O09131

PR
Gene name
Gsto1 (Gstx, Gtsttl)
Protein name
Glutathione S-transferase omega-1
Names
GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V) reductase, S-(Phenacyl)glutathione reductase, SPG-R, p28
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:14873
EC number
1.8.5.1: With a quinone or similar compound as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-50 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O09131

Entry ID Method Resolution Chain Position Source
AF-O09131-F1 Predicted AlphaFoldDB

18 variants for O09131

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389547733 27 Y>N No EVA
rs3389549428 49 H>Q No EVA
rs3389557271 78 S>R No EVA
rs3389541174 90 C>Y No EVA
rs3389539301 101 K>N No EVA
rs3389549395 118 E>G No EVA
rs3389555928 136 K>N No EVA
rs8257574 140 P>L No EVA
rs37539749 141 N>D No EVA
rs8257575 143 R>K No EVA
rs252932606 148 N>K No EVA
rs221779206 150 F>L No EVA
rs8257609 204 A>T No EVA
rs3389512396 216 I>F No EVA
rs8257610 224 Y>F No EVA
rs3389512411 230 Q>H No EVA
rs259585888 238 Y>C No EVA
rs3389544808 240 L>F No EVA

No associated diseases with O09131

3 regional properties for O09131

Type Name Position InterPro Accession
domain Glutathione S-transferase, N-terminal 22 - 101 IPR004045
domain Glutathione S-transferase, C-terminal 129 - 208 IPR004046
domain Glutathione S-transferase, C-terminal-like 106 - 227 IPR010987

Functions

Description
EC Number 1.8.5.1 With a quinone or similar compound as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
basement membrane A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
myelin sheath An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.

4 GO annotations of molecular function

Name Definition
glutathione dehydrogenase (ascorbate) activity Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
glutathione transferase activity Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
methylarsonate reductase activity Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

8 GO annotations of biological process

Name Definition
cellular response to arsenic-containing substance Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
L-ascorbic acid biosynthetic process The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
L-ascorbic acid metabolic process The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.
negative regulation of ryanodine-sensitive calcium-release channel activity Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
positive regulation of ryanodine-sensitive calcium-release channel activity Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
xenobiotic catabolic process The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P78417 GSTO1 Glutathione S-transferase omega-1 Homo sapiens (Human) PR
Q9N1F5 GSTO1 Glutathione S-transferase omega-1 Sus scrofa (Pig) PR
Q9Z339 Gsto1 Glutathione S-transferase omega-1 Rattus norvegicus (Rat) PR
P46421 GSTU5 Glutathione S-transferase U5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FUS9 GSTU18 Glutathione S-transferase U18 Arabidopsis thaliana (Mouse-ear cress) PR
Q9ZW30 GSTU1 Glutathione S-transferase U1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSGESSRSLG KGSAPPGPVP EGQIRVYSMR FCPFAQRTLM VLKAKGIRHE VININLKNKP
70 80 90 100 110 120
EWFFEKNPLG LVPVLENSQG HLVTESVITC EYLDEAYPEK KLFPDDPYKK ARQKMTLESF
130 140 150 160 170 180
SKVPPLIASF VRSKRKEDSP NLREALENEF KKLEEGMDNY KSFLGGDSPS MVDYLTWPWF
190 200 210 220 230
QRLEALELKE CLAHTPKLKL WMAAMQQDPV ASSHKIDAKT YREYLNLYLQ DSPEACDYGL