Q9FFI2
Gene name |
ATG5 |
Protein name |
Autophagy protein 5 |
Names |
Protein autophagy 5, AtAPG5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G17290 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9FFI2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9FFI2-F1 | Predicted | AlphaFoldDB |
31 variants for Q9FFI2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_5689721_G_A | 34 | A>V | No | 1000Genomes | |
| ENSVATH10804601 | 39 | P>T | No | 1000Genomes | |
| ENSVATH14061295 | 99 | T>K | No | 1000Genomes | |
| ENSVATH06981116 | 101 | H>Y | No | 1000Genomes | |
| ENSVATH00627037 | 107 | C>S | No | 1000Genomes | |
| ENSVATH06981115 | 117 | D>N | No | 1000Genomes | |
| tmp_5_5688873_G_A | 118 | S>F | No | 1000Genomes | |
| tmp_5_5688422_T_G | 134 | I>L | No | 1000Genomes | |
| tmp_5_5688123_C_G | 160 | D>H | No | 1000Genomes | |
| tmp_5_5688119_A_G | 161 | L>P | No | 1000Genomes | |
| tmp_5_5688085_T_A | 172 | K>N | No | 1000Genomes | |
| ENSVATH06981108 | 181 | S>L | No | 1000Genomes | |
| ENSVATH03067472 | 184 | T>A | No | 1000Genomes | |
| tmp_5_5688044_A_G | 186 | L>S | No | 1000Genomes | |
| ENSVATH06981107 | 191 | S>A | No | 1000Genomes | |
| tmp_5_5688015_G_A | 196 | P>S | No | 1000Genomes | |
| tmp_5_5688000_CCACCTCCGT_ACACCTCCGT,TCACCTCCGT,C | 201 | A>S | No | 1000Genomes | |
| tmp_5_5688000_CCACCTCCGT_ACACCTCCGT,TCACCTCCGT,C | 201 | A>T | No | 1000Genomes | |
| ENSVATH00627030 | 230 | E>V | No | 1000Genomes | |
| ENSVATH00627029 | 242 | R>S | No | 1000Genomes | |
| ENSVATH00627028 | 248 | K>R | No | 1000Genomes | |
| ENSVATH00627025 | 261 | K>E | No | 1000Genomes | |
| ENSVATH00627024 | 261 | K>N | No | 1000Genomes | |
| ENSVATH03067465 | 266 | E>K | No | 1000Genomes | |
| ENSVATH00627023 | 274 | T>R | No | 1000Genomes | |
| tmp_5_5687340_T_G | 278 | E>D | No | 1000Genomes | |
| tmp_5_5687323_G_C | 284 | T>R | No | 1000Genomes | |
| ENSVATH06981096 | 292 | E>K | No | 1000Genomes | |
| ENSVATH03067464 | 298 | L>M | No | 1000Genomes | |
| ENSVATH00627022 | 310 | I>V | No | 1000Genomes | |
| tmp_5_5687203_A_C | 324 | F>C | No | 1000Genomes |
No associated diseases with Q9FFI2
No regional properties for Q9FFI2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q9FFI2 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Atg12-Atg5-Atg16 complex | A protein complex required for the expansion of the autophagosomal membrane. In budding yeast, this complex consists of Atg12p, Atg5p and Atg16p. |
| phagophore assembly site membrane | A cellular membrane associated with the phagophore assembly site. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagosome assembly | The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. |
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| autophagy of mitochondrion | The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions. |
| autophagy of nucleus | A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded. |
| C-terminal protein lipidation | The covalent attachment of a lipid group to the carboxy-terminus of a protein. |
| cellular response to nitrogen starvation | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen. |
| defense response to fungus | Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. |
| leaf senescence | The last stage of leaf development during which programmed degradation of macromolecules and nutrient recycling take place. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| response to starvation | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12380 | ATG5 | Autophagy protein 5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3MQ24 | ATG5 | Autophagy protein 5 | Bos taurus (Bovine) | PR |
| Q9H1Y0 | ATG5 | Autophagy protein 5 | Homo sapiens (Human) | PR |
| Q99J83 | Atg5 | Autophagy protein 5 | Mus musculus (Mouse) | PR |
| Q3MQ04 | ATG5 | Autophagy protein 5 | Sus scrofa (Pig) | PR |
| Q3MQ06 | Atg5 | Autophagy protein 5 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAKEAVKYVW | EGAIPLQIHL | HKSDVASHPA | PPPALVLAPR | IGYLPLLIPL | IKPYFKDSLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PGEDSIWFDY | KGFPLKWYIP | TGVLFDLLCA | EPERPWNLTI | HFRGYPCNIL | IPCEGEDSVK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WNFVNSLKEA | QYIINGNCKN | VMNMSQSDQE | DLWTSVMNGD | LDAYTRLSPK | LKMGTVEDEF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRKTSLSSPQ | SQQVVPETEV | AGQVKTARIP | VRLYVRSLNK | DFENLEDVPE | IDTWDDISYL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NRPVEFLKEE | GKCFTLRDAI | KSLLPEFMGD | RAQTSGEERS | IDDTEEADGS | REMGEIKLVR |
| 310 | 320 | 330 | |||
| IQGIEMKLEI | PFSWVVNNLM | NPEFYLHISV | LVKAPQR |