P78417
PR
Gene name |
GSTO1 (GSTTLP28) |
Protein name |
Glutathione S-transferase omega-1 |
Names |
GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V) reductase, S-(Phenacyl)glutathione reductase, SPG-R |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:9446 |
EC number |
1.8.5.1: With a quinone or similar compound as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
18 structures for P78417
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1EEM | X-ray | 200 A | A | 1-241 | PDB |
| 3LFL | X-ray | 210 A | A/B/C | 1-241 | PDB |
| 3VLN | X-ray | 170 A | A | 1-241 | PDB |
| 4IS0 | X-ray | 172 A | A | 1-241 | PDB |
| 4YQM | X-ray | 238 A | A/B/C | 1-241 | PDB |
| 4YQU | X-ray | 194 A | A/B | 1-241 | PDB |
| 4YQV | X-ray | 206 A | A/B/C | 1-241 | PDB |
| 5UEH | X-ray | 200 A | A | 1-241 | PDB |
| 5V3Q | X-ray | 225 A | A | 1-241 | PDB |
| 5YVN | X-ray | 133 A | A | 1-241 | PDB |
| 5YVO | X-ray | 180 A | A | 1-241 | PDB |
| 6MHB | X-ray | 275 A | A/B/C/D/E/F | 1-241 | PDB |
| 6MHC | X-ray | 200 A | A/B | 1-241 | PDB |
| 6MHD | X-ray | 216 A | A/B | 1-241 | PDB |
| 6PNM | X-ray | 182 A | A | 2-241 | PDB |
| 6PNN | X-ray | 210 A | A | 2-241 | PDB |
| 6PNO | X-ray | 182 A | A | 2-241 | PDB |
| AF-P78417-F1 | Predicted | AlphaFoldDB |
202 variants for P78417
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1003018292 CA212447651 |
2 | S>C | No |
ClinGen TOPMed |
|
|
CA5681430 rs772396594 CA5681429 |
3 | G>R | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 4 | E>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA378076528 rs1474909556 |
6 | A>V | No |
ClinGen gnomAD |
|
|
RCV000969856 rs72559704 CA5681432 |
7 | R>K | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA378076533 rs72559704 |
7 | R>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1251385813 CA378076540 |
8 | S>T | No |
ClinGen TOPMed |
|
|
rs776806870 CA378076544 |
9 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760104472 CA5681434 |
10 | G>E | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 10 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs915721379 CA212447674 |
11 | K>R | No |
ClinGen gnomAD |
|
|
CA378076578 rs1258278989 |
12 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
rs752612056 CA5681464 |
13 | S>R | No |
ClinGen ExAC gnomAD |
|
|
rs777727184 CA5681466 |
15 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA378076599 rs1376725101 |
15 | P>S | No |
ClinGen gnomAD |
|
|
CA5681468 rs771344081 |
16 | P>L | No |
ClinGen ExAC gnomAD |
|
| rs1564835315 | 16 | P>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs370320075 CA212447958 |
16 | P>T | No |
ClinGen ESP TOPMed |
|
| TCGA novel | 17 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1288941028 CA378076651 |
18 | P>S | No |
ClinGen gnomAD |
|
|
CA5681470 rs746005024 |
19 | V>I | No |
ClinGen ExAC gnomAD |
|
|
CA378076681 rs1181667116 |
20 | P>A | No |
ClinGen gnomAD |
|
|
rs769727460 CA5681471 |
20 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769727460 CA5681472 |
20 | P>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5681473 rs149222313 |
22 | G>D | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA378076772 rs1470661480 |
25 | R>H | No |
ClinGen gnomAD |
|
|
CA5681475 rs564705573 |
26 | I>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA378076849 rs1364917793 |
29 | M>I | No |
ClinGen gnomAD |
|
|
CA5681477 rs146896093 |
29 | M>T | No |
ClinGen ESP ExAC gnomAD |
|
|
rs762154396 CA5681476 |
29 | M>V | No |
ClinGen ExAC |
|
|
rs45529437 CA5681479 |
32 | C>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs45529437 CA5681478 VAR_061231 |
32 | C>Y | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA5681481 rs752197685 |
33 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA5681480 rs764679950 |
33 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1336993429 CA378076916 |
34 | F>C | No |
ClinGen gnomAD |
|
|
rs1448603478 CA378076947 |
36 | E>K | No |
ClinGen TOPMed |
|
|
CA378076971 rs1388272778 |
37 | R>K | No |
ClinGen TOPMed |
|
|
CA5681483 rs764125468 |
38 | T>M | No |
ClinGen ExAC gnomAD |
|
|
CA5681484 rs751456497 |
39 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs751456497 CA378076995 |
39 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs978522988 CA212448014 |
39 | R>L | No |
ClinGen gnomAD |
|
|
CA5681486 rs781512367 |
41 | V>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA212448023 rs924378265 |
41 | V>I | No |
ClinGen Ensembl |
|
|
rs1564835405 CA378077056 |
44 | A>V | No |
ClinGen Ensembl |
|
|
rs780009826 CA5681489 |
45 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1415972337 CA378077070 |
45 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs780009826 CA378077059 |
