Q9JKF7
Gene name |
Mrpl39 |
Protein name |
39S ribosomal protein L39, mitochondrial |
Names |
Herpes virus entry mediator C, Herpesvirus entry mediator C, HveC, Nectin cell adhesion molecule 1, Poliovirus receptor-related protein 1, L39mt, MRP-L39 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:27393 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JKF7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JKF7-F1 | Predicted | AlphaFoldDB |
15 variants for Q9JKF7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389440405 | 50 | S>G | No | EVA | |
| rs3389433679 | 78 | M>V | No | EVA | |
| rs3389415940 | 93 | S>R | No | EVA | |
| rs3389417402 | 104 | L>F | No | EVA | |
| rs6405201 | 133 | K>R | No | EVA | |
| rs52007053 | 164 | V>L | No | EVA | |
| rs3389430198 | 169 | V>A | No | EVA | |
| rs3406617513 | 264 | P>T | No | EVA | |
| rs3407067790 | 266 | I>V | No | EVA | |
| rs3389421902 | 269 | T>R | No | EVA | |
| rs241825540 | 280 | V>A | No | EVA | |
| rs221754652 | 314 | V>L | No | EVA | |
| rs47474189 | 315 | E>G | No | EVA | |
| rs257037522 | 324 | D>N | No | EVA | |
| rs241352923 | 325 | E>D | No | EVA |
No associated diseases with Q9JKF7
1 regional properties for Q9JKF7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Conserved oligomeric Golgi complex, subunit 4 | 176 - 480 | IPR013167 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
| mitochondrial large ribosomal subunit | The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site). |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial genome maintenance | The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. |
| mitochondrial translation | The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QNM8 | TARS3 | Threonine--tRNA ligase 2, cytoplasmic | Bos taurus (Bovine) | PR |
| P26639 | TARS1 | Threonine--tRNA ligase 1, cytoplasmic | Homo sapiens (Human) | PR |
| Q9NYK5 | MRPL39 | 39S ribosomal protein L39, mitochondrial | Homo sapiens (Human) | PR |
| Q3UQ84 | Tars2 | Threonine--tRNA ligase, mitochondrial | Mus musculus (Mouse) | PR |
| Q9D0R2 | Tars1 | Threonine--tRNA ligase 1, cytoplasmic | Mus musculus (Mouse) | PR |
| Q68FW7 | Tars2 | Threonine--tRNA ligase, mitochondrial | Rattus norvegicus (Rat) | PR |
| Q8GZ45 | At1g17960 | Probable threonine--tRNA ligase, cytoplasmic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MATAVGRLVL | RRPGAGGGAR | WRFIATSPAA | ELSPTELTEM | RNDLFNREKS | RQLSLTPRTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIEVKHVGKT | DPGTVFVMNK | NISTPYSCAM | HLSEWYCSKS | ILALVDGQPW | DMYKPLTKSC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EIKFLTFKDP | DPKEVNKAYW | RSCAMMLGCV | IERAFKDDYV | VSLVRAPEVP | VIAGAFCYDV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TLDKRLDEWM | PTKENLRSFT | KDAHALIYRD | LPFETLDVDA | RVALEIFQHN | KYKVDFIEEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASQNPERIVK | LHRIGDFIDV | SEGPLIPRTS | VCFQYEVSAV | HNLNPSQPNL | IRRFQGLSLP |
| 310 | 320 | 330 | |||
| THLRAQFTIW | DKLVERSRKM | VTEDEVRQTE | NTESTQ |