVA | |
| rs3394730261 | 256 | L>F | No | EVA | |
| rs3394772125 | 257 | L>F | No | EVA | |
| rs3394492970 | 258 | E>* | No | EVA | |
| rs3388708198 | 301 | I>F | No | EVA | |
| rs3388709746 | 306 | K>T | No | EVA | |
| rs3388709796 | 318 | I>T | No | EVA | |
| rs3388707570 | 333 | E>K | No | EVA | |
| rs3388706475 | 407 | V>S | No | EVA | |
| rs3388712538 | 408 | E>D | No | EVA | |
| rs3388708222 | 425 | D>G | No | EVA | |
| rs3388706439 | 457 | F>V | No | EVA | |
| rs3388703872 | 460 | K>R | No | EVA | |
| rs3394833764 | 463 | V>D | No | EVA | |
| rs3388714896 | 476 | E>G | No | EVA | |
| rs3394772249 | 499 | F>* | No | EVA | |
| rs3388703414 | 499 | F>L | No | EVA | |
| rs3388700583 | 512 | V>M | No | EVA | |
| rs13470396 | 515 | E>* | No | EVA | |
| rs3388710055 | 538 | P>T | No | EVA | |
| rs3388706450 | 544 | L>H | No | EVA | |
| rs3388700566 | 560 | R>L | No | EVA |
No associated diseases with P70698
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.2 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoophidium | A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| CTP synthase activity | Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. |
| identical protein binding | Binding to an identical protein or proteins. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. |
| B cell proliferation | The expansion of a B cell population by cell division. Follows B cell activation. |
| CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. |
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
| pyrimidine nucleobase biosynthetic process | The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. |
| T cell proliferation | The expansion of a T cell population by cell division. Follows T cell activation. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1RMS2 | CTPS2 | CTP synthase 2 | Bos taurus (Bovine) | PR |
| Q5F3Z1 | CTPS2 | CTP synthase 2 | Gallus gallus (Chicken) | PR |
| Q9NRF8 | CTPS2 | CTP synthase 2 | Homo sapiens (Human) | PR |
| P17812 | CTPS1 | CTP synthase 1 | Homo sapiens (Human) | PR |
| P70303 | Ctps2 | CTP synthase 2 | Mus musculus (Mouse) | PR |
| Q5U2N0 | Ctps2 | CTP synthase 2 | Rattus norvegicus (Rat) | PR |
| Q6PEI7 | ctps1 | CTP synthase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKYILVTGGV | ISGIGKGVIA | SSVGTILKSC | GLHVTSIKID | PYINIDAGTF | SPYEHGEVFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDDGGEVDLD | LGNYERFLDI | RLTKDNNLTT | GKIYQYVINK | ERKGDYLGKT | VQVVPHITDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQEWVMRQAL | IPVDEDGLEP | QVCVIELGGT | VGDIESMPFI | EAFRQFQFKV | KRENFCNIHV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLVPQPSSTG | EQKTKPTQNS | VRELRGLGLS | PDLVVCRCSN | PLDTSVKEKI | SMFCHVEPEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VICVHDVSSI | YRVPLLLEEQ | GVVDYFLRRL | DLPIERQSRK | MLMKWKEMAD | RYDRLLETCS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IALVGKYTKF | SDSYASVIKA | LEHSALAINH | KLEIKYIDST | DLEPSTLQEE | PVRYHEAWQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LCSAHGVLVP | GGFGVRGTEG | KIQAIAWARK | QKKPFLGVCL | GMQLAVVEFS | RNVLGWQDAN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| STEFDPKTSH | PVVIDMPEHN | PGQMGGTMRL | GKRRTLFQTK | NSVMRKLYGD | TDYLEERHRH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RFEVNPVLKK | CLEEQGLKFV | GQDVEGERME | IVELEDHPFF | VGVQYHPEFL | SRPIKPSPPY |
| 550 | 560 | 570 | 580 | 590 | |
| FGLLLASVGR | LPHYLQKGCR | LSPRDTYSDR | SGSSSPDSEI | TELKFPSISQ | D |