Q9N1F5

PR
Gene name
GSTO1
Protein name
Glutathione S-transferase omega-1
Names
GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V) reductase, S-(Phenacyl)glutathione reductase, SPG-R
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397117
EC number
1.8.5.1: With a quinone or similar compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9N1F5

Entry ID Method Resolution Chain Position Source
AF-Q9N1F5-F1 Predicted AlphaFoldDB

6 variants for Q9N1F5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs702606246 4 G>E No EVA
rs337312060 120 S>F No EVA
rs331662197 141 G>S No EVA
rs80944846 165 F>L No EVA
rs710127605 228 L>I No EVA
rs694197151 233 S>I No EVA

No associated diseases with Q9N1F5

2 regional properties for Q9N1F5

Type Name Position InterPro Accession
domain GTP binding domain 112 - 227 IPR006073
domain EngB-type guanine nucleotide-binding (G) domain 109 - 282 IPR030393

Functions

Description
EC Number 1.8.5.1 With a quinone or similar compound as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
glutathione dehydrogenase (ascorbate) activity Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
methylarsonate reductase activity Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

4 GO annotations of biological process

Name Definition
cellular response to arsenic-containing substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
L-ascorbic acid metabolic process The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P78417 GSTO1 Glutathione S-transferase omega-1 Homo sapiens (Human) PR
O09131 Gsto1 Glutathione S-transferase omega-1 Mus musculus (Mouse) PR
Q9Z339 Gsto1 Glutathione S-transferase omega-1 Rattus norvegicus (Rat) PR
Q9FUS9 GSTU18 Glutathione S-transferase U18 Arabidopsis thaliana (Mouse-ear cress) PR
P46421 GSTU5 Glutathione S-transferase U5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZW30 GSTU1 Glutathione S-transferase U1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSGGSARSLG KGSAPPGPVP EGLIRVYSMR FCPFAQRTLL VLNAKGIRHQ VININLKNKP
70 80 90 100 110 120
EWFFQKNPSG LVPVLENSQG QLIYESAITC EYLDEAYPGK KLLPDDPYEK ACQKMVFELS
130 140 150 160 170 180
SKVPPLLIRF IRRENEADCS GLKEELRKEF SKLEEVLTKK KTTYFGGSSL SMIDYLIWPW
190 200 210 220 230 240
FERLEALELN ECIDHTPKLK LWMAAMMKDP AVSALHIEPR DLRAFNDLYL QNSPEACDYG
L