Q8GZ45

PR
Gene name
At1g17960 (F2H15.18)
Protein name
Probable threonine--tRNA ligase, cytoplasmic
Names
Threonyl-tRNA synthetase, ThrRS
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G17960
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-81 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8GZ45

Entry ID Method Resolution Chain Position Source
AF-Q8GZ45-F1 Predicted AlphaFoldDB

46 variants for Q8GZ45

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_1_6183733_G_A 2 A>V No 1000Genomes
tmp_1_6183652_G_A 29 A>V No 1000Genomes
tmp_1_6183635_G_A 35 L>F No 1000Genomes
ENSVATH01066114 55 E>K No 1000Genomes
ENSVATH04594804 70 I>S No 1000Genomes
tmp_1_6183405_T_G 74 L>F No 1000Genomes
tmp_1_6183353_T_C 92 R>G No 1000Genomes
tmp_1_6183351_C_A 92 R>S No 1000Genomes
ENSVATH01066113 96 G>D No 1000Genomes
tmp_1_6183329_A_C,G 100 L>V No 1000Genomes
ENSVATH00030168 102 I>V No 1000Genomes
ENSVATH11438970 113 T>I No 1000Genomes
ENSVATH04594801 119 A>T No 1000Genomes
ENSVATH04594800 131 G>R No 1000Genomes
tmp_1_6183200_C_A 143 D>Y No 1000Genomes
tmp_1_6182980_G_C 166 I>M No 1000Genomes
ENSVATH11438966 174 M>K No 1000Genomes
tmp_1_6182559_C_G 207 C>S No 1000Genomes
tmp_1_6182437_C_T 218 G>S No 1000Genomes
ENSVATH04594792 228 R>K No 1000Genomes
ENSVATH01066105 234 Y>C No 1000Genomes
tmp_1_6182379_G_T 237 T>K No 1000Genomes
ENSVATH13917323 241 R>S No 1000Genomes
tmp_1_6182261_G_A 245 H>Y No 1000Genomes
tmp_1_6182250_A_T 248 D>E No 1000Genomes
tmp_1_6182252_C_T 248 D>N No 1000Genomes
tmp_1_6182216_C_T 260 E>K No 1000Genomes
tmp_1_6182204_C_T 264 D>N No 1000Genomes
tmp_1_6182189_G_T 269 P>T No 1000Genomes
tmp_1_6182075_A_T 280 Y>N No 1000Genomes
tmp_1_6182048_A_G 289 S>P No 1000Genomes
ENSVATH00030162 326 V>M No 1000Genomes
ENSVATH00030161 330 S>R Number of days following stratification to opening of first flower. the experiment was stopped at 200 d and accessions that had not flowered at that point were assigned a value of 200 [18c with 16 hrs daylight and vernalized (5 wks at 4c)] [EnsemblGenome] No 1000Genomes
tmp_1_6181781_T_C 347 Y>C No 1000Genomes
tmp_1_6181767_G_C 352 P>A No 1000Genomes
ENSVATH04594788 354 W>* No 1000Genomes
tmp_1_6181706_T_C 372 Y>C No 1000Genomes
ENSVATH00030158 383 V>A No 1000Genomes
ENSVATH04594784 398 K>E No 1000Genomes
ENSVATH04594784 398 K>Q No 1000Genomes
ENSVATH04594779 402 D>N No 1000Genomes
ENSVATH04594778 403 A>S No 1000Genomes
ENSVATH11438769 404 R>Q No 1000Genomes
tmp_1_6181236_G_A 420 A>V No 1000Genomes
ENSVATH00030157 424 V>M No 1000Genomes
ENSVATH04594775 437 D>N No 1000Genomes

No associated diseases with Q8GZ45

5 regional properties for Q8GZ45

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 168 - 347 IPR002314
domain TGS 41 - 104 IPR004095
domain Anticodon-binding 359 - 451 IPR004154
domain Aminoacyl-tRNA synthetase, class II 170 - 352 IPR006195
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 357 - 451 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QNM8 TARS3 Threonine--tRNA ligase 2, cytoplasmic Bos taurus (Bovine) PR
Q9NYK5 MRPL39 39S ribosomal protein L39, mitochondrial Homo sapiens (Human) PR
P26639 TARS1 Threonine--tRNA ligase 1, cytoplasmic Homo sapiens (Human) PR
Q9D0R2 Tars1 Threonine--tRNA ligase 1, cytoplasmic Mus musculus (Mouse) PR
Q3UQ84 Tars2 Threonine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
Q9JKF7 Mrpl39 39S ribosomal protein L39, mitochondrial Mus musculus (Mouse) PR
Q68FW7 Tars2 Threonine--tRNA ligase, mitochondrial Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MANNHHPKDE AYLSSVIPKR IRLFEEIQAE QLEQLQSRPH DPIKITLLPD GIEKEGRRWE
70 80 90 100 110 120
TSPMDIAVQI SKGLAKSALV SSVNHVLWDM NRPLEGDCSL EIFGFDSDQG RNTFWHSSAH
130 140 150 160 170 180
ILGQALEQEY GCKLCIGPCE PRDEGFYYDS LYYGELGLND NHFPNIEAKL PIRMAEFGVL
190 200 210 220 230 240
HRNEDSGALG GMTRVRRFVQ DDAHIFCRVD QVEEEVKGVL DFIDYVYRIF GFTYELTLST
250 260 270 280 290 300
RPKDHIGDLE TWAKAENDLE KALDDFGKPW VIKEGDGAFY GPKIDITVSD ARNRKFQCAT
310 320 330 340 350 360
IQLDFQLPAC FKLKYLSEKN EMEAPVMIHS AVLGSIERMF AILLEHYKGI WPFWLSPRQA
370 380 390 400 410 420
IVCSLSEDCS SYAKQVQKQI NEVGYYVDID ESDRSLRKKV ADARDAPYNY ILVVGQKEVA
430 440 450
TGQVTVRLRE DPEGRKDLPE MSIESLLDEF KFKTVNFL