P70303
Gene name |
Ctps2 |
Protein name |
CTP synthase 2 |
Names |
CTP synthetase 2, CTPsH, UTP--ammonia ligase 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:55936 |
EC number |
6.3.4.2: Other carbon--nitrogen ligases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P70303
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7MIU | EM | 260 A | C/D/G/H | 1-586 | PDB |
| 7MIV | EM | 280 A | C/D/G/H | 1-586 | PDB |
| AF-P70303-F1 | Predicted | AlphaFoldDB |
35 variants for P70303
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3412450990 | 65 | G>E | No | EVA | |
| rs3389582180 | 85 | D>G | No | EVA | |
| rs3389593217 | 109 | K>I | No | EVA | |
| rs3389585981 | 120 | A>T | No | EVA | |
| rs31369473 | 172 | K>R | No | EVA | |
| rs3412451015 | 180 | V>GLLTWR* | No | EVA | |
| rs3389560979 | 193 | K>T | No | EVA | |
| rs3412562962 | 223 | E>V | No | EVA | |
| rs3412137722 | 231 | S>P | No | EVA | |
| rs3412448564 | 247 | V>D | No | EVA | |
| rs3412653141 | 264 | K>* | No | EVA | |
| rs245842496 | 267 | Q>R | No | EVA | |
| rs3389560918 | 318 | F>L | No | EVA | |
| rs3389582664 | 320 | A>S | No | EVA | |
| rs3389560923 | 346 | T>I | No | EVA | |
| rs3412734883 | 388 | A>V | No | EVA | |
| rs31367730 | 393 | I>T | No | EVA | |
| rs3389593151 | 402 | M>K | No | EVA | |
| rs3412448540 | 404 | L>Q | No | EVA | |
| rs3412653258 | 409 | F>L | No | EVA | |
| rs3411265512 | 411 | R>N* | No | EVA | |
| rs3412358261 | 411 | R>T | No | EVA | |
| rs3412451089 | 415 | N>K | No | EVA | |
| rs3411265475 | 417 | K>Q | No | EVA | |
| rs3389575575 | 424 | F>I | No | EVA | |
| rs3389582128 | 427 | N>D | No | EVA | |
| rs3389533402 | 446 | G>E | No | EVA | |
| rs3389580791 | 475 | E>* | No | EVA | |
| rs3389491380 | 478 | H>Q | No | EVA | |
| rs3389550546 | 499 | F>I | No | EVA | |
| rs3389550556 | 506 | G>V | No | EVA | |
| rs3411267080 | 532 | R>M | No | EVA | |
| rs3389582242 | 532 | R>S | No | EVA | |
| rs3389574936 | 574 | S>R | No | EVA | |
| rs3389591563 | 576 | P>Q | No | EVA |
No associated diseases with P70303
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.4.2 | Other carbon--nitrogen ligases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoophidium | A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| CTP synthase activity | Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. |
| identical protein binding | Binding to an identical protein or proteins. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components. |
| CTP biosynthetic process | The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. |
| glutamine metabolic process | The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. |
| pyrimidine nucleobase biosynthetic process | The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1RMS2 | CTPS2 | CTP synthase 2 | Bos taurus (Bovine) | PR |
| Q5F3Z1 | CTPS2 | CTP synthase 2 | Gallus gallus (Chicken) | PR |
| P17812 | CTPS1 | CTP synthase 1 | Homo sapiens (Human) | PR |
| Q9NRF8 | CTPS2 | CTP synthase 2 | Homo sapiens (Human) | PR |
| P70698 | Ctps1 | CTP synthase 1 | Mus musculus (Mouse) | PR |
| Q5U2N0 | Ctps2 | CTP synthase 2 | Rattus norvegicus (Rat) | PR |
| Q6PEI7 | ctps1 | CTP synthase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKYILVTGGV | ISGIGKGIIA | SSIGTILKSC | GLRVTAIKID | PYINIDAGTF | SPYEHGEVFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNDGGEVDLD | LGNYERFLDI | NLYKDNNITT | GKIYQHVINK | ERRGDYLGKT | VQVVPHITDA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQEWVMNQAK | VSVDGNKEDP | QICVIELGGT | IGDIEGMAFV | EAFRQFQFKA | KKENFYNIHV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLVPQPSATG | EQKTKPTQNS | VRALRGLGLS | PDLIVCRSST | PIEMAVKEKI | SMFCHVNPEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VICIHDVSSI | YRVPLLLEEQ | GVVKYFQERL | GLPINDCSSN | LLFKWKAMAD | RYERLQKICS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IALVGKYTKL | RDCYASVFKA | LEHSALAINH | KLNLMYIDSI | DLEPVTKAED | PVKFHEAWQK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LCLADGILVP | GGFGIRGTLG | KLQAISWART | KKIPFLGICL | GMQLAVIEFA | RNCLNLKDAN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| STEFEPNTPV | PLVIDMPEHN | PGDLGGTMRL | GLRRTVFTTE | NSILKKLYGD | VPYIEERHRH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RYEVNPNLIN | QFENKDLCFV | GEDVDGKRME | IVELTSHPYF | IGVQFHPEFS | SRPMKPSPPY |
| 550 | 560 | 570 | 580 | ||
| LGLLLAATGN | LNAHLQQMNK | LPYSDGYSDA | SDDSFPEAKL | AELDLN |