45 | K>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1186845498 CA378077068 |
45 | K>R | No |
ClinGen gnomAD |
|
|
rs1295829625 CA378077098 |
48 | R>K | No |
ClinGen TOPMed |
|
|
CA5681516 rs747397917 |
49 | H>Q | No |
ClinGen ExAC |
|
|
CA378078074 rs1380325561 |
49 | H>R | No |
ClinGen gnomAD |
|
|
CA378078095 rs1297390928 |
52 | I>T | No |
ClinGen gnomAD |
|
|
rs769393338 CA5681517 |
53 | N>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769393338 CA378078102 |
53 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 54 | I>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA212450216 rs1042620356 |
55 | N>S | No |
ClinGen Ensembl |
|
|
rs1019133448 CA212450219 |
57 | K>E | No |
ClinGen TOPMed |
|
|
rs968020753 CA378078174 |
61 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA212450225 rs968020753 |
61 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1296328958 CA378078189 |
62 | W>G | No |
ClinGen TOPMed |
|
|
CA212450232 rs775258075 |
63 | F>L | No |
ClinGen ExAC TOPMed |
|
|
CA378078213 rs762588581 |
64 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs762588581 CA5681519 |
64 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA378078225 rs1589844717 |
65 | K>E | No |
ClinGen Ensembl |
|
|
rs763724479 CA5681520 |
67 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs867668983 CA212450239 |
68 | P>L | No |
ClinGen Ensembl |
|
|
rs1188685675 CA378078264 |
68 | P>S | No |
ClinGen gnomAD |
|
|
CA378078271 rs1589844728 |
69 | F>L | No |
ClinGen Ensembl |
|
|
CA212450243 rs1008689901 |
70 | G>A | No |
ClinGen Ensembl |
|
|
rs374294843 CA5681523 |
73 | P>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 74 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1337492547 CA378078343 |
76 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
CA378078410 rs1431116964 |
82 | L>V | No |
ClinGen TOPMed |
|
|
rs760498687 CA5681525 |
83 | I>M | No |
ClinGen ExAC gnomAD |
|
|
CA378078420 rs1173648582 |
83 | I>T | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs750251204 CA5681524 |
83 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs747444602 CA378078437 CA378078435 |
84 | Y>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM914534 CA5681527 rs754091728 |
85 | E>K | Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA |
|
rs11509436 CA212450257 VAR_029269 |
86 | S>C | No |
ClinGen UniProt TOPMed dbSNP gnomAD |
|
|
rs1385375315 CA378078468 |
87 | A>V | No |
ClinGen gnomAD |
|
|
CA212450261 rs1018697878 |
89 | T>I | No |
ClinGen Ensembl |
|
|
CA378078498 rs1589844800 |
90 | C>S | No |
ClinGen Ensembl |
|
|
CA378078547 rs1215096671 |
94 | D>A | No |
ClinGen TOPMed |
|
|
CA378078583 rs1373009716 |
97 | Y>* | No |
ClinGen gnomAD |
|
|
rs1301153852 CA378078575 |
97 | Y>H | No |
ClinGen TOPMed gnomAD |
|
|
CA378078573 rs1301153852 |
97 | Y>N | No |
ClinGen TOPMed gnomAD |
|
|
rs752711264 CA5681530 |
98 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs146967406 CA5681529 |
98 | P>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5681532 rs758896615 |
99 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1261738193 CA378078608 |
100 | K>R | No |
ClinGen gnomAD |
|
|
rs1212133493 CA378078626 |
101 | K>N | No |
ClinGen gnomAD |
|
|
CA378078622 rs1310487761 |
101 | K>R | No |
ClinGen TOPMed |
|
|
rs148006054 CA5681533 |
103 | L>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs141645977 CA5681535 |
104 | P>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 104 | P>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5681534 rs747379810 |
104 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs748966808 CA5681537 |
106 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748966808 CA378078668 |
106 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs150506133 CA5681540 |
107 | P>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5681539 rs150506133 |
107 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs569087890 CA5681541 |
108 | Y>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5681542 rs773171640 |
109 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs760491652 CA5681543 |
110 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA212450322 rs916334054 |
111 | A>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1564836628 CA378078784 |
116 | I>S | No |
ClinGen Ensembl |
|
|
CA378078782 rs1564836628 |
116 | I>T | No |
ClinGen Ensembl |
|
|
CA378078801 rs1371252485 |
118 | E>Q | No |
ClinGen gnomAD |
|
| TCGA novel | 119 | L>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA378078851 rs1307980105 |
122 | K>T | No |
ClinGen gnomAD |
|
|
CA378079330 rs1473004441 |
123 | V>M | No |
ClinGen gnomAD |
|
|
CA5681568 rs763042697 |
125 | S>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs557588649 CA5681569 |
125 | S>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA378079372 rs751531910 |
127 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5681571 rs751531910 |
127 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1374901912 CA378079398 |
129 | S>N | No |
ClinGen gnomAD |
|
|
rs1031409217 CA212451533 |
129 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA5681572 rs575960084 |
131 | I>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs139445649 CA5681574 |
133 | S>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs756524212 CA5681575 |
133 | S>R | No |
ClinGen ExAC gnomAD |
|
|
CA378079546 rs1346508228 |
137 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs780242946 CA5681577 |
137 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs955721136 CA212451545 |
139 | Y>C | No |
ClinGen Ensembl |
|
|
VAR_016811 rs4925 CA5681578 |
140 | A>D | allele GSTO1*C; no effect on protein stability [UniProt] | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
rs757930662 CA5681580 |
143 | K>E | No |
ClinGen ExAC |
|
| rs771562518 | 145 | E>missing | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs777343283 CA5681581 |
145 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA5681582 rs746500935 |
146 | F>L | No |
ClinGen ExAC gnomAD |
|
|
rs777056461 CA5681584 |
147 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs141387929 CA5681585 |
147 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs141387929 CA5681586 |
147 | R>P | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs777056461 CA5681583 |
147 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA378079710 rs775096136 |
148 | K>* | No |
ClinGen ExAC gnomAD |
|
|
CA5681587 rs775096136 |
148 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1394624522 CA378079732 |
149 | E>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA212451573 rs1005666879 |
149 | E>A | No |
ClinGen TOPMed |
|
|
CA378079789 rs1175535889 |
150 | F>C | No |
ClinGen gnomAD |
|
|
CA212451576 rs954444943 |
150 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA378079865 rs1318102193 |
153 | L>R | No |
ClinGen TOPMed |
|
|
rs869031575 CA918751490 |
155 | E>R | No |
ClinGen Ensembl |
|
| VAR_016813 | 155 | E>del | allele GSTO1*B; decreased protein stability [UniProt] | No | UniProt |
|
CA378080896 rs1171295245 |
158 | T>S | No |
ClinGen TOPMed |
|
|
rs775355821 COSM1178275 CA5681607 |
159 | N>D | prostate [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA378080905 rs1237962921 |
159 | N>S | No |
ClinGen gnomAD |
|
|
rs200745440 CA5681608 |
161 | K>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs369551343 CA5681609 |
162 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
RCV000888345 rs116993524 CA5681610 |
163 | T>I | No |
ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA378080946 rs116993524 |
163 | T>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 165 | F>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA378080994 rs1260244599 |
167 | G>D | No |
ClinGen TOPMed |
|
|
rs761270521 CA5681614 |
168 | N>K | No |
ClinGen ExAC gnomAD |
|
|
rs148403642 CA5681613 |
168 | N>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA212452887 rs376039597 |
170 | I>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA378081026 rs1165520884 |
170 | I>T | No |
ClinGen Ensembl |
|
|
rs376039597 COSM1627302 CA5681615 |
170 | I>V | liver [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs754290509 CA5681616 |
171 | S>Y | No |
ClinGen ExAC gnomAD |
|
|
rs1279898487 CA378081063 |
172 | M>I | No |
ClinGen TOPMed |
|
|
rs369692828 CA5681617 |
173 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5681619 rs751246906 |
175 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA5681621 rs780689474 |
176 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA378081145 rs780689474 |
176 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA5681622 rs749866804 |
178 | W>* | No |
ClinGen ExAC gnomAD |
|
|
rs201522765 CA5681623 |
179 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1292504288 CA378081284 |
183 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs779840419 CA5681624 |
183 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1235136197 CA378081334 |
186 | A>T | No |
ClinGen gnomAD |
|
|
rs1427312417 CA378081661 |
191 | E>D | No |
ClinGen gnomAD |
|
|
CA5681647 rs772481441 |
193 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs1172415741 CA378081721 |
195 | H>N | No |
ClinGen gnomAD |
|
|
rs560168668 CA5681649 |
197 | P>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs747154809 CA5681650 |
198 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1274976017 CA378081868 |
202 | W>G | No |
ClinGen TOPMed |
|
|
CA378081895 rs1233433012 |
