Q6PEI7
Gene name |
ctps1 (ctps1a, ctpsa) |
Protein name |
CTP synthase 1 |
Names |
CTP synthetase 1, UTP--ammonia ligase 1 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
|
EC number |
6.3.4.2: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6PEI7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6PEI7-F1 | Predicted | AlphaFoldDB |
No variants for Q6PEI7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6PEI7 | |||||
No associated diseases with Q6PEI7
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.2 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoophidium | A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| CTP synthase activity | Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. |
| identical protein binding | Binding to an identical protein or proteins. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. |
| CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. |
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
| notochord development | The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column. |
| pyrimidine nucleobase biosynthetic process | The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1RMS2 | CTPS2 | CTP synthase 2 | Bos taurus (Bovine) | PR |
| Q5F3Z1 | CTPS2 | CTP synthase 2 | Gallus gallus (Chicken) | PR |
| Q9NRF8 | CTPS2 | CTP synthase 2 | Homo sapiens (Human) | PR |
| P17812 | CTPS1 | CTP synthase 1 | Homo sapiens (Human) | PR |
| P70303 | Ctps2 | CTP synthase 2 | Mus musculus (Mouse) | PR |
| P70698 | Ctps1 | CTP synthase 1 | Mus musculus (Mouse) | PR |
| Q5U2N0 | Ctps2 | CTP synthase 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKYILVTGGV | ISGIGKGIIA | SSVGTILKSC | GLHVTAIKID | PYINIDAGTF | SPYEHGEVFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDDGGEVDLD | LGNYERFLDI | RLTKDNNLTT | GKIYQSVINK | ERRGDYLGKT | VQVVPHITDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQEWVMRQAK | IPVDDDDVEP | QVCVIELGGT | VGDIESMPFV | EAFRQFQFKV | KRENFCNIHV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLVPQPSATG | EQKTKPTQNS | VRELRGLGLS | PDLIMCRCST | PLDNSVKEKI | SMFCHVEPEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VICVHDVSSI | YRVPLLLEDQ | GVVGYFCRRL | NLPIENRPRK | MLAKWKEMSD | RSDRLLEQCS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IALVGKYTKF | SDSYASVIKA | LEHSALAISH | KLEVKYVDSA | DLEPSMLQEE | PVKYHEAWQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LCSSDGILVP | GGFGVRGTEG | KIQAINWARK | QKKPFLGVCL | GMQLAVCEFA | RNMLDWTDAN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| STEFDPETKH | PVVIDMPEHN | PGQMGGTMRL | GKRRTIFKNK | SSILRKLYGD | VDYVEERHRH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RFEVNPELKH | HFEEKGFRFV | GQDVEGERME | VIEMDDHPYF | VGVQYHPEFT | SRPIKPSPPY |
| 550 | 560 | 570 | 580 | 590 | |
| LGLLLAAAGR | LQSYLQKGCR | LSPRDAYSDR | SGSSSPDLEI | ADLKLRSIAQ | E |