Q20363
Gene name |
sip-1 |
Protein name |
Stress-induced protein 1 |
Names |
|
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F43D9.4 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for Q20363
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4YDZ | X-ray | 360 A | A/B/C/D | 1-159 | PDB |
| 4YE0 | X-ray | 210 A | A/B | 43-159 | PDB |
| AF-Q20363-F1 | Predicted | AlphaFoldDB |
No variants for Q20363
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q20363 | |||||
No associated diseases with Q20363
1 regional properties for Q20363
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase M28 | 177 - 353 | IPR007484 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| unfolded protein binding | Binding to an unfolded protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| determination of adult lifespan | The pathways that regulate the duration of the adult phase of the life-cycle of an animal. |
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| protein metabolic process | The chemical reactions and pathways involving a protein. Includes protein modification. |
| protein refolding | The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P02518 | Hsp27 | Heat shock protein 27 | Drosophila melanogaster (Fruit fly) | PR |
| Q9UJY1 | HSPB8 | Heat shock protein beta-8 | Homo sapiens (Human) | PR |
| P02511 | CRYAB | Alpha-crystallin B chain | Homo sapiens (Human) | PR |
| Q9JK92 | Hspb8 | Heat shock protein beta-8 | Mus musculus (Mouse) | PR |
| Q9EPX0 | Hspb8 | Heat shock protein beta-8 | Rattus norvegicus (Rat) | PR |
| A5JV83 | hspb11 | Heat shock protein beta-11 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSLCPYTGR | PTGLFRDFED | MMPYWAQRHS | MLNNFNNIVP | QQLNEVENTA | QKFCVKLDVA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AFKPEELKVN | LEGHVLTIEG | HHEVKTEHGF | SKRSFTRQFT | LPKDVDLAHI | HTVINKEGQM |
| 130 | 140 | 150 | |||
| TIDAPKTGSN | TTVRALPIHT | SAGHAVTQKP | SSTTTTGKH |