Q5ZKB9

PR
Gene name
DDX6 (RCJMB04_11n24)
Protein name
Probable ATP-dependent RNA helicase DDX6
Names
DEAD box protein 6
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:419783
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZKB9

Entry ID Method Resolution Chain Position Source
AF-Q5ZKB9-F1 Predicted AlphaFoldDB

No variants for Q5ZKB9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZKB9

No associated diseases with Q5ZKB9

5 regional properties for Q5ZKB9

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 244 - 252 IPR000629
domain Helicase, C-terminal 308 - 468 IPR001650
domain DEAD/DEAH box helicase domain 121 - 286 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 115 - 312 IPR014001
domain RNA helicase, DEAD-box type, Q motif 96 - 124 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm, P-body
  • Cytoplasm
  • Nucleus
  • Upon cellular stress, relocalizes to stress granules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic stress granule A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
miRNA-mediated gene silencing by inhibition of translation An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
P-body assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
stress granule assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.

10 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P39517 DHH1 ATP-dependent RNA helicase DHH1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 Homo sapiens (Human) PR
P54823 Ddx6 Probable ATP-dependent RNA helicase DDX6 Mus musculus (Mouse) PR
Q109G2 Os10g0503700 DEAD-box ATP-dependent RNA helicase 12 Oryza sativa subsp japonica (Rice) PR
Q7XMK8 Os04g0533000 DEAD-box ATP-dependent RNA helicase 6 Oryza sativa subsp japonica (Rice) PR
Q6H7S2 Os02g0641800 DEAD-box ATP-dependent RNA helicase 8 Oryza sativa subsp japonica (Rice) PR
Q8RXK6 RH8 DEAD-box ATP-dependent RNA helicase 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q94BV4 RH6 DEAD-box ATP-dependent RNA helicase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M2E0 RH12 DEAD-box ATP-dependent RNA helicase 12 Arabidopsis thaliana (Mouse-ear cress) PR
Q0IHV9 ddx6 Probable ATP-dependent RNA helicase ddx6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MSTARTENPV IMGLSSQNGQ LRGPVKPSGG PGGGGTQTQQ QMNQLKNANT INNGTQQQAQ
70 80 90 100 110 120
SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED YCLKRELLMG IFEMGWEKPS
130 140 150 160 170 180
PIQEESIPIA LSGRDILARA KNGTGKSGAY LIPLLERLDL KKDNIQAMVI VPTRELALQV
190 200 210 220 230 240
SQICIQVSKH MGGAKVMATT GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVEHV
250 260 270 280 290 300
QMIVLDEADK LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL
310 320 330 340 350 360
MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL AKKISQLGYS
370 380 390 400 410 420
CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI QAVNVVINFD FPKLAETYLH
430 440 450 460 470 480
RIGRSGRFGH LGLAINLITY DDRFNLKSIE EQLGTEIKPI PSNIDKSLYV AEYHSEPVED
EKQ