203 | M>I | No |
ClinGen TOPMed |
|
|
CA5681651 rs770951049 |
205 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA212453414 rs532141559 |
206 | M>I | No |
ClinGen 1000Genomes |
|
|
CA378081933 rs1383952851 |
206 | M>V | No |
ClinGen gnomAD |
|
|
VAR_024484 rs11509438 CA5681652 |
208 | E>K | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA212453423 CA212453420 rs369926436 |
209 | D>E | No |
ClinGen TOPMed |
|
|
rs746372013 CA5681653 |
210 | P>S | No |
ClinGen ExAC |
|
|
CA5681655 rs770264722 |
211 | T>P | No |
ClinGen ExAC gnomAD |
|
|
rs1233688548 CA378082097 |
214 | A>P | No |
ClinGen TOPMed gnomAD |
|
|
CA378082095 rs1233688548 |
214 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA5681657 rs763287842 |
215 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA378082153 rs15032 |
217 | T>I | No |
ClinGen gnomAD |
|
|
CA212453444 rs15032 |
217 | T>N | No |
ClinGen gnomAD |
|
|
CA5681660 rs772817786 |
220 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs764766650 CA212453460 |
221 | D>N | No |
ClinGen Ensembl |
|
|
rs921626074 CA212453466 |
223 | Q>E | No |
ClinGen Ensembl |
|
|
rs1263505296 CA378082310 |
225 | F>I | No |
ClinGen gnomAD |
|
|
CA5681663 rs753323694 |
227 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
rs754940007 CA5681664 |
228 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs569003679 CA5681665 |
229 | Y>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs373305518 CA5681666 CA378082423 |
231 | Q>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1176324895 CA378082419 |
231 | Q>P | No |
ClinGen TOPMed gnomAD |
|
|
rs888045519 CA212453490 |
234 | P>S | No |
ClinGen Ensembl |
|
|
rs11509439 VAR_026583 CA5681668 |
236 | A>V | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA212453505 rs986118514 |
237 | C>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs747220782 CA5681669 |
238 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA378082477 rs1324025414 |
239 | Y>* | No |
ClinGen gnomAD |
|
|
rs148530043 CA5681670 |
239 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5681671 rs781132094 |
241 | L>F | No |
ClinGen ExAC gnomAD |
|
|
rs1220103732 CA378082492 |
242 | L>G | No |
ClinGen gnomAD |
|
|
rs548093642 CA5681672 |
242 | L>S | No |
ClinGen 1000Genomes ExAC gnomAD |
No associated diseases with P78417
Functions
| Description | ||
|---|---|---|
| EC Number | 1.8.5.1 | With a quinone or similar compound as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione dehydrogenase (ascorbate) activity | Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide. |
| glutathione transferase activity | Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. |
| methylarsonate reductase activity | Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid. |
| oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to arsenic-containing substance | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. |
| glutathione metabolic process | The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. |
| L-ascorbic acid metabolic process | The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. |
| negative regulation of ryanodine-sensitive calcium-release channel activity | Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
| positive regulation of ryanodine-sensitive calcium-release channel activity | Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts. |
| positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion | Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. |
| regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction. |
| regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. |
| xenobiotic catabolic process | The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O09131 | Gsto1 | Glutathione S-transferase omega-1 | Mus musculus (Mouse) | PR |
| Q9N1F5 | GSTO1 | Glutathione S-transferase omega-1 | Sus scrofa (Pig) | PR |
| Q9Z339 | Gsto1 | Glutathione S-transferase omega-1 | Rattus norvegicus (Rat) | PR |
| P46421 | GSTU5 | Glutathione S-transferase U5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FUS9 | GSTU18 | Glutathione S-transferase U18 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9ZW30 | GSTU1 | Glutathione S-transferase U1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGESARSLG | KGSAPPGPVP | EGSIRIYSMR | FCPFAERTRL | VLKAKGIRHE | VININLKNKP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EWFFKKNPFG | LVPVLENSQG | QLIYESAITC | EYLDEAYPGK | KLLPDDPYEK | ACQKMILELF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKVPSLVGSF | IRSQNKEDYA | GLKEEFRKEF | TKLEEVLTNK | KTTFFGGNSI | SMIDYLIWPW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FERLEAMKLN | ECVDHTPKLK | LWMAAMKEDP | TVSALLTSEK | DWQGFLELYL | QNSPEACDYG |
| L |