AiPD: Autoinhibited Protein Database

Gene name	Tars1 (Tars)
Protein name	Threonine--tRNA ligase 1, cytoplasmic
Names	Threonine--tRNA ligase, cytoplasmic, Threonyl-tRNA synthetase, ThrRS, Threonyl-tRNA synthetase 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:110960
EC number	6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-55 (Predicted disordered autoinhibitory region) PR

1-55 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9D0R2-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3405743579	89	G>V	No	EVA
rs3405321941	90	K>R	No	EVA
rs46399461	137	T>M	No	EVA
rs3389275232	222	K>E	No	EVA
rs3389369315	283	Y>*	No	EVA
rs3405771773	286	G>C	No	EVA
rs3405528141	287	K>N	No	EVA
rs3389350819	300	S>T	No	EVA
rs3389348107	305	K>*	No	EVA
rs3389352290	310	W>R	No	EVA
rs3389305919	473	D>E	No	EVA
rs3389350809	473	D>Y	No	EVA
rs3389325082	487	S>R	No	EVA
rs3389334682	501	P>T	No	EVA
rs3389325117	526	G>D	No	EVA
rs47803216	571	N>S	No	EVA
rs3389315965	581	D>E	No	EVA
rs3389274439	615	L>F	No	EVA
rs3389349801	643	A>V	No	EVA
rs50862471	700	V>L	No	EVA
rs3389325130	707	L>M	No	EVA
rs31584944	713	T>M	No	EVA
rs3389274454	716	K>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	399 - 607	IPR002314
domain	TGS	78 - 142	IPR004095
domain	Anticodon-binding	619 - 709	IPR004154
domain	Aminoacyl-tRNA synthetase, class II	346 - 612	IPR006195
domain	Threonyl/alanyl tRNA synthetase, SAD	248 - 297	IPR012947
domain	Threonine-tRNA ligase catalytic core domain	320 - 617	IPR033728
domain	Threonine-tRNA ligase, class IIa, anticodon-binding domain	617 - 708	IPR047246

		Description
EC Number	6.1.1.3	Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding	Binding to an identical protein or proteins.
threonine-tRNA ligase activity	Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
threonyl-tRNA aminoacylation	The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P07236	MST1	Threonine--tRNA ligase, mitochondrial	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
A6QNM8	TARS3	Threonine--tRNA ligase 2, cytoplasmic	Bos taurus (Bovine)	PR
Q9NYK5	MRPL39	39S ribosomal protein L39, mitochondrial	Homo sapiens (Human)	PR
P26639	TARS1	Threonine--tRNA ligase 1, cytoplasmic	Homo sapiens (Human)	PR
Q3UQ84	Tars2	Threonine--tRNA ligase, mitochondrial	Mus musculus (Mouse)	PR
Q9JKF7	Mrpl39	39S ribosomal protein L39, mitochondrial	Mus musculus (Mouse)	PR
Q68FW7	Tars2	Threonine--tRNA ligase, mitochondrial	Rattus norvegicus (Rat)	PR
Q8GZ45	At1g17960	Probable threonine--tRNA ligase, cytoplasmic	Arabidopsis thaliana (Mouse-ear cress)	PR