Q3UQ84

PR
Gene name
Tars2 (Tarsl1)
Protein name
Threonine--tRNA ligase, mitochondrial
Names
Threonyl-tRNA synthetase, ThrRS, Threonyl-tRNA synthetase-like 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:71807
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

359-432 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q3UQ84

Entry ID Method Resolution Chain Position Source
AF-Q3UQ84-F1 Predicted AlphaFoldDB

48 variants for Q3UQ84

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388652541 11 G>R No EVA
rs3388645080 36 W>* No EVA
rs3388638942 65 A>T No EVA
rs3393398117 71 P>H No EVA
rs3388651796 73 G>C No EVA
rs3388649901 76 V>I No EVA
rs3388645087 88 L>Q No EVA
rs3388651649 102 A>D No EVA
rs33141404 118 T>R No EVA
rs3388638905 125 L>Q No EVA
rs3388630611 134 A>T No EVA
rs3388649881 135 V>L No EVA
rs3388649288 163 E>A No EVA
rs3388645083 166 F>L No EVA
rs3388646387 169 D>V No EVA
rs3393251128 171 F>C No EVA
rs228733212 277 T>A No EVA
rs3388644521 290 E>* No EVA
rs33138953 298 R>Q No EVA
rs238103334 301 A>E No EVA
rs3388641381 301 A>S No EVA
rs3388648944 328 F>C No EVA
rs3388650200 331 P>S No EVA
rs3388644593 376 Y>F No EVA
rs3388652560 380 M>I No EVA
rs3388649244 386 P>L No EVA
rs212086913 392 D>N No EVA
rs3388651659 420 M>I No EVA
rs3388637944 440 A>G No EVA
rs3388648865 456 L>M No EVA
rs3388630625 470 P>A No EVA
rs3388641334 471 H>L No EVA
rs3388649275 526 K>M No EVA
rs3388652621 543 P>H No EVA
rs3388637938 615 W>* No EVA
rs3388637949 615 W>* No EVA
rs3388652527 619 L>F No EVA
rs250983498 619 L>R No EVA
rs3388651683 621 V>M No EVA
rs3388649826 631 E>K No EVA
rs33136965 651 D>H No EVA
rs3388644426 659 S>I No EVA
rs3402727894 674 F>I No EVA
rs3388652539 681 Q>* No EVA
rs3388642581 690 T>A No EVA
rs214432069 700 D>G No EVA
rs3388652613 709 L>P No EVA
rs3388644522 721 E>V No EVA

No associated diseases with Q3UQ84

2 regional properties for Q3UQ84

Type Name Position InterPro Accession
domain GRAM domain 69 - 176 IPR004182
domain VASt domain 326 - 497 IPR031968

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

4 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein homodimerization activity Binding to an identical protein to form a homodimer.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P07236 MST1 Threonine--tRNA ligase, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A6QNM8 TARS3 Threonine--tRNA ligase 2, cytoplasmic Bos taurus (Bovine) PR
P26639 TARS1 Threonine--tRNA ligase 1, cytoplasmic Homo sapiens (Human) PR
Q9NYK5 MRPL39 39S ribosomal protein L39, mitochondrial Homo sapiens (Human) PR
Q9D0R2 Tars1 Threonine--tRNA ligase 1, cytoplasmic Mus musculus (Mouse) PR
Q9JKF7 Mrpl39 39S ribosomal protein L39, mitochondrial Mus musculus (Mouse) PR
Q68FW7 Tars2 Threonine--tRNA ligase, mitochondrial Rattus norvegicus (Rat) PR
Q8GZ45 At1g17960 Probable threonine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MGLCLRWRRL GFPLPEFRRC ELHTVREASA PTPPHWLAER FGLFEELWTA HVKKLASMTQ
70 80 90 100 110 120
KKARAIKISL PEGQKVDAVA WNTTPYQLAH QISVTLADTA VAAEVNGELY DLDRPLETDC
130 140 150 160 170 180
HLRFLTFDSP EGKAVFWHSS AHVLGAAAEQ QLGAVLCRGP STESGFYHDF FLGKERTVRS
190 200 210 220 230 240
AELPILERIC QELIAAAQPF RRLEASRDQL RQLFKDNHFK LHLIEEKVTG PTATVYGCGM
250 260 270 280 290 300
SVDLCRGPHL RHTGQIGALK LLTNSSALWR SLGAPETLQR VSGISFPKVE LLRNWEARRE
310 320 330 340 350 360
AAELRDHRRI GKEQELFFFH ELSPGSCFFL PRGTRVYNAL VAFIRAEYAR RGFSEVKTPT
370 380 390 400 410 420
LFSTKLWEQS GHWEHYRADM FSLKPPGTDG VDNSQSGHPA RCPKDTLALK PMNCPAHCLM
430 440 450 460 470 480
FAHRPRSWRE LPVRLADFGA LHRAEASGSL GGLTRLWRFQ QDDAHIFCAP HQLEAEIQGC
490 500 510 520 530 540
LDFLRCVYSV LGFSFHLALS TRPPGFLGEP RLWDQAEQVL QQALEKFGEP WDLNPGDGAF
550 560 570 580 590 600
YGPKIDVHLH DALGRPHQCG TIQLDFQLPL RFDLQYKGPA GTPECPVLIH RAVLGSVERL
610 620 630 640 650 660
LGVLAESCGG KWPLWLSPLQ VVVIPVRTEQ EEYARQVQQC LQAAGLVSDL DADSGLTLSR
670 680 690 700 710 720
RVRRAQLAHY NFQFVVGQRE QSQRTVNVRT RDNRQLGERD LAESVQRLLE LQNARVPNAE
EVF