Q5U2N0

PR
Gene name
Ctps2
Protein name
CTP synthase 2
Names
CTP synthetase 2, UTP--ammonia ligase 2
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:619580
EC number
6.3.4.2: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

519-586 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U2N0

Entry ID Method Resolution Chain Position Source
AF-Q5U2N0-F1 Predicted AlphaFoldDB

No variants for Q5U2N0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U2N0

No associated diseases with Q5U2N0

3 regional properties for Q5U2N0

Type Name Position InterPro Accession
domain CTP synthase, N-terminal 2 - 272 IPR017456
domain Glutamine amidotransferase 310 - 543 IPR017926
domain CTP synthase GATase domain 299 - 544 IPR033828

Functions

Description
EC Number 6.3.4.2 Other carbon--nitrogen ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoophidium A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CTP synthase activity Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
identical protein binding Binding to an identical protein or proteins.

4 GO annotations of biological process

Name Definition
'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q1RMS2 CTPS2 CTP synthase 2 Bos taurus (Bovine) PR
Q5F3Z1 CTPS2 CTP synthase 2 Gallus gallus (Chicken) PR
P17812 CTPS1 CTP synthase 1 Homo sapiens (Human) PR
Q9NRF8 CTPS2 CTP synthase 2 Homo sapiens (Human) PR
P70698 Ctps1 CTP synthase 1 Mus musculus (Mouse) PR
P70303 Ctps2 CTP synthase 2 Mus musculus (Mouse) PR
Q6PEI7 ctps1 CTP synthase 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MKYILVTGGV ISGIGKGIIA SSIGTILKSC GLRVTAIKID PYINIDAGTF SPYEHGEVFV
70 80 90 100 110 120
LNDGGEVDLD LGNYERFLDI NLYKDNNITT GKIYQHVINK ERRGDYLGKT VQVVPHITDA
130 140 150 160 170 180
IQDWVMNQAK VSVDGNKEDP QICVIELGGT IGDIEGMAFV EAFRQFQFKA KRENFYNIHV
190 200 210 220 230 240
SLVPQPSATG EQKTKPTQNS VRALRGLGLS PDLIVCRSST PIEMAVKEKI SMFCHVNPEQ
250 260 270 280 290 300
VICIHDVSSI YRVPLLLEEQ GVVKYFQERL DLPINDCSNN LLFKWKTMAD RYERLQKICS
310 320 330 340 350 360
IALVGKYTKL RDCYASVFKA LEHSALAINH KLNLMYIDSI DLEPVTKAED PVKFHEAWQK
370 380 390 400 410 420
LCLADGILVP GGFGIRGTLG KLQAISWART KKIPFLGICL GMQLAVIEFA RNCLNLKDAN
430 440 450 460 470 480
STEFDPNTPV PLVIDMPEHN PGDLGGTMRL GLRRTVFTTE NSILKKLYGD VPYIEERHRH
490 500 510 520 530 540
RYEVNPNLIN QFENKDLCFV GEDVDGKRME IIELTGHPYF IGVQFHPEFS SRPMKPSPPY
550 560 570 580
LGLLLAATGT LNTHLQQMSK LSYSDIYSDA SDDSFSEAKF AELDIN