Q0IHV9
PR
Gene name |
ddx6 |
Protein name |
Probable ATP-dependent RNA helicase ddx6 |
Names |
DEAD box protein 6 |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:780039 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0IHV9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0IHV9-F1 | Predicted | AlphaFoldDB |
No variants for Q0IHV9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q0IHV9 | |||||
No associated diseases with Q0IHV9
5 regional properties for Q0IHV9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 243 - 251 | IPR000629 |
| domain | Helicase, C-terminal | 307 - 467 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 120 - 285 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 114 - 311 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 95 - 123 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| miRNA-mediated gene silencing by inhibition of translation | An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. |
| negative regulation of translation | Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. |
| P-body assembly | The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| stress granule assembly | The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P39517 | DHH1 | ATP-dependent RNA helicase DHH1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q5ZKB9 | DDX6 | Probable ATP-dependent RNA helicase DDX6 | Gallus gallus (Chicken) | PR |
| P26196 | DDX6 | Probable ATP-dependent RNA helicase DDX6 | Homo sapiens (Human) | PR |
| P54823 | Ddx6 | Probable ATP-dependent RNA helicase DDX6 | Mus musculus (Mouse) | PR |
| Q109G2 | Os10g0503700 | DEAD-box ATP-dependent RNA helicase 12 | Oryza sativa subsp japonica (Rice) | PR |
| Q7XMK8 | Os04g0533000 | DEAD-box ATP-dependent RNA helicase 6 | Oryza sativa subsp japonica (Rice) | PR |
| Q6H7S2 | Os02g0641800 | DEAD-box ATP-dependent RNA helicase 8 | Oryza sativa subsp japonica (Rice) | PR |
| Q9M2E0 | RH12 | DEAD-box ATP-dependent RNA helicase 12 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94BV4 | RH6 | DEAD-box ATP-dependent RNA helicase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RXK6 | RH8 | DEAD-box ATP-dependent RNA helicase 8 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTARTENPV | LMGMSSQNGQ | LRGPLKPSAG | PGGGGTQTQQ | INQLKNASTI | NSGSQQQAQS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MSSVIKPGDD | WKKTLKLPPK | DLRIKTSDVT | STKGNEFEDY | CLKRELLMGI | FEMGWEKPSP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IQEESIPIAL | SGRDILARAK | NGTGKSGAYL | IPLLERLDLK | KDCIQAMVIV | PTRELALQVS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QICIQVSKHM | GGVKVMATTG | GTNLRDDIMR | LDDTVHVVIA | TPGRILDLIK | KGVAKVDHIQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MIVLDEADKL | LSQDFVQIME | DIIITLPKNR | QILLYSATFP | LSVQKFMTSH | LQKPYEINLM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EELTLKGVTQ | YYAYVTERQK | VHCLNTLFSR | LQINQSIIFC | NSSQRVELLA | KKISQLGYSC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FYIHAKMRQE | HRNRVFHDFR | NGLCRNLVCT | DLFTRGIDIQ | AVNVVINFDF | PKLAETYLHR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IGRSGRFGHL | GLAINLITYD | DRFNLKSIEE | QLGTEIKPIP | SSIDKSLYVA | EYHSESGEDK |
| P |