Q9JK92
Gene name |
Hspb8 (Cryac, Hsp22) |
Protein name |
Heat shock protein beta-8 |
Names |
HspB8, Alpha-crystallin C chain, Small stress protein-like protein HSP22 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:80888 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9JK92
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9JK92-F1 | Predicted | AlphaFoldDB |
2 variants for Q9JK92
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3396214180 | 29 | R>H | No | EVA | |
| rs215499432 | 42 | D>E | No | EVA |
No associated diseases with Q9JK92
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| chaperone complex | A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to unfolded protein | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus. |
| positive regulation of aggrephagy | Any process that activates or increases the frequency, rate or extent of aggrephagy. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8MJ36 | HSPB8 | Heat shock protein beta-8 | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| P02518 | Hsp27 | Heat shock protein 27 | Drosophila melanogaster (Fruit fly) | PR |
| P02511 | CRYAB | Alpha-crystallin B chain | Homo sapiens (Human) | PR |
| Q9UJY1 | HSPB8 | Heat shock protein beta-8 | Homo sapiens (Human) | PR |
| Q9EPX0 | Hspb8 | Heat shock protein beta-8 | Rattus norvegicus (Rat) | PR |
| Q20363 | sip-1 | Stress-induced protein 1 | Caenorhabditis elegans | PR |
| A5JV83 | hspb11 | Heat shock protein beta-11 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADGQLPFPC | SYPSRLRRDP | FRDSPLSSRL | LDDGFGMDPF | PDDLTAPWPE | WALPRLSSAW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGTLRSGMVP | RGPPATARFG | VPAEGRSPPP | FPGEPWKVCV | NVHSFKPEEL | MVKTKDGYVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VSGKHEEKQQ | EGGIVSKNFT | KKIQLPAEVD | PATVFASLSP | EGLLIIEAPQ | VPPYSPFGES |
| 190 | |||||
| SFNNELPQDN | QEVTCS |