AiPD: Autoinhibited Protein Database

Gene name	RH8 (At4g00660, F6N23.6)
Protein name	DEAD-box ATP-dependent RNA helicase 8
Names
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G00660
EC number	3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-144 (Predicted disordered autoinhibitory region) PR

1-144 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8RXK6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_4_274648_G_A	4	R>Q	No	1000Genomes
ENSVATH06406404	23	N>S	No	1000Genomes
tmp_4_274722_G_C	29	G>R	No	1000Genomes
ENSVATH06406405	33	H>Q	No	1000Genomes
ENSVATH06406406	35	P>T	No	1000Genomes
tmp_4_274800_G_C	55	A>P	No	1000Genomes
ENSVATH06406409	61	Q>H	No	1000Genomes
ENSVATH06406410	63	Q>E	No	1000Genomes
tmp_4_274855_T_C	73	L>P	No	1000Genomes
ENSVATH06406411	76	G>S	No	1000Genomes
tmp_4_274878_G_A	81	G>S	No	1000Genomes
tmp_4_274894_A_G	86	D>G	No	1000Genomes
tmp_4_275129_G_C	110	R>T	No	1000Genomes
ENSVATH13863702	202	A>T	No	1000Genomes
tmp_4_275959_T_C	203	V>A	No	1000Genomes
tmp_4_276142_C_G	264	T>S	No	1000Genomes
ENSVATH06406457	296	H>N	No	1000Genomes
ENSVATH10472066	321	F>L	No	1000Genomes
ENSVATH10472067	341	K>R	No	1000Genomes
tmp_4_277099_A_T	448	N>I	No	1000Genomes
ENSVATH06406474	449	A>S	No	1000Genomes
ENSVATH06406479	459	S>T	No	1000Genomes
tmp_4_277424_A_G	502	I>V	No	1000Genomes

Type	Name	Position	InterPro Accession
conserved_site	ATP-dependent RNA helicase DEAD-box, conserved site	278 - 286	IPR000629
domain	Helicase, C-terminal	342 - 502	IPR001650
domain	DEAD/DEAH box helicase domain	156 - 320	IPR011545
domain	Helicase superfamily 1/2, ATP-binding domain	150 - 346	IPR014001
domain	RNA helicase, DEAD-box type, Q motif	131 - 159	IPR014014

		Description
EC Number	3.6.4.13	Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization	Cytoplasm, P-body	Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasmic stress granule	A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
P-body	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity	Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
mRNA binding	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity	Unwinding of an RNA helix, driven by ATP hydrolysis.

Name	Definition
modulation by virus of host process	The process in which a virus effects a change in the structure or processes of its host organism.
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
mRNA transport	The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
P-body assembly	The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
stress granule assembly	The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
viral process	A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P39517	DHH1	ATP-dependent RNA helicase DHH1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q5ZKB9	DDX6	Probable ATP-dependent RNA helicase DDX6	Gallus gallus (Chicken)	PR
P26196	DDX6	Probable ATP-dependent RNA helicase DDX6	Homo sapiens (Human)	PR
P54823	Ddx6	Probable ATP-dependent RNA helicase DDX6	Mus musculus (Mouse)	PR
Q109G2	Os10g0503700	DEAD-box ATP-dependent RNA helicase 12	Oryza sativa subsp japonica (Rice)	PR
Q7XMK8	Os04g0533000	DEAD-box ATP-dependent RNA helicase 6	Oryza sativa subsp japonica (Rice)	PR
Q6H7S2	Os02g0641800	DEAD-box ATP-dependent RNA helicase 8	Oryza sativa subsp japonica (Rice)	PR
Q94BV4	RH6	DEAD-box ATP-dependent RNA helicase 6	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M2E0	RH12	DEAD-box ATP-dependent RNA helicase 12	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0IHV9	ddx6	Probable ATP-dependent RNA helicase ddx6	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR