A6QNM8

PR
Gene name
TARS3 (TARSL2)
Protein name
Threonine--tRNA ligase 2, cytoplasmic
Names
Threonyl-tRNA synthetase, ThrRS, Threonyl-tRNA synthetase protein 3
Species
Bos taurus (Bovine)
KEGG Pathway
bta:525350
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

54-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QNM8

Entry ID Method Resolution Chain Position Source
AF-A6QNM8-F1 Predicted AlphaFoldDB

121 variants for A6QNM8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs458792797 8 A>G No EVA
rs470949809 9 E>G No EVA
rs135287859 10 A>G No EVA
rs136370737 11 V>G No EVA
rs459376749 12 A>G No EVA
rs459376749 12 A>V No EVA
rs481164120 13 S>A No EVA
rs481164120 13 S>P No EVA
rs133658066 14 R>C No EVA
rs133658066 14 R>G No EVA
rs463306817 15 L>P No EVA
rs134985935 17 R>G No EVA
rs450205068 18 Q>E No EVA
rs136054919 18 Q>R No EVA
rs465611513 19 E>G No EVA
rs432712478 20 E>G No EVA
rs432712478 20 E>V No EVA
rs466152301 21 D>E No EVA
rs447566773 21 D>G No EVA
rs436402075 22 I>L No EVA
rs454984911 22 I>N No EVA
rs436980910 23 R>P No EVA
rs470852139 25 L>P No EVA
rs441131056 28 E>G No EVA
rs459601419 29 V>D No EVA
rs459601419 29 V>G No EVA
rs474593442 30 H>Q No EVA
rs481763029 34 D>E No EVA
rs463245368 34 D>G No EVA
rs450188974 37 L>R No EVA
rs477739343 38 N>K No EVA
rs459170401 38 N>S No EVA
rs466431283 39 A>E No EVA
rs447934657 39 A>S No EVA
rs481374885 40 P>A No EVA
rs481374885 40 P>S No EVA
rs437324757 41 D>E No EVA
rs470278709 41 D>G No EVA
rs434599235 46 E>D No EVA
rs453133573 48 P>A No EVA
rs453133573 48 P>T No EVA
rs474917020 49 C>G No EVA
rs441554161 51 T>A No EVA
rs475284241 57 L>P No EVA
rs457789803 61 N>H No EVA
rs477592877 61 N>T No EVA
rs441401666 63 E>D No EVA
rs460042434 66 H>L No EVA
rs460042434 66 H>P No EVA
rs448472684 68 L>M No EVA
rs136962415 74 C>G No EVA
rs134881633 74 C>W No EVA
rs464626001 85 L>P No EVA
rs464626001 85 L>R No EVA
rs526603703 93 A>V No EVA
rs434537496 95 R>G No EVA
rs453069800 97 A>G No EVA
rs456756729 99 G>D No EVA
rs435483402 99 G>R No EVA
rs451343596 100 A>E No EVA
rs439189435 100 A>T No EVA
rs467561871 102 P>T No EVA
rs110096592 108 L>P No EVA
rs472356758 127 N>T No EVA
rs442646210 170 V>G No EVA
rs461203785 175 W>L No EVA
rs474295084 195 V>M No EVA
rs438056367 216 V>G No EVA
rs456600387 218 L>R No EVA
rs438625733 220 T>P No EVA
rs472530914 222 E>G No EVA
rs460424450 222 E>Q No EVA
rs442420636 224 E>D No EVA
rs434982618 229 V>G No EVA
rs453529015 231 W>S No EVA
rs475386956 232 H>P No EVA
rs475627411 236 H>P No EVA
rs458083308 238 L>P No EVA
rs458083308 238 L>R No EVA
rs440203605 239 G>W No EVA
rs450712307 243 E>D No EVA
rs480584450 243 E>G No EVA
rs462520801 245 H>Y No EVA
rs444906291 248 G>A No EVA
rs434970028 253 S>R No EVA
rs447064936 254 P>A No EVA
rs462341041 256 G>V No EVA
rs457587802 257 D>A No EVA
rs475563909 261 H>N No EVA
rs464005637 271 V>M No EVA
rs434417702 274 A>P No EVA
rs452984964 277 P>L No EVA
rs443054263 279 L>R No EVA
rs455142733 281 S>I No EVA
rs476928550 289 E>* No EVA
rs443630843 297 E>V No EVA
rs477422214 305 D>H No EVA
rs459887260 307 F>L No EVA
rs441250219 307 F>S No EVA
rs442020859 313 K>E No EVA
rs463695540 322 A>P No EVA
rs525877410 355 F>L No EVA
rs722861503 363 A>V No EVA
rs477242495 397 A>G No EVA
rs447476370 401 R>S No EVA
rs379273210 408 E>D No EVA
rs797748311 459 L>V No EVA
rs383158744 460 W>L No EVA
rs437910703 513 D>A No EVA
rs456038350 519 R>G No EVA
rs443080036 519 R>S No EVA
rs471405630 522 P>Q No EVA
rs438441459 524 G>R No EVA
rs473402558 528 G>S No EVA
rs440594065 530 T>A No EVA
rs462266903 531 C>F No EVA
rs480690355 532 V>G No EVA
rs444753749 538 D>G No EVA
rs462864227 546 V>G No EVA
rs109405048 626 K>E No EVA
rs443464097 716 E>* No EVA

