Q9M2E0

PR
Gene name
RH12 (At3g61240, T20K12.140)
Protein name
DEAD-box ATP-dependent RNA helicase 12
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G61240
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-150 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q9M2E0

Entry ID Method Resolution Chain Position Source
AF-Q9M2E0-F1 Predicted AlphaFoldDB

16 variants for Q9M2E0

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_3_22666617_C_A 10 P>T No 1000Genomes
ENSVATH14464766 16 R>C No 1000Genomes
tmp_3_22666642_C_G 18 A>G No 1000Genomes
ENSVATH06354175 20 P>S No 1000Genomes
ENSVATH14464767 26 Q>L No 1000Genomes
ENSVATH02533656 29 R>Q No 1000Genomes
ENSVATH14464768 29 R>W No 1000Genomes
ENSVATH06354176 40 V>A No 1000Genomes
ENSVATH06354177 65 Q>K No 1000Genomes
ENSVATH06354178 67 S>L No 1000Genomes
tmp_3_22666855_C_T 89 P>L No 1000Genomes
ENSVATH12866907 93 S>N No 1000Genomes
ENSVATH14464770 208 T>I No 1000Genomes
tmp_3_22667610_T_C 221 I>T No 1000Genomes
tmp_3_22668141_C_G 275 A>G No 1000Genomes
ENSVATH14464773 325 I>V No 1000Genomes

No associated diseases with Q9M2E0

2 regional properties for Q9M2E0

Type Name Position InterPro Accession
domain Peptidase family M60 domain 533 - 880 IPR031161
domain M60-like domain, N-terminal 518 - 623 IPR035423

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm, P-body
  • Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

5 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
P-body assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
stress granule assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39517 DHH1 ATP-dependent RNA helicase DHH1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q5ZKB9 DDX6 Probable ATP-dependent RNA helicase DDX6 Gallus gallus (Chicken) PR
P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 Homo sapiens (Human) PR
P54823 Ddx6 Probable ATP-dependent RNA helicase DDX6 Mus musculus (Mouse) PR
Q6H7S2 Os02g0641800 DEAD-box ATP-dependent RNA helicase 8 Oryza sativa subsp japonica (Rice) PR
Q7XMK8 Os04g0533000 DEAD-box ATP-dependent RNA helicase 6 Oryza sativa subsp japonica (Rice) PR
Q109G2 Os10g0503700 DEAD-box ATP-dependent RNA helicase 12 Oryza sativa subsp japonica (Rice) PR
Q8RXK6 RH8 DEAD-box ATP-dependent RNA helicase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q94BV4 RH6 DEAD-box ATP-dependent RNA helicase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q0IHV9 ddx6 Probable ATP-dependent RNA helicase ddx6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MNTNRGRYPP GVGTGRGAPP NPDYHQSYRQ QQPPQDQQYV QRGYSQNPQQ MQLQQQHQQQ
70 80 90 100 110 120
QQQQQWSRRP QLPGNASNAN EVVQQTTQPE ASSDANGQDW KATLRLPPPD TRYQTADVTA
130 140 150 160 170 180
TKGNEFEDYF LKRDLLKGIY EKGFEKPSPI QEESIPIALT GSDILARAKN GTGKTGAFCI
190 200 210 220 230 240
PVLEKIDPNN NVIQAMILVP TRELALQTSQ VCKELSKYLN IQVMVTTGGT SLRDDIMRLH
250 260 270 280 290 300
QPVHLLVGTP GRILDLTKKG VCVLKDCAML VMDEADKLLS AEFQPSLEEL IQFLPQNRQF
310 320 330 340 350 360
LMFSATFPVT VKAFKDRHLR KPYVINLMDQ LTLMGVTQYY AFVEERQKVH CLNTLFSKLQ
370 380 390 400 410 420
INQSIIFCNS VNRVELLAKK ITELGYSCFY IHAKMVQDHR NRVFHEFRNG ACRNLVCTDL
430 440 450 460 470 480
FTRGIDIQAV NVVINFDFPR TSESYLHRVG RSGRFGHLGL AVNLVTYEDR FKMYQTEQEL
490
GTEIKPIPSN IDQAIYCQ