Q68FW7
Gene name |
Tars2 (Tarsl1) |
Protein name |
Threonine--tRNA ligase, mitochondrial |
Names |
Threonyl-tRNA synthetase, ThrRS, Threonyl-tRNA synthetase-like 1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:310672 |
EC number |
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q68FW7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q68FW7-F1 | Predicted | AlphaFoldDB |
1 variants for Q68FW7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs199281165 | 143 | V>L | No | EVA |
No associated diseases with Q68FW7
7 regional properties for Q68FW7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) | 404 - 606 | IPR002314 |
| domain | TGS | 64 - 126 | IPR004095 |
| domain | Anticodon-binding | 620 - 710 | IPR004154 |
| domain | Aminoacyl-tRNA synthetase, class II | 333 - 613 | IPR006195 |
| domain | Threonyl/alanyl tRNA synthetase, SAD | 233 - 282 | IPR012947 |
| domain | Threonine-tRNA ligase catalytic core domain | 305 - 618 | IPR033728 |
| domain | Threonine-tRNA ligase, class IIa, anticodon-binding domain | 618 - 709 | IPR047246 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.3 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| aminoacyl-tRNA editing activity | The hydrolysis of an incorrectly aminoacylated tRNA. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| threonine-tRNA ligase activity | Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| threonyl-tRNA aminoacylation | The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07236 | MST1 | Threonine--tRNA ligase, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A6QNM8 | TARS3 | Threonine--tRNA ligase 2, cytoplasmic | Bos taurus (Bovine) | PR |
| Q9NYK5 | MRPL39 | 39S ribosomal protein L39, mitochondrial | Homo sapiens (Human) | PR |
| P26639 | TARS1 | Threonine--tRNA ligase 1, cytoplasmic | Homo sapiens (Human) | PR |
| Q9D0R2 | Tars1 | Threonine--tRNA ligase 1, cytoplasmic | Mus musculus (Mouse) | PR |
| Q9JKF7 | Mrpl39 | 39S ribosomal protein L39, mitochondrial | Mus musculus (Mouse) | PR |
| Q3UQ84 | Tars2 | Threonine--tRNA ligase, mitochondrial | Mus musculus (Mouse) | PR |
| Q8GZ45 | At1g17960 | Probable threonine--tRNA ligase, cytoplasmic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLCLRWRRL | GFPLPGFRRC | ELHTVREAPI | PTPPHWLAER | FGLFEELWTA | QVKRLASMTQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKARTIKISL | PEGQKVDAVA | WNTTPYQLAQ | QISSTLADTA | VAAEVNGELY | DLDRPLETDC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HLRFLTFDSP | EGKAVFWRSS | AHVLGAAAEQ | HLGAVLCRGP | STESGFYLDF | FLGKERTVRS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TELPTLERIC | QEIITAAQPF | RRLEASRGQL | RQLFKDNHFK | LHVIEEKVTG | TTATVYGCGM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVDLCQGPHL | RHTGQIGALK | LLTNSSALWR | SSEAPETLQR | VSGISFPKAE | LLRNWEARRE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EAELRDHRRI | GKEQELFFFH | ELSPGSCFFL | PRGTRIYNAL | VAFIRAEYAR | RGFSEVKTPT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LFSTKLWEQS | GHWEHYRAHM | FSLKPPGTDG | VDSSQSGHPA | RCPKDTLALK | PMNCPAHCLM |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FAHRPRSWRE | LPVRLADFGV | LHRAEASGSL | GGLTRLWRFQ | QDDAHIFCAP | SQLEAEIRGC |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LDFLRSVYSV | LGFSFHLALS | TRPPGFLGEP | HLWDQAEKVL | QQALEEFGEP | WNLNPGDGAF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| YGPKIDVHLH | DALGRPHQCG | TIQLDFQLPL | RFDLQYKGPA | GAPECPVLIH | RAVLGSVERL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LGVLAESCGG | RWPLWLSPFQ | VVVIPVRTEQ | EDYARQVQQC | LQAAGLVSDL | DADCGLTLSR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| RVRRAQLAHY | NFQFVVGQRE | QSQMSVNVRT | RDNRQLGERG | LAESVQRLLE | LQDARVPNAE |
| ELF |