No associated diseases with A6QNM8

3 regional properties for A6QNM8

Type Name Position InterPro Accession
domain CSC1/OSCA1-like, 7TM region 374 - 646 IPR003864
domain CSC1/OSCA1-like, cytosolic domain 201 - 363 IPR027815
domain CSC1/OSCA1-like, N-terminal transmembrane domain 7 - 180 IPR032880

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Primarily cytoplasmic
  • Also detected at lower levels in the nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P07236 MST1 Threonine--tRNA ligase, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P26639 TARS1 Threonine--tRNA ligase 1, cytoplasmic Homo sapiens (Human) PR
Q9NYK5 MRPL39 39S ribosomal protein L39, mitochondrial Homo sapiens (Human) PR
Q3UQ84 Tars2 Threonine--tRNA ligase, mitochondrial Mus musculus (Mouse) PR
Q9D0R2 Tars1 Threonine--tRNA ligase 1, cytoplasmic Mus musculus (Mouse) PR
Q9JKF7 Mrpl39 39S ribosomal protein L39, mitochondrial Mus musculus (Mouse) PR
Q68FW7 Tars2 Threonine--tRNA ligase, mitochondrial Rattus norvegicus (Rat) PR
Q8GZ45 At1g17960 Probable threonine--tRNA ligase, cytoplasmic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAAEALAAEA VASRLARQEE DIRWLWAEVH RLRDEQLNAP DRCQAEGPCL TREVAQLRAE
70 80 90 100 110 120
NRELRHCLYR LRLCLAEELS HQARLESAAR AEAGRAAAGA QPPPSQSLEE DVKKEIDPDN
130 140 150 160 170 180
EVKNPPNFMK ERLKFFEILK KDHQLLLAIY EKKGDSSNVI TVRVADGRTV KGEAWKTTPY
190 200 210 220 230 240
QVAAEISQEL AETTVVAKVN GELWDLDRPL EGDATVELLT FEDEEARAVY WHSSAHVLGE
250 260 270 280 290 300
ALELHYGGLL CCSPPGDGSF HYDVYLEDRA VSSAELPVLE SMCQAIIKEQ QPFERLEVST
310 320 330 340 350 360
KVLLDLFKYN KFKCRILKEK VATPTTTVYR CGPLVELCKG PHVRHTGTIK VIKIFKNSLA
370 380 390 400 410 420
YWADNPEMEM LQRVYGVSFP DEQRMAAWEE LQEEARARDH RTIGKEQELF FFHDLSPGSC
430 440 450 460 470 480
FFLPRGACIY NTLIDFIREQ HHQRNFTEVL SPNMYSCKLW EASGHWQHYS ENMFTFDIDK
490 500 510 520 530 540
DTFALKPMNC PGHCLMFAHR PRSWREMPIR LADFGVLHRN EPSGALSGLT CVRRFQQDDA
550 560 570 580 590 600
HIFCTVGQLE EEIKGCLQFL QSVYSTFGFS FQLNLSTRPE NFLGKIELWD EAEKQLQNSL
610 620 630 640 650 660
MEFGKPWKIN PGEGAFYGPK IDLEIKDALG RYHQCATIQL DFQLPIRFNL TYVSKDGDDK
670 680 690 700 710 720
KNPVIIHQAI LGSVERMIAI LSENYGGKWP FWLSPRQVMV IPVGPTCEKY ALQWLEKRKR
